{"id":"etofylline-clofibrate","rwe":[{"pmid":"41210757","year":"2025","title":"Targeting Ubiquitin-Specific Protease 7 (USP7): A Pharmacophore-Guided Drug Repurposing and Physics-Based Molecular Simulation Study.","finding":"","journal":"ACS omega","studyType":"Clinical Study"},{"pmid":"37253501","year":"2023","title":"Adverse drug reactions of non-statin antihyperlipidaemic drugs in China from 1989 to 2019: a national database analysis.","finding":"","journal":"BMJ open","studyType":"Clinical Study"},{"pmid":"8578698","year":"1995","title":"[Etofylline clofibrate in the treatment of diabetic dyslipidemia: results of a 6-month period of therapy].","finding":"","journal":"Vnitrni lekarstvi","studyType":"Clinical Study"},{"pmid":"2060543","year":"1991","title":"Comparative studies on the influence of different fibrates on serum lipoproteins in endogenous hyperlipoproteinaemia.","finding":"","journal":"European journal of clinical pharmacology","studyType":"Clinical Study"},{"pmid":"2726692","year":"1989","title":"Teratological study of the hypolipidaemic drugs etofylline clofibrate (VULM) and fenofibrate in Swiss mice.","finding":"","journal":"Pharmacology & toxicology","studyType":"Clinical Study"}],"tags":[{"label":"etofylline clofibrate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Anti-Asthmatic Agents","category":"pharmacology"},{"label":"Anticholesteremic Agents","category":"pharmacology"},{"label":"Antimetabolites","category":"pharmacology"},{"label":"Antioxidants","category":"pharmacology"},{"label":"Bronchodilator Agents","category":"pharmacology"},{"label":"Hypolipidemic Agents","category":"pharmacology"},{"label":"Lipid Regulating Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Protective Agents","category":"pharmacology"},{"label":"Radiation-Sensitizing Agents","category":"pharmacology"},{"label":"Respiratory System Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"theofibrate","offLabel":[],"synonyms":["etofylline clofibrate","ethophylline clofibrate","etophylline clofibrate","theofibrate"],"timeline":[],"approvals":[],"brandName":"Theofibrate","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"etofylline clofibrate","explanation":"Think of adenosine like a messenger in your body that helps regulate things like heart rate and blood pressure. When adenosine is released, it sends signals to different parts of the body to slow down or speed up certain processes. By blocking the reuptake of adenosine, theofibrate allows these signals to stay active for longer, which can help improve blood flow and lower blood pressure.","oneSentence":"Theofibrate is believed to work by inhibiting the reuptake of adenosine, a molecule involved in various physiological processes.","technicalDetail":"Theofibrate is a dual-acting compound that inhibits the reuptake of adenosine through the inhibition of adenosine transporters, such as ENT1, and also acts as a fibric acid derivative, which can modulate lipid metabolism and inflammation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1108","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=etofylline clofibrate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T13:43:47.221582","biosimilars":[],"competitors":[],"genericName":"etofylline clofibrate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005937","UNII":"14UH1JQP6L","CHEBI":"CHEBI:135681","INN_ID":"4271","RXNORM":"236713","UMLSCUI":"C0059870","ChEMBL_ID":"CHEMBL1318939","KEGG_DRUG":"D06102","PUBCHEM_CID":"41109","SNOMEDCT_US":"712689006","MESH_DESCRIPTOR_UI":"D002995","MESH_SUPPLEMENTAL_RECORD_UI":"C028764"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":20,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Nov 4","pmid":"41210757","title":"Targeting Ubiquitin-Specific Protease 7 (USP7): A Pharmacophore-Guided Drug Repurposing and Physics-Based Molecular Simulation Study.","journal":"ACS omega"},{"date":"2023 May 30","pmid":"37253501","title":"Adverse drug reactions of non-statin antihyperlipidaemic drugs in China from 1989 to 2019: a national database analysis.","journal":"BMJ open"},{"date":"1995 Oct","pmid":"8578698","title":"[Etofylline clofibrate in the treatment of diabetic dyslipidemia: results of a 6-month period of therapy].","journal":"Vnitrni lekarstvi"},{"date":"1991","pmid":"2060543","title":"Comparative studies on the influence of different fibrates on serum lipoproteins in endogenous hyperlipoproteinaemia.","journal":"European journal of clinical pharmacology"},{"date":"1989 Mar","pmid":"2726692","title":"Teratological study of the hypolipidaemic drugs etofylline clofibrate (VULM) and fenofibrate in Swiss mice.","journal":"Pharmacology & toxicology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Theofibrate, also known as etofylline clofibrate, is a small molecule drug in the etofylline clofibrate class. Unfortunately, there is limited information available on this compound, including its target, FDA approval status, and approved indications. As a result, it is difficult to provide a comprehensive summary of its use and safety profile. Further research is needed to determine the commercial status and key safety considerations of theofibrate. Without more information, it is challenging to provide a clear understanding of its mechanism of action and potential benefits.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}