{"id":"etofenamate","rwe":[{"pmid":"41903515","year":"2026","title":"Prospective Multi-Centre Photopatch Test Study of Photoallergy to Sunscreens and NSAIDs in Europe.","finding":"","journal":"The British journal of dermatology","studyType":"Clinical Study"},{"pmid":"41159779","year":"2026","title":"Effective Treatment of Nicolau Syndrome Induced by Etofenamate Injection Using Hyperbaric Oxygen Therapy.","finding":"","journal":"Advances in skin & wound care","studyType":"Clinical Study"},{"pmid":"40855120","year":"2025","title":"Effect of etofenamate on midline closure defect in early chicken embryos: an experimental study.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"40676414","year":"2025","title":"A Randomized Placebo-Controlled Trial of the Efficacy and Tolerability of Etofenamate 70 mg Medicated Plaster for the Treatment of Pain in Acute Sprains, Strains or Bruises of the Soft Tissues Following Blunt Trauma.","finding":"","journal":"Pain and therapy","studyType":"Clinical Study"},{"pmid":"39275959","year":"2024","title":"Innovative UPLC technique for concurrent quantification of etofenamate and benzyl nicotinate in the presence of methylparaben and benzyl alcohol in their topical cream: Greens, white, and Six Sigma methodologies.","finding":"","journal":"Biomedical chromatography : BMC","studyType":"Clinical Study"}],"tags":[{"label":"etofenamate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"M02AA06","category":"atc"},{"label":"Active","category":"status"},{"label":"Osteoarthritis","category":"indication"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"etofen","offLabel":[],"synonyms":["flogoprofen","etofen","etofenamate","bayrogel","rheumon"],"timeline":[],"approvals":[],"brandName":"Etofen","ecosystem":[{"indication":"Osteoarthritis","otherDrugs":[{"name":"aceclofenac","slug":"aceclofenac","company":""},{"name":"acetylsalicylic acid","slug":"acetylsalicylic-acid","company":"Endo Pharms"},{"name":"celecoxib","slug":"celecoxib","company":"Gd Searle"},{"name":"choline magnesium trisalicylate","slug":"choline-magnesium-trisalicylate","company":""}],"globalPrevalence":655000000}],"mechanism":{"modality":"Small Molecule","drugClass":"etofenamate","explanation":"Imagine your body has a factory that produces chemicals called prostaglandins, which are like messengers that tell your brain that you're in pain. Etofenamate is like a key that locks the factory door, stopping the production of these pain-causing chemicals. This helps to reduce pain and inflammation in people with osteoarthritis.","oneSentence":"Etofenamate works by blocking the production of prostaglandins, which are chemicals that cause pain and inflammation.","technicalDetail":"Etofenamate is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits the enzyme cyclooxygenase (COX), which is responsible for the conversion of arachidonic acid to prostaglandins."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3211","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=ETOFENAMATE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ETOFENAMATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:09:52.634156","biosimilars":[],"competitors":[{"drugName":"phenylbutazone","drugSlug":"phenylbutazone","fdaApproval":"1980-01-10","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"oxyphenbutazone","drugSlug":"oxyphenbutazone","fdaApproval":"1960-12-21","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"piroxicam","drugSlug":"piroxicam","fdaApproval":"1982-04-06","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ketoprofen","drugSlug":"ketoprofen","fdaApproval":"1986-01-09","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"naproxen","drugSlug":"naproxen","fdaApproval":"1976-03-11","genericCount":31,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ibuprofen","drugSlug":"ibuprofen","fdaApproval":"1974-09-19","patentExpiry":"Sep 30, 2029","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"diclofenac","drugSlug":"diclofenac","fdaApproval":"1988-07-28","patentExpiry":"Apr 23, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"meclofenamic acid","drugSlug":"meclofenamic-acid","fdaApproval":"1980-06-25","relationship":"same-class"},{"drugName":"flurbiprofen","drugSlug":"flurbiprofen","fdaApproval":"1986-12-31","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"tolmetin","drugSlug":"tolmetin","fdaApproval":"1976-03-24","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"indomethacin","drugSlug":"indomethacin","fdaApproval":"1965-06-10","patentExpiry":"Apr 23, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"aceclofenac","drugSlug":"aceclofenac","fdaApproval":"","relationship":"same-class"}],"genericName":"etofenamate","indications":{"approved":[{"name":"Osteoarthritis","source":"DrugCentral","snomedId":396275006,"regulator":"FDA","usPrevalence":null,"globalPrevalence":655000000,"prevalenceMethod":"curated","prevalenceSource":"Arthritis Res Ther, 2023 (PMID:36991481)"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"phenylbutazone","brandName":"phenylbutazone","genericName":"phenylbutazone","approvalYear":"1980","relationship":"same-class"},{"drugId":"oxyphenbutazone","brandName":"oxyphenbutazone","genericName":"oxyphenbutazone","approvalYear":"1960","relationship":"same-class"},{"drugId":"piroxicam","brandName":"piroxicam","genericName":"piroxicam","approvalYear":"1982","relationship":"same-class"},{"drugId":"ketoprofen","brandName":"ketoprofen","genericName":"ketoprofen","approvalYear":"1986","relationship":"same-class"},{"drugId":"naproxen","brandName":"naproxen","genericName":"naproxen","approvalYear":"1976","relationship":"same-class"},{"drugId":"ibuprofen","brandName":"ibuprofen","genericName":"ibuprofen","approvalYear":"1974","relationship":"same-class"},{"drugId":"diclofenac","brandName":"diclofenac","genericName":"diclofenac","approvalYear":"1988","relationship":"same-class"},{"drugId":"meclofenamic-acid","brandName":"meclofenamic acid","genericName":"meclofenamic acid","approvalYear":"1980","relationship":"same-class"},{"drugId":"flurbiprofen","brandName":"flurbiprofen","genericName":"flurbiprofen","approvalYear":"1986","relationship":"same-class"},{"drugId":"tolmetin","brandName":"tolmetin","genericName":"tolmetin","approvalYear":"1976","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT06623929","phase":"","title":"Topical Treatments for Ankle Sprains","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ankara City Hospital Bilkent","startDate":"2024-01-01","conditions":["Ankle Sprain"],"enrollment":100,"completionDate":"2024-11-01"},{"nctId":"NCT00530387","phase":"NA","title":"Multi-Centre European Photopatch Test Study","status":"COMPLETED","sponsor":"NHS Tayside","startDate":"2008-07","conditions":["Dermatitis, Photocontact"],"enrollment":1000,"completionDate":"2011-07"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"004354","UNII":"KZF0XM66JC","CHEBI":"CHEBI:94731","INN_ID":"3359","RXNORM":"24608","UMLSCUI":"C0059868","ChEMBL_ID":"CHEMBL1451633","KEGG_DRUG":"D04102","DRUGBANK_ID":"DB08984","PUBCHEM_CID":"35375","SNOMEDCT_US":"712688003","MESH_SUPPLEMENTAL_RECORD_UI":"C015207"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":109,"therapeuticAreas":["Immunology"],"atcClassification":{"source":"DrugCentral","atcCode":"M02AA06","allCodes":["M02AA06"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 28","pmid":"41903515","title":"Prospective Multi-Centre Photopatch Test Study of Photoallergy to Sunscreens and NSAIDs in Europe.","journal":"The British journal of dermatology"},{"date":"2026 Jan-Feb 01","pmid":"41159779","title":"Effective Treatment of Nicolau Syndrome Induced by Etofenamate Injection Using Hyperbaric Oxygen Therapy.","journal":"Advances in skin & wound care"},{"date":"2025 Aug 25","pmid":"40855120","title":"Effect of etofenamate on midline closure defect in early chicken embryos: an experimental study.","journal":"Scientific reports"},{"date":"2025 Oct","pmid":"40676414","title":"A Randomized Placebo-Controlled Trial of the Efficacy and Tolerability of Etofenamate 70 mg Medicated Plaster for the Treatment of Pain in Acute Sprains, Strains or Bruises of the Soft Tissues Following Blunt Trauma.","journal":"Pain and therapy"},{"date":"2024 Nov","pmid":"39275959","title":"Innovative UPLC technique for concurrent quantification of etofenamate and benzyl nicotinate in the presence of methylparaben and benzyl alcohol in their topical cream: Greens, white, and Six Sigma methodologies.","journal":"Biomedical chromatography : BMC"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Etofenamate is a small molecule drug in the etofenamate class, used to treat osteoarthritis. Its exact target is unknown, but it is believed to work by inhibiting the production of prostaglandins, which are chemicals that cause pain and inflammation. Etofenamate is not currently listed as an off-patent medication, but its commercial status is unclear. As a result, its availability and pricing may vary. Further research is needed to fully understand its pharmacokinetics and safety profile.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}