{"id":"etofylline-nicotinate","rwe":[],"tags":[{"label":"etofylline nicotinate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C04AD04","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Asthmatic Agents","category":"pharmacology"},{"label":"Bronchodilator Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Respiratory System Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"hesotanol","offLabel":[],"synonyms":["etofylline nicotinate","ethophylline nicotinate","hesotanol"],"timeline":[],"approvals":[],"brandName":"Hesotanol","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"etofylline nicotinate","explanation":"Imagine your blood vessels as roads that oxygen and nutrients need to travel down to reach your cells. Hesotanol is like a road crew that helps clear the way, making it easier for these essential supplies to get where they need to go. This can be especially helpful for people with conditions that affect blood flow or oxygen delivery.","oneSentence":"Hesotanol is thought to work by increasing blood flow and improving oxygen delivery to tissues.","technicalDetail":"Etofylline nicotinate is believed to exert its effects through a combination of vasodilation and increased erythrocyte flexibility, although the exact molecular mechanisms involved are not well-characterized."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Etofylline_nicotinate","title":"Etofylline nicotinate","extract":"Etofylline nicotinate is a vasodilator."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3212","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=etofylline%20nicotinate","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=etofylline nicotinate","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Etofylline_nicotinate","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T11:10:04.358844","biosimilars":[],"competitors":[{"drugName":"pentoxifylline","drugSlug":"pentoxifylline","fdaApproval":"1984-08-30","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"etofylline nicotinate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"pentoxifylline","brandName":"pentoxifylline","genericName":"pentoxifylline","approvalYear":"1984","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT05879406","phase":"NA","title":"A Study to Evaluate the Efficacy and Safety of Clear Skin Formula on Mitigating Mild to Moderate Non-cystic Acne","status":"COMPLETED","sponsor":"Ablon Skin Institute Research Center","startDate":"2023-05-31","conditions":["Non-Cystic Acne"],"enrollment":40,"completionDate":"2024-01-23"},{"nctId":"NCT06522412","phase":"NA","title":"The Effects of Jing-Si Herbal Tea Liquid Packets and Jing-Si Herbal Tang Heng Power Drink","status":"ACTIVE_NOT_RECRUITING","sponsor":"Buddhist Tzu Chi General Hospital","startDate":"2024-05-01","conditions":["Inflammatory Marker","Gut Microbiome","Trimethylamine N-oxide","HbA1c","Atherosclerosis"],"enrollment":200,"completionDate":"2026-12"},{"nctId":"NCT01749371","phase":"PHASE2,PHASE3","title":"Vitamin E Supplementation in Burned Patients","status":"COMPLETED","sponsor":"The University of Texas Medical Branch, Galveston","startDate":"2013-02","conditions":["Burn"],"enrollment":31,"completionDate":"2017-09"},{"nctId":"NCT03648333","phase":"PHASE1","title":"Clinical Trial to Assess the Pharmacokinetic Characteristics of Lodivixx Tab. 5/160mg in Healthy Male Subjects (N=27)","status":"COMPLETED","sponsor":"Hanlim Pharm. 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It is a vasodilator, a type of medication that helps to widen blood vessels.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}