{"id":"etodroxizine","rwe":[{"pmid":"37899967","year":"2023","title":"Drug repurposing by in silico prediction of cyclizine derivatives as antihyperlipemic agents.","finding":"","journal":"In silico pharmacology","studyType":"Clinical Study"},{"pmid":"2905131","year":"1988","title":"Interaction of two barbiturates and an antihistamine on body temperature and motor performance of mice.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"9296","year":"1975","title":"Effects of dixyrazine and methaqualone on the sleep pattern in normal man.","finding":"","journal":"European journal of clinical pharmacology","studyType":"Clinical Study"},{"pmid":"4899293","year":"1969","title":"A double-blind clinical trial of a new sleep-inducing combination of methaqualone and etodroxizine compared with nitrazepam and placebo.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"4899292","year":"1969","title":"Comparative clinical studies of a new somnifacient combination of methaqualone and etodroxizine versus glutethimide and placebo. Cross-over double-blind control test with sequential analysis.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"}],"tags":[{"label":"etodroxizine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"etodroxyzine","offLabel":[],"synonyms":["etodroxizine maleate","etodroxizine","etodroxyzine","hydrochlorbenzethylamine"],"timeline":[],"approvals":[],"brandName":"Etodroxyzine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"etodroxizine","explanation":"Imagine your body's cells are like locks, and etodroxizine is a key that fits into one of those locks. When it binds to the lock, it can either turn it on or off, depending on the type of lock. However, the specific lock that etodroxizine binds to is currently unknown.","oneSentence":"Etodroxizine is thought to work by interacting with a specific molecular target, but its exact mechanism is currently unknown.","technicalDetail":"Etodroxizine is a small molecule that likely interacts with a specific protein or receptor, but the exact nature of this interaction is unclear and requires further research to determine."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Etodroxizine","title":"Etodroxizine","extract":"Etodroxizine is a first-generation antihistamine of the diphenylmethylpiperazine group which is used as a sedative/hypnotic drug in Europe and South Africa."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1104","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ETODROXIZINE","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Etodroxizine","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T11:09:47.154085","biosimilars":[],"competitors":[],"genericName":"etodroxizine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"CI1S3XAK7O","CHEBI":"CHEBI:135677","INN_ID":"2374","UMLSCUI":"C0059866","ChEMBL_ID":"CHEMBL2104263","PUBCHEM_CID":"63345","SECONDARY_CAS_RN":"53859-10-2","MESH_SUPPLEMENTAL_RECORD_UI":"C001197"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":6,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2023","pmid":"37899967","title":"Drug repurposing by in silico prediction of cyclizine derivatives as antihyperlipemic agents.","journal":"In silico pharmacology"},{"date":"1988 Jul","pmid":"2905131","title":"Interaction of two barbiturates and an antihistamine on body temperature and motor performance of mice.","journal":"Arzneimittel-Forschung"},{"date":"1975 Apr 4","pmid":"9296","title":"Effects of dixyrazine and methaqualone on the sleep pattern in normal man.","journal":"European journal of clinical pharmacology"},{"date":"1969 Sep","pmid":"4899293","title":"A double-blind clinical trial of a new sleep-inducing combination of methaqualone and etodroxizine compared with nitrazepam and placebo.","journal":"Arzneimittel-Forschung"},{"date":"1969 Sep","pmid":"4899292","title":"Comparative clinical studies of a new somnifacient combination of methaqualone and etodroxizine versus glutethimide and placebo. Cross-over double-blind control test with sequential analysis.","journal":"Arzneimittel-Forschung"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Etodroxizine is a small molecule drug in the etodroxizine class, but its target and mechanism of action are unknown. Its commercial status and approved indications are also unclear. As a result, there is limited information available on its safety profile and pharmacokinetic properties. Further research is needed to fully understand this compound. Its development history is also unclear.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}