{"id":"etofylline","rwe":[{"pmid":"41210757","year":"2025","title":"Targeting Ubiquitin-Specific Protease 7 (USP7): A Pharmacophore-Guided Drug Repurposing and Physics-Based Molecular Simulation Study.","finding":"","journal":"ACS omega","studyType":"Clinical Study"},{"pmid":"38893328","year":"2024","title":"Assessment of Bitterness in Non-Charged Pharmaceuticals with a Taste Sensor: A Study on Substances with Xanthine Scaffold and Allopurinol.","finding":"","journal":"Molecules (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"37253501","year":"2023","title":"Adverse drug reactions of non-statin antihyperlipidaemic drugs in China from 1989 to 2019: a national database analysis.","finding":"","journal":"BMJ open","studyType":"Clinical Study"},{"pmid":"32987078","year":"2020","title":"Mannose-anchored N,N,N-trimethyl chitosan nanoparticles for pulmonary administration of etofylline.","finding":"","journal":"International journal of biological macromolecules","studyType":"Clinical Study"},{"pmid":"31181483","year":"2019","title":"Development and validation of a UPLC-MS/MS method for quantification of doxofylline and its metabolites in human plasma.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"}],"tags":[{"label":"etofylline","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Adenosine receptor A2b","category":"target"},{"label":"ADORA2B","category":"gene"},{"label":"Active","category":"status"},{"label":"Anti-Asthmatic Agents","category":"pharmacology"},{"label":"Bronchodilator Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Respiratory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"cordalin","offLabel":[],"synonyms":["aethophyllinum","ascorphylline","cordalin","dilaphyllin","etophyllin","etophylline","hydroxyethyltheophylline","oxphylline","oxyethophylline","oxyethyltheophylline","oxyphyllin","oxyphylline","oxytheonyl","etofylline"],"timeline":[],"approvals":[],"brandName":"Cordalin","ecosystem":[],"mechanism":{"target":"Adenosine receptor A2b","targets":[{"gene":"ADORA2B","source":"DrugCentral","target":"Adenosine receptor A2b","protein":"Adenosine receptor A2b"}],"modality":"Small Molecule","drugClass":"etofylline","explanation":"Think of adenosine like a messenger in your body that helps regulate various functions, such as heart rate and blood pressure. Etofylline helps control how strongly this messenger is received by its receptors, which can have different effects depending on the situation.","oneSentence":"Etofylline works by binding to the adenosine receptor A2b, which affects the activity of adenosine.","technicalDetail":"Etofylline acts as a non-selective adenosine receptor antagonist, with a high affinity for the A2b subtype, which is involved in the regulation of inflammatory responses and vascular tone."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1107","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ETOFYLLINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:09:58.867575","biosimilars":[],"competitors":[{"drugName":"adenosine","drugSlug":"adenosine","fdaApproval":"1989-10-30","genericCount":15,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"caffeine","drugSlug":"caffeine","fdaApproval":"1948-11-26","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"choline theophyllinate","drugSlug":"choline-theophyllinate","fdaApproval":"1981-11-05","relationship":"same-target"},{"drugName":"istradefylline","drugSlug":"istradefylline","fdaApproval":"2019-08-27","patentExpiry":"Sep 5, 2027","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"pentoxifylline","drugSlug":"pentoxifylline","fdaApproval":"1984-08-30","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"regadenoson","drugSlug":"regadenoson","fdaApproval":"2008-04-10","patentExpiry":"Feb 2, 2027","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"theophylline","drugSlug":"theophylline","fdaApproval":"1940-04-19","genericCount":53,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"etofylline","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"adenosine","brandName":"adenosine","genericName":"adenosine","approvalYear":"1989","relationship":"same-target"},{"drugId":"caffeine","brandName":"caffeine","genericName":"caffeine","approvalYear":"1948","relationship":"same-target"},{"drugId":"choline-theophyllinate","brandName":"choline theophyllinate","genericName":"choline theophyllinate","approvalYear":"1981","relationship":"same-target"},{"drugId":"istradefylline","brandName":"istradefylline","genericName":"istradefylline","approvalYear":"2019","relationship":"same-target"},{"drugId":"pentoxifylline","brandName":"pentoxifylline","genericName":"pentoxifylline","approvalYear":"1984","relationship":"same-target"},{"drugId":"regadenoson","brandName":"regadenoson","genericName":"regadenoson","approvalYear":"2008","relationship":"same-target"},{"drugId":"theophylline","brandName":"theophylline","genericName":"theophylline","approvalYear":"1940","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"005937","UNII":"L164909TBI","CHEBI":"CHEBI:94764","INN_ID":"1667","RXNORM":"24611","UMLSCUI":"C0059871","ChEMBL_ID":"CHEMBL699","KEGG_DRUG":"D07933","PUBCHEM_CID":"1892","SNOMEDCT_US":"712689006","MESH_SUPPLEMENTAL_RECORD_UI":"C008749"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","bioavailability":"80%"},"publicationCount":40,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Nov 4","pmid":"41210757","title":"Targeting Ubiquitin-Specific Protease 7 (USP7): A Pharmacophore-Guided Drug Repurposing and Physics-Based Molecular Simulation Study.","journal":"ACS omega"},{"date":"2024 May 23","pmid":"38893328","title":"Assessment of Bitterness in Non-Charged Pharmaceuticals with a Taste Sensor: A Study on Substances with Xanthine Scaffold and Allopurinol.","journal":"Molecules (Basel, Switzerland)"},{"date":"2023 May 30","pmid":"37253501","title":"Adverse drug reactions of non-statin antihyperlipidaemic drugs in China from 1989 to 2019: a national database analysis.","journal":"BMJ open"},{"date":"2020 Dec 15","pmid":"32987078","title":"Mannose-anchored N,N,N-trimethyl chitosan nanoparticles for pulmonary administration of etofylline.","journal":"International journal of biological macromolecules"},{"date":"2019 Sep 10","pmid":"31181483","title":"Development and validation of a UPLC-MS/MS method for quantification of doxofylline and its metabolites in human plasma.","journal":"Journal of pharmaceutical and biomedical analysis"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cordalin is a small molecule with synonyms including Clofibrate Etofylline, and it is classified as a modality of small molecule.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}