{"id":"ethylmorphine","rwe":[{"pmid":"37386201","year":"2023","title":"Conductive vial electromembrane extraction of opioids from oral fluid.","finding":"","journal":"Analytical and bioanalytical chemistry","studyType":"Clinical Study"},{"pmid":"37373147","year":"2023","title":"Antioxidant and Hepatoprotective Potential of Echinops ritro L. Extracts on Induced Oxidative Stress In Vitro/In Vivo.","finding":"","journal":"International journal of molecular sciences","studyType":"Clinical Study"},{"pmid":"35305998","year":"2022","title":"On 'Evidence for the participation of cytochrome b5 in hepatic microsomal mixed-function oxidation reactions' by Alfred Hildebrandt and Ronald W. Estabrook.","finding":"","journal":"Archives of biochemistry and biophysics","studyType":"Clinical Study"},{"pmid":"34652878","year":"2022","title":"Synthesis, characterization, method development, and validation of nor-ethylmorphine hydrochloride reference material using established analytical techniques for dope control analysis.","finding":"","journal":"Drug testing and analysis","studyType":"Clinical Study"},{"pmid":"34427950","year":"2022","title":"Medical prescription forms of opioid cough suppressants falsified by the patients before and after they switched from over-the-counter to prescription-only in France.","finding":"","journal":"British journal of clinical pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"ethylmorphine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"R05DA01","category":"atc"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Opioid","category":"pharmacology"},{"label":"Antitussive Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Narcotics","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Respiratory System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dionine","offLabel":[],"synonyms":["ethylmorphine","codethyline","ethomorphine","dionine"],"timeline":[],"approvals":[],"brandName":"Dionine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"ethylmorphine","explanation":"Imagine your brain has special locks that control pain and feelings of well-being. Dionine is a key that fits into these locks, helping to reduce pain and produce feelings of relaxation. However, because its exact target and mechanism are unknown, more research is needed to fully understand how it works.","oneSentence":"Dionine works by interacting with opioid receptors in the brain.","technicalDetail":"Dionine is a mu-opioid receptor agonist, which means it binds to and activates these receptors, producing analgesic and euphoric effects."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Ethylmorphine","title":"Ethylmorphine","extract":"Ethylmorphine is an opioid analgesic and antitussive.","wiki_society_and_culture":"==Society and culture==\nEthylmorphine was first marketed in France in 1953 by Houde, and in Norway and Spain in 1960. It is not marketed in the United States and is a Schedule II controlled substance."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3207","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ethylmorphine","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Ethylmorphine","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T11:16:50.889282","biosimilars":[],"competitors":[{"drugName":"hydrocodone","drugSlug":"hydrocodone","fdaApproval":"1943-03-23","patentExpiry":"Sep 13, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"codeine","drugSlug":"codeine","fdaApproval":"1952-01-21","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"morphine","drugSlug":"morphine","fdaApproval":"","patentExpiry":"Mar 12, 2034","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"dextromethorphan","drugSlug":"dextromethorphan","fdaApproval":"1957-12-03","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"ethylmorphine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"hydrocodone","brandName":"hydrocodone","genericName":"hydrocodone","approvalYear":"1943","relationship":"same-class"},{"drugId":"codeine","brandName":"codeine","genericName":"codeine","approvalYear":"1952","relationship":"same-class"},{"drugId":"morphine","brandName":"morphine","genericName":"morphine","approvalYear":"","relationship":"same-class"},{"drugId":"dextromethorphan","brandName":"dextromethorphan","genericName":"dextromethorphan","approvalYear":"1957","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000167302","NDDF":"003787","UNII":"RWO67D87EU","CHEBI":"CHEBI:4902","RXNORM":"4166","UMLSCUI":"C0015109","ChEMBL_ID":"CHEMBL1712170","KEGG_DRUG":"D07929","DRUGBANK_ID":"DB01466","PUBCHEM_CID":"5359271","SNOMEDCT_US":"74905005","MESH_DESCRIPTOR_UI":"D005036"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":770,"therapeuticAreas":["Pain"],"atcClassification":{"source":"DrugCentral","atcCode":"R05DA01","allCodes":["R05DA01","S01XA06"]},"biosimilarFilings":[],"recentPublications":[{"date":"2023 Sep","pmid":"37386201","title":"Conductive vial electromembrane extraction of opioids from oral fluid.","journal":"Analytical and bioanalytical chemistry"},{"date":"2023 Jun 10","pmid":"37373147","title":"Antioxidant and Hepatoprotective Potential of Echinops ritro L. Extracts on Induced Oxidative Stress In Vitro/In Vivo.","journal":"International journal of molecular sciences"},{"date":"2022 Sep 15","pmid":"35305998","title":"On 'Evidence for the participation of cytochrome b5 in hepatic microsomal mixed-function oxidation reactions' by Alfred Hildebrandt and Ronald W. Estabrook.","journal":"Archives of biochemistry and biophysics"},{"date":"2022 Feb","pmid":"34652878","title":"Synthesis, characterization, method development, and validation of nor-ethylmorphine hydrochloride reference material using established analytical techniques for dope control analysis.","journal":"Drug testing and analysis"},{"date":"2022 Apr","pmid":"34427950","title":"Medical prescription forms of opioid cough suppressants falsified by the patients before and after they switched from over-the-counter to prescription-only in France.","journal":"British journal of clinical pharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Dionine, also known as ethylmorphine, is a small molecule drug belonging to the ethylmorphine class. Its exact target and mechanism of action are unknown, but it is believed to work by interacting with opioid receptors in the brain. Dionine is not FDA-approved for any indications, and its commercial status, including patent and generic availability, is unclear. As a result, key safety considerations and pharmacokinetic properties, such as half-life and bioavailability, are also unknown. Further research is needed to fully understand the properties and potential uses of Dionine.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}