{"id":"etizolam","rwe":[{"pmid":"41863317","year":"2026","title":"Determination of Specific Absorbance (A¦) for Four Designer Benzodiazepines.","finding":"","journal":"Journal of analytical toxicology","studyType":"Clinical Study"},{"pmid":"41719725","year":"2026","title":"Changing characteristics in the 2020s of fatal 'novel' benzodiazepine toxicity cases in Australia.","finding":"","journal":"Drug and alcohol dependence","studyType":"Clinical Study"},{"pmid":"41570696","year":"2026","title":"Teneurin-4 in the nucleus accumbens modulates affective-like behaviors with potential effects on astrocytes in male mice.","finding":"","journal":"Biochemical and biophysical research communications","studyType":"Clinical Study"},{"pmid":"41360139","year":"2025","title":"Comparing Etizolam and Music Distraction on Inferior Alveolar Nerve Block Success in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial.","finding":"","journal":"Anesthesia 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Agents","category":"pharmacology"}],"phase":"marketed","safety":{"safetySignals":[{"llr":806.121,"date":"","count":523,"signal":"Toxicity to various agents","source":"DrugCentral FAERS","actionTaken":"Reported 523 times (LLR=806)"},{"llr":366.659,"date":"","count":220,"signal":"Drug abuse","source":"DrugCentral FAERS","actionTaken":"Reported 220 times (LLR=367)"},{"llr":239.913,"date":"","count":97,"signal":"Respiratory depression","source":"DrugCentral FAERS","actionTaken":"Reported 97 times (LLR=240)"},{"llr":135.522,"date":"","count":90,"signal":"Hepatic function abnormal","source":"DrugCentral FAERS","actionTaken":"Reported 90 times (LLR=136)"},{"llr":116.154,"date":"","count":89,"signal":"Pulmonary oedema","source":"DrugCentral FAERS","actionTaken":"Reported 89 times (LLR=116)"},{"llr":87.32,"date":"","count":16,"signal":"Counterfeit product administered","source":"DrugCentral FAERS","actionTaken":"Reported 16 times (LLR=87)"},{"llr":82.607,"date":"","count":56,"signal":"Altered state of consciousness","source":"DrugCentral FAERS","actionTaken":"Reported 56 times (LLR=83)"},{"llr":79.628,"date":"","count":27,"signal":"Alcohol interaction","source":"DrugCentral FAERS","actionTaken":"Reported 27 times (LLR=80)"},{"llr":79.57,"date":"","count":80,"signal":"Interstitial lung disease","source":"DrugCentral FAERS","actionTaken":"Reported 80 times (LLR=80)"},{"llr":78.391,"date":"","count":16,"signal":"Fatigue","source":"DrugCentral FAERS","actionTaken":"Reported 16 times (LLR=78)"},{"llr":73.098,"date":"","count":149,"signal":"Drug interaction","source":"DrugCentral FAERS","actionTaken":"Reported 149 times (LLR=73)"},{"llr":67.512,"date":"","count":71,"signal":"Intentional overdose","source":"DrugCentral FAERS","actionTaken":"Reported 71 times (LLR=68)"},{"llr":65.497,"date":"","count":35,"signal":"Spinal compression fracture","source":"DrugCentral FAERS","actionTaken":"Reported 35 times (LLR=65)"},{"llr":65.042,"date":"","count":37,"signal":"Drug 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This enhances the receptor's sensitivity to GABA, leading to increased chloride ion influx and hyperpolarization of the neuron, resulting in a calming effect on the brain."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Depas_Amphikypellon","title":"Depas Amphikypellon","extract":"Depas Amphikypellon is a distinctive Bronze Age drinking cup. Typically it is a tall, narrow beaker with a round base and two large handles opposite each other. These vessels are widely distributed from the Greek mainland to northern Syria and as far as Euphrates. They are especially common in the extensive areas of Anatolia."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1102","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=ETIZOLAM","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ETIZOLAM","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Depas_Amphikypellon","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T11:09:41.363087","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:02:29.761177+00:00","fieldsConflicting":2,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"diazepam","drugSlug":"diazepam","fdaApproval":"1963-11-15","patentExpiry":"Oct 16, 2032","patentStatus":"Patent 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