{"id":"ethyl-dibunate","rwe":[{"pmid":"5338382","year":"1967","title":"Antitussive effect of ethyl dibunate in patients with chronic cough.","finding":"","journal":"Clinical pharmacology and therapeutics","studyType":"Clinical Study"},{"pmid":"6031473","year":"1967","title":"Pharmacology of ethyl dibunate, a new antitussive agent.","finding":"","journal":"Archives internationales de pharmacodynamie et de therapie","studyType":"Clinical Study"},{"pmid":"5973161","year":"1966","title":"Metabolism of ethyl dibunate-14C: an antitussive drug.","finding":"","journal":"Biochemical pharmacology","studyType":"Clinical Study"},{"pmid":"14081144","year":"1963","title":"ETHYL DIBUNATE: NEW NON-NARCOTIC FOR ACUTE COUGH.","finding":"","journal":"Pennsylvania medical journal (1928)","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":["NCT05377723","NCT01430130","NCT01399099"],"aliases":[],"patents":[],"pricing":[],"allNames":"neodyne","offLabel":[],"synonyms":["ethyl dibunate","dibunate ethyl","neodyne","tussets"],"timeline":[],"approvals":[],"brandName":"Neodyne","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your body's cells are like a orchestra, and the proteins or receptors are like the musicians. Neodyne is like a conductor that helps the musicians play in harmony, leading to a desired outcome. However, if the conductor is too loud or too soft, it can cause problems, and that's where the safety considerations come in.","oneSentence":"Neodyne works by binding to specific proteins or receptors in the body, altering their function and leading to a therapeutic effect.","technicalDetail":"Neodyne's mechanism of action is likely to involve the modulation of protein-protein interactions or receptor-ligand binding, although the specific details are not well-documented."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Neodymium","title":"Neodymium","extract":"Neodymium is a chemical element; it has symbol Nd and atomic number 60. It is the fourth member of the lanthanide series and is considered to be one of the rare-earth metals. It is a hard, slightly malleable, silvery metal that quickly tarnishes in air and moisture. When oxidized, neodymium reacts quickly, producing pink, purple/blue, and yellow compounds in the +2, +3 and +4 oxidation states. It is generally regarded as having one of the most complex spectra of the elements. Neodymium was discovered in 1885 by the Austrian chemist Carl Auer von Welsbach, who also discovered praseodymium. Neodymium is present in significant quantities in the minerals monazite and bastnäsite. Neodymium is not found naturally in metallic form or unmixed with other lanthanides, and it is usually refined for general use. Neodymium is fairly common—about as common as cobalt, nickel, or copper—and is widely distributed in the Earth's crust. Most of the world's commercial neodymium is mined in China, as is the case with many other rare-earth metals.","wiki_history":"==History==\nupright=0.9|thumb|[[Carl Auer von Welsbach (1858–1929), who discovered neodymium in 1885]]\n\nIn 1751, the Swedish mineralogist Axel Fredrik Cronstedt discovered a heavy mineral from the mine at Bastnäs, later named cerite. Thirty years later, fifteen-year-old Wilhelm Hisinger, a member of the family owning the mine, sent a sample to Carl Scheele, who did not find any new elements within. In 1803, after Hisinger had become an ironmaster, he returned to the mineral with Jöns Jacob Berzelius and isolated a new oxide, which they named ceria after the dwarf planet Ceres, which had been discovered two years earlier. Ceria was simultaneously and independently isolated in Germany by Martin Heinrich Klaproth. Between 1839 and 1843, ceria was shown to be a mixture of oxides by the Swedish surgeon and chemist Carl Gustaf Mosander, who lived in the same house as Berzelius; he separated out two other oxides, which he named lanthana and didymia. He partially decomposed a sample of cerium nitrate by roasting it in air and then treating the resulting oxide with dilute nitric acid. The metals that formed these oxides were thus named lanthanum and didymium. Didymium was later proven to not be a single element when it was split into two elements, praseodymium and neodymium, by Carl Auer von Welsbach in Vienna in 1885.<!-- The year of discovery is wrong in this book. Confirmed by an email from the author--> Von Welsbach confirmed the separation by spectroscopic analysis, but the products were of relatively low purity. Pure neodymium was first isolated in 1925. The name neodymium is derived from the Greek words neos (νέος), new, and didymos (διδύμος), twin.\n\nDouble nitrate crystallization was the means of commercial neodymium purification until the 1950s. Lindsay Chemical Division was the first to commercialize large-scale ion-exchange purification of neodymium. Starting in the 1950s, high purity (>99%) neodymium was primarily obtained through an ion exchange process from mon"},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3197","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ETHYL DIBUNATE","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Neodymium","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T11:16:34.056372","biosimilars":[],"competitors":[],"dataSources":[{"url":"https://clinicaltrials.gov","name":"ClinicalTrials.gov","fields":["trialDetails","trials"],"retrievedDate":"2026-04-07"},{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"ethyl dibunate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT05377723","phase":"NA","title":"Abdominal Scar Improvement in Microsurgical Breast Reconstruction","status":"ACTIVE_NOT_RECRUITING","sponsor":"Stanford University","isPivotal":false,"enrollment":30,"indication":"Cicatrix, Breast Reconstruction","completionDate":"2026-04"},{"nctId":"NCT01430130","phase":"NA","title":"Investigation of a Novel Mechanomodulating Polymer to Maximize the Outcomes of Scar Revision Procedures","status":"COMPLETED","sponsor":"Neodyne Biosciences, Inc.","isPivotal":false,"enrollment":12,"indication":"Hypertrophic","completionDate":"2012-11"},{"nctId":"NCT01399099","phase":"NA","title":"Scar Prevention and the Clinical Effectiveness of a Novel Mechanomodulating Polymer","status":"COMPLETED","sponsor":"Neodyne Biosciences, Inc.","isPivotal":false,"enrollment":67,"indication":"Hypertrophic","completionDate":"2013-03"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"357SRL1981","CHEBI":"CHEBI:135476","INN_ID":"1194","UMLSCUI":"C5238071","ChEMBL_ID":"CHEMBL2106606","KEGG_DRUG":"D04089","PUBCHEM_CID":"21721"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":4,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"1967 May-Jun","pmid":"5338382","title":"Antitussive effect of ethyl dibunate in patients with chronic cough.","journal":"Clinical pharmacology and therapeutics"},{"date":"1967 Feb","pmid":"6031473","title":"Pharmacology of ethyl dibunate, a new antitussive agent.","journal":"Archives internationales de pharmacodynamie et de therapie"},{"date":"1966 Aug","pmid":"5973161","title":"Metabolism of ethyl dibunate-14C: an antitussive drug.","journal":"Biochemical pharmacology"},{"date":"1963 Nov","pmid":"14081144","title":"ETHYL DIBUNATE: NEW NON-NARCOTIC FOR ACUTE COUGH.","journal":"Pennsylvania medical journal (1928)"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Neodyne Biosciences, Inc. is conducting a study on a novel silicone dressing, known as the Neodyne Device, to minimize scar formation. The study is focused on conditions such as hypertrophic scars, cicatrix, and breast reconstruction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}