{"id":"ethylnorepinephrine","rwe":[{"pmid":"4613","year":"1976","title":"Dissociation constants and relative efficacies of agonists acting on alpha adrenergic receptors in rabbit aorta.","finding":"","journal":"The Journal of pharmacology and experimental therapeutics","studyType":"Clinical Study"},{"pmid":"13533786","year":"1958","title":"Ethylnorepinephrine; a unique bronchodilator.","finding":"","journal":"American practitioner and digest of treatment","studyType":"Clinical Study"},{"pmid":"13500349","year":"1958","title":"A case of calcified ventricular aneurysm with progressive heart block; observations on the effect of ethylnorepinephrine.","finding":"","journal":"Cardiologia","studyType":"Clinical Study"},{"pmid":"15429016","year":"1950","title":"The pharmacologic action of some analogs of 1-(3,4-dihydroxyphenyl)-2-amino-1-butanol (ethylnorepinephrine).","finding":"","journal":"The Journal of pharmacology and experimental therapeutics","studyType":"Clinical Study"},{"pmid":"18917406","year":"1948","title":"Spirometric evaluation of ethyl-nor-epinephrine in bronchial asthma.","finding":"","journal":"The Journal of allergy","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Acute exacerbation of asthma","category":"indication"},{"label":"Asthma","category":"indication"},{"label":"Asthma management","category":"indication"},{"label":"Bronchiectasis","category":"indication"},{"label":"Bronchitis","category":"indication"},{"label":"Pulmonary emphysema","category":"indication"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"butanefrine","offLabel":[],"synonyms":["ethylnorepinephrine","ethylnorepinephrine hydrochloride","ethylarterenol","(+/-)-Ethylnorepinephrine","butanefrine","butanephrin","butanephrine","ethylnoradrenaline","ethylnorsprarenin","ethylnorsuprarenin","ethylnoradrenaline hydrochloride","ethylnorepinephrine HCl","ethylnoradrenaline HCl"],"timeline":[],"approvals":[],"brandName":"Butanefrine","ecosystem":[{"indication":"Acute exacerbation of asthma","otherDrugs":[{"name":"bitolterol","slug":"bitolterol","company":"Sanofi Aventis Us"},{"name":"epinephrine","slug":"epinephrine","company":""},{"name":"levosalbutamol","slug":"levosalbutamol","company":"Oak Pharms Inc"},{"name":"norepinephrine","slug":"norepinephrine","company":"Hospira"}],"globalPrevalence":262000000},{"indication":"Asthma","otherDrugs":[{"name":"beclometasone dipropionate","slug":"beclometasone-dipropionate","company":""},{"name":"betamethasone","slug":"betamethasone","company":""},{"name":"betamethasone acetate","slug":"betamethasone-acetate","company":""},{"name":"bitolterol","slug":"bitolterol","company":"Sanofi Aventis Us"}],"globalPrevalence":262000000},{"indication":"Asthma management","otherDrugs":[{"name":"beclometasone dipropionate","slug":"beclometasone-dipropionate","company":""},{"name":"bitolterol","slug":"bitolterol","company":"Sanofi Aventis Us"},{"name":"budesonide","slug":"budesonide","company":""},{"name":"ciclesonide","slug":"ciclesonide","company":"Takeda Gmbh"}],"globalPrevalence":262000000},{"indication":"Bronchiectasis","otherDrugs":[{"name":"acetylcysteine","slug":"acetylcysteine","company":"Apothecon"},{"name":"bitolterol","slug":"bitolterol","company":"Sanofi Aventis Us"},{"name":"cysteine","slug":"cysteine","company":"Hospira"},{"name":"epinephrine","slug":"epinephrine","company":""}],"globalPrevalence":null},{"indication":"Bronchitis","otherDrugs":[{"name":"acetylcysteine","slug":"acetylcysteine","company":"Apothecon"},{"name":"amphotericin B","slug":"amphotericin-b","company":"Apothecon"},{"name":"bitolterol","slug":"bitolterol","company":"Sanofi Aventis Us"},{"name":"cefixime","slug":"cefixime","company":""}],"globalPrevalence":null},{"indication":"Pulmonary emphysema","otherDrugs":[{"name":"arformoterol","slug":"arformoterol","company":"Sunovion"},{"name":"bitolterol","slug":"bitolterol","company":"Sanofi Aventis Us"},{"name":"diprophylline","slug":"diprophylline","company":""},{"name":"epinephrine","slug":"epinephrine","company":""}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your airways are like a narrow road that needs to be widened to let air pass through. Butanefrine helps to constrict the surrounding blood vessels, which reduces blood flow to the area and allows the airway to open up, making it easier to breathe.","oneSentence":"Butanefrine works by stimulating the body's natural responses to constrict blood vessels and increase airway resistance.","technicalDetail":"Butanefrine is a sympathomimetic agent that acts on the alpha-adrenergic receptors to produce vasoconstriction and bronchoconstriction, leading to increased airway resistance and improved respiratory function."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Ethylnorepinephrine","title":"Ethylnorepinephrine","extract":"Ethylnorepinephrine, sold under the brand names Etanor, Bronkephrine, and Butanefrine, is a sympathomimetic and bronchodilator medication related to norepinephrine. It activates both α and β adrenergic receptors."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3208","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ethylnorepinephrine","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Ethylnorepinephrine","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T11:08:56.994991","biosimilars":[],"competitors":[],"genericName":"ethylnorepinephrine","indications":{"approved":[{"name":"Acute exacerbation of asthma","source":"DrugCentral","snomedId":708038006,"regulator":"FDA","usPrevalence":25000000,"globalPrevalence":262000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"},{"name":"Asthma","source":"DrugCentral","snomedId":195967001,"regulator":"FDA","usPrevalence":25000000,"globalPrevalence":262000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"},{"name":"Asthma management","source":"DrugCentral","snomedId":406162001,"regulator":"FDA","usPrevalence":25000000,"globalPrevalence":262000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"},{"name":"Bronchiectasis","source":"DrugCentral","snomedId":12295008,"regulator":"FDA"},{"name":"Bronchitis","source":"DrugCentral","snomedId":32398004,"regulator":"FDA"},{"name":"Pulmonary emphysema","source":"DrugCentral","snomedId":87433001,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000147842","NDDF":"001782","UNII":"M6AY4VCZ0A","VUID":"4019751","CHEBI":"CHEBI:134857","VANDF":"4018238","RXNORM":"156240","UMLSCUI":"C0602107","ChEMBL_ID":"CHEMBL31159","PUBCHEM_CID":"18538","SNOMEDCT_US":"108608005","SECONDARY_CAS_RN":"3198-07-0","MESH_SUPPLEMENTAL_RECORD_UI":"C004887"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":7,"therapeuticAreas":["Respiratory"],"biosimilarFilings":[],"recentPublications":[{"date":"1976 Apr","pmid":"4613","title":"Dissociation constants and relative efficacies of agonists acting on alpha adrenergic receptors in rabbit aorta.","journal":"The Journal of pharmacology and experimental therapeutics"},{"date":"1958 Jun","pmid":"13533786","title":"Ethylnorepinephrine; a unique bronchodilator.","journal":"American practitioner and digest of treatment"},{"date":"1958","pmid":"13500349","title":"A case of calcified ventricular aneurysm with progressive heart block; observations on the effect of ethylnorepinephrine.","journal":"Cardiologia"},{"date":"1950 May","pmid":"15429016","title":"The pharmacologic action of some analogs of 1-(3,4-dihydroxyphenyl)-2-amino-1-butanol (ethylnorepinephrine).","journal":"The Journal of pharmacology and experimental therapeutics"},{"date":"1948 Jan","pmid":"18917406","title":"Spirometric evaluation of ethyl-nor-epinephrine in bronchial asthma.","journal":"The Journal of allergy"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Butanefrine is a small molecule medication that activates both α and β adrenergic receptors. It is a sympathomimetic and bronchodilator medication related to norepinephrine, sold under various brand names including Etanor, Bronkephrine, and Butanefrine.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}