{"id":"ethyl-chloride-spray","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation or erythema"},{"rate":null,"effect":"Temporary numbness"},{"rate":null,"effect":"Frostbite (with prolonged application)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"When sprayed onto skin, ethyl chloride rapidly evaporates, causing intense cooling that numbs the area and reduces pain sensation. This mechanism makes it useful as a topical anesthetic for minor procedures, injections, and localized pain relief. The cooling effect also has mild anti-inflammatory properties.","oneSentence":"Ethyl chloride spray produces rapid local cooling and numbing of skin through evaporative cooling and topical anesthetic action.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:45:59.747Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical anesthesia for minor surgical procedures and injections"},{"name":"Localized pain relief and numbing prior to venipuncture or minor medical procedures"}]},"trialDetails":[{"nctId":"NCT06596486","phase":"","title":"A Comparison of CoolStick With Ethyl Chloride for the Assessment of Light Touch","status":"COMPLETED","sponsor":"Barts & The London NHS Trust","startDate":"2025-04-01","conditions":"Anesthesia","enrollment":64},{"nctId":"NCT06865170","phase":"PHASE4","title":"Pain Perception During Intra-Articular Knee Joint Injection: What is the Effect of Needle Gauge and the Use of Ethyl 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Hershey Medical Center","startDate":"2016-02-01","conditions":"Shoulder Pain","enrollment":19},{"nctId":"NCT03054740","phase":"PHASE4","title":"Vapocoolant Spray Used Prior to Intravenous (IV) Insertions","status":"COMPLETED","sponsor":"Aultman Health Foundation","startDate":"2017-02-27","conditions":"Pain","enrollment":30},{"nctId":"NCT03140293","phase":"EARLY_PHASE1","title":"Pain Perception During Chorionic Villus Sampling","status":"COMPLETED","sponsor":"Angela Bianco","startDate":"2016-09","conditions":"Chorionic Villi Sampling","enrollment":120},{"nctId":"NCT02651207","phase":"","title":"Ethyl Chloride Spray Versus Subcutaneous Lidocaine Anaesthetic Prior to Contraceptive Implant Insertion","status":"WITHDRAWN","sponsor":"Tayside Medical Science Centre","startDate":"2016-11","conditions":"Contraception","enrollment":""},{"nctId":"NCT02770690","phase":"PHASE4","title":"the Effect of Spray on Propofol Injection Pain","status":"COMPLETED","sponsor":"The Catholic University of Korea","startDate":"2016-04","conditions":"Pain","enrollment":90},{"nctId":"NCT01606046","phase":"PHASE4","title":"Comparison of the Effects of Vapocoolant Spray and EMLA Cream on Pain During Needle Electromyography","status":"COMPLETED","sponsor":"The Catholic University of Korea","startDate":"2011-07","conditions":"Electrodiagnosis","enrollment":99},{"nctId":"NCT01576770","phase":"PHASE4","title":"In Children, Does Using a Synera Patch Decrease Pain When Injecting Propofol at Anesthesia Induction?","status":"UNKNOWN","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2012-04","conditions":"Pain on Propofol IV Injection","enrollment":80},{"nctId":"NCT01292850","phase":"","title":"Skin Sterility After Ethyl-Chloride Spray","status":"COMPLETED","sponsor":"University of Medicine and Dentistry of New Jersey","startDate":"2009-02","conditions":"Skin Sterility After Use of Ethyl-chloride Spray.","enrollment":15},{"nctId":"NCT00720824","phase":"NA","title":"Reduction of Immunization Discomfort in Children","status":"COMPLETED","sponsor":"Berberich, F. Ralph, M.D.","startDate":"2007-06","conditions":"Pain","enrollment":42}],"_emaApprovals":[],"_faersSignals":[{"count":2,"reaction":"FALL"},{"count":2,"reaction":"HEAD INJURY"},{"count":1,"reaction":"DISEASE PROGRESSION"},{"count":1,"reaction":"MEDICATION ERROR"}],"_approvalHistory":[],"publicationCount":79,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["spray","Bethamethasone"],"phase":"marketed","status":"active","brandName":"ethyl chloride spray","genericName":"ethyl chloride spray","companyName":"The Catholic University of Korea","companyId":"the-catholic-university-of-korea","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ethyl chloride spray produces rapid local cooling and numbing of skin through evaporative cooling and topical anesthetic action. Used for Topical anesthesia for minor surgical procedures and injections, Localized pain relief and numbing prior to venipuncture or minor medical procedures.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}