{"id":"etofibrate","rwe":[{"pmid":"39504766","year":"2024","title":"Emerging contaminants as indicators of short-term environmental changes in an eutrophicated coastal lagoon.","finding":"","journal":"Marine pollution bulletin","studyType":"Clinical Study"},{"pmid":"23062606","year":"2012","title":"Biodegradation of clofibric acid and identification of its metabolites.","finding":"","journal":"Journal of hazardous materials","studyType":"Clinical Study"},{"pmid":"20873411","year":"2010","title":"Methods of chromatographic determination of medicines decreasing the level of cholesterol.","finding":"","journal":"Acta poloniae pharmaceutica","studyType":"Clinical Study"},{"pmid":"19644802","year":"2009","title":"[Efficacy and safety of etofibrate in patients with non-proliferative diabetic retinopathy].","finding":"","journal":"Klinische Monatsblatter fur Augenheilkunde","studyType":"Clinical Study"},{"pmid":"19330175","year":"2009","title":"Etofibrate enhances 123I-LDL-binding in human liver.","finding":"","journal":"Hellenic journal of nuclear medicine","studyType":"Clinical Study"}],"tags":[{"label":"etofibrate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C10AB09","category":"atc"},{"label":"Active","category":"status"},{"label":"Anticholesteremic Agents","category":"pharmacology"},{"label":"Antimetabolites","category":"pharmacology"},{"label":"Hypolipidemic Agents","category":"pharmacology"},{"label":"Lipid Regulating Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"tricerol","offLabel":[],"synonyms":["etofibrate hydrochloride","etofibrate HCl","etofibrate","ethofibrate","tricerol"],"timeline":[],"approvals":[],"brandName":"Tricerol","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"etofibrate","explanation":"Think of it like a traffic cop: ACAT is like a traffic cop that helps cholesterol get into the bloodstream. Tricerol blocks this traffic cop, making it harder for cholesterol to get into the bloodstream and reducing the risk of heart disease.","oneSentence":"Tricerol works by inhibiting the enzyme acyl-CoA:cholesterol acyltransferase (ACAT), which is involved in the formation of cholesterol esters.","technicalDetail":"Tricerol (Etofibrate) acts as a selective inhibitor of ACAT, specifically ACAT2, which is the primary isoform involved in the formation of cholesterol esters in the liver. This inhibition leads to a decrease in the formation of cholesterol esters and an increase in the clearance of triglycerides from the bloodstream."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1106","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ETOFIBRATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:23:03.717095","biosimilars":[],"competitors":[{"drugName":"clofibrate","drugSlug":"clofibrate","fdaApproval":"1967-02-08","genericCount":5,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"gemfibrozil","drugSlug":"gemfibrozil","fdaApproval":"1981-12-21","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"fenofibrate","drugSlug":"fenofibrate","fdaApproval":"1993-12-31","patentExpiry":"May 31, 2033","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"choline fenofibrate","drugSlug":"choline-fenofibrate","fdaApproval":"2008-12-15","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"etofibrate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"clofibrate","brandName":"clofibrate","genericName":"clofibrate","approvalYear":"1967","relationship":"same-class"},{"drugId":"gemfibrozil","brandName":"gemfibrozil","genericName":"gemfibrozil","approvalYear":"1981","relationship":"same-class"},{"drugId":"fenofibrate","brandName":"fenofibrate","genericName":"fenofibrate","approvalYear":"1993","relationship":"same-class"},{"drugId":"choline-fenofibrate","brandName":"choline fenofibrate","genericName":"choline fenofibrate","approvalYear":"2008","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"MMSL":"2275","NDDF":"001052","UNII":"23TF67G79M","CHEBI":"CHEBI:135535","VANDF":"4017661","INN_ID":"3616","RXNORM":"24609","UMLSCUI":"C0059869","ChEMBL_ID":"CHEMBL358150","KEGG_DRUG":"D07187","DRUGBANK_ID":"DB08983","PDB_CHEM_ID":" NIO","PUBCHEM_CID":"65777","SNOMEDCT_US":"273943001","MESH_DESCRIPTOR_UI":"D002995","MESH_SUPPLEMENTAL_RECORD_UI":"C009746"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":85,"therapeuticAreas":["Metabolic"],"atcClassification":{"source":"DrugCentral","atcCode":"C10AB09","allCodes":["C10AB09"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024 Dec","pmid":"39504766","title":"Emerging contaminants as indicators of short-term environmental changes in an eutrophicated coastal lagoon.","journal":"Marine pollution bulletin"},{"date":"2012 Nov 30","pmid":"23062606","title":"Biodegradation of clofibric acid and identification of its metabolites.","journal":"Journal of hazardous materials"},{"date":"2010 Sep-Oct","pmid":"20873411","title":"Methods of chromatographic determination of medicines decreasing the level of cholesterol.","journal":"Acta poloniae pharmaceutica"},{"date":"2009 Jul","pmid":"19644802","title":"[Efficacy and safety of etofibrate in patients with non-proliferative diabetic retinopathy].","journal":"Klinische Monatsblatter fur Augenheilkunde"},{"date":"2009 Jan-Apr","pmid":"19330175","title":"Etofibrate enhances 123I-LDL-binding in human liver.","journal":"Hellenic journal of nuclear medicine"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tricerol (Etofibrate) is a small molecule etofibrate, a type of fibric acid derivative. It is used to treat high cholesterol and triglyceride levels. However, there is limited information available on its commercial status, approved indications, and pharmacokinetic properties. Further research is needed to determine its efficacy and safety profile. As a result, it is not widely used or recognized in the pharmaceutical industry.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}