{"id":"etohexadiol","rwe":[],"tags":[{"label":"etohexadiol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"P03BX06","category":"atc"},{"label":"Active","category":"status"},{"label":"Insect repellent","category":"indication"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"ethohexadiol","offLabel":[],"synonyms":["etohexadiol","ethohexadiol","octylene glycol"],"timeline":[],"approvals":[],"brandName":"Ethohexadiol","ecosystem":[{"indication":"Insect repellent","otherDrugs":[{"name":"diethyltoluamide","slug":"diethyltoluamide","company":""}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"etohexadiol","explanation":"Think of it like a key that doesn't fit the lock. Etohexadiol blocks the key (human scent) from fitting into the lock (insect's sensory system), making it harder for insects to find and bite humans.","oneSentence":"Etohexadiol works by disrupting the insect's ability to detect and respond to human scent.","technicalDetail":"Etohexadiol is a small molecule that likely acts as a competitive inhibitor of the insect's olfactory receptors, preventing the binding of human scent molecules and thereby disrupting the insect's ability to detect and respond to human presence."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Etohexadiol","title":"Etohexadiol","extract":"Etohexadiol is an ectoparasiticide. It was known as the insect repellent \"6-12\" (Six-twelve), or Rutgers 612. Its use in the U.S. was halted in 1991 after it was shown to cause developmental defects in animals."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4774","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=etohexadiol","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Etohexadiol","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T11:10:12.136778","biosimilars":[],"competitors":[{"drugName":"diethyltoluamide","drugSlug":"diethyltoluamide","fdaApproval":"","relationship":"same-class"}],"genericName":"etohexadiol","indications":{"approved":[{"name":"Insect repellent","source":"DrugCentral","snomedId":75627006,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"diethyltoluamide","brandName":"diethyltoluamide","genericName":"diethyltoluamide","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"003002","UNII":"M9JGK7U88V","CHEBI":"CHEBI:34273","RXNORM":"1362891","UMLSCUI":"C0059726","ChEMBL_ID":"CHEMBL1451179","DRUGBANK_ID":"DB13826","PUBCHEM_CID":"7211","MESH_SUPPLEMENTAL_RECORD_UI":"C004917"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"P03BX06","allCodes":["P03BX06"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Etohexadiol is a small molecule etohexadiol drug used as an insect repellent. Its exact target is unknown, but it is believed to work by disrupting the insect's ability to detect and respond to human scent. Etohexadiol is currently used in commercial products, but its commercial status is unclear. It is not approved for human therapeutic use, but rather for use as an insect repellent. Further research is needed to fully understand its safety and efficacy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}