{"id":"etomidoline","rwe":[{"pmid":"33333074","year":"2021","title":"Characterization of human pregnane X receptor activators identified from a screening of the Tox21 compound library.","finding":"","journal":"Biochemical pharmacology","studyType":"Clinical Study"},{"pmid":"6620119","year":"1983","title":"Comparison of effects of smooth muscle relaxing drugs in intestinal smooth muscle of guinea pig.","finding":"","journal":"Journal of pharmacobio-dynamics","studyType":"Clinical Study"},{"pmid":"6273622","year":"1981","title":"Smooth muscle relaxing drugs and guinea pig ileum.","finding":"","journal":"Japanese journal of pharmacology","studyType":"Clinical Study"},{"pmid":"722958","year":"1978","title":"[Characteristic effect of etomidoline on contractile activity in the gastrointestinal tract in conscious dogs (author's transl)].","finding":"","journal":"Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology","studyType":"Clinical Study"},{"pmid":"1005295","year":"1976","title":"[Endoscopic evaluation of the etomidoline effect on gastric motility].","finding":"","journal":"La Prensa medica mexicana","studyType":"Clinical Study"}],"tags":[{"label":"etomidoline","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"smedolin","offLabel":[],"synonyms":["etomidolin","etomidoline","amidoline","smedolin"],"timeline":[],"approvals":[],"brandName":"Smedolin","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"etomidoline","explanation":"Imagine your body's cells are like locks, and Smedolin is a key that fits into those locks. When it binds to the locks, it sends a signal that can affect how your body works. This can help to treat certain conditions, but more research is needed to understand exactly how it works and what effects it has on the body.","oneSentence":"Smedolin works by interacting with specific receptors in the body to produce its effects.","technicalDetail":"Smedolin is a small molecule that binds to specific receptors, likely G-protein coupled receptors, to produce its effects. The exact receptor and signaling pathway involved are unknown, but it is believed to work through a complex series of molecular interactions."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3214","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ETOMIDOLINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:10:18.206523","biosimilars":[],"competitors":[],"genericName":"etomidoline","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"006005","UNII":"WFS7G78GYJ","CHEBI":"CHEBI:31584","INN_ID":"3353","RXNORM":"17684","UMLSCUI":"C0051591","ChEMBL_ID":"CHEMBL2106603","KEGG_DRUG":"D01359","PUBCHEM_CID":"3309","MESH_SUPPLEMENTAL_RECORD_UI":"C002545"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":5,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2021 Feb","pmid":"33333074","title":"Characterization of human pregnane X receptor activators identified from a screening of the Tox21 compound library.","journal":"Biochemical pharmacology"},{"date":"1983 May","pmid":"6620119","title":"Comparison of effects of smooth muscle relaxing drugs in intestinal smooth muscle of guinea pig.","journal":"Journal of pharmacobio-dynamics"},{"date":"1981 Apr","pmid":"6273622","title":"Smooth muscle relaxing drugs and guinea pig ileum.","journal":"Japanese journal of pharmacology"},{"date":"1978 Aug","pmid":"722958","title":"[Characteristic effect of etomidoline on contractile activity in the gastrointestinal tract in conscious dogs (author's transl)].","journal":"Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology"},{"date":"1976 Sep-Oct","pmid":"1005295","title":"[Endoscopic evaluation of the etomidoline effect on gastric motility].","journal":"La Prensa medica mexicana"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Smedolin, also known as etomidoline, is a small molecule drug in the etomidoline class. Its exact target and mechanism of action are unknown, but it is believed to work by interacting with specific receptors in the body. Smedolin's commercial status and approved indications are unclear, and it is not known whether it is patented or available as a generic medication. Further research is needed to fully understand its effects and potential uses. As a result, key safety considerations and pharmacokinetic properties, such as half-life and bioavailability, are also unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}