{"id":"ethyl-chloride","rwe":[{"pmid":"41441245","year":"2025","title":"Validated Matrix Matched Quantification of Ethyl Chloride in Postmortem Biological Samples Using HS-GC-FID: Lung as the Optimal Tissue and Temporal Detection Dynamics.","finding":"","journal":"Toxics","studyType":"Clinical Study"},{"pmid":"41345621","year":"2025","title":"Comparative evaluation of clinical performance of bulk-fill composites with incrementally layered conventional composites.","finding":"","journal":"BMC oral health","studyType":"Clinical Study"},{"pmid":"41289981","year":"2026","title":"Comparing ethyl chloride and 10% lignocaine spray for pediatric intravenous cannulation pain relief.","finding":"","journal":"Clinical and experimental pediatrics","studyType":"Clinical Study"},{"pmid":"41277056","year":"2026","title":"Effect of ethyl chloride spray on pain, patient & nurse satisfaction, and adverse effects during IV cannulation: randomized control trial.","finding":"","journal":"Pain management","studyType":"Clinical Study"},{"pmid":"40686410","year":"2025","title":"Microbial safety of vapocoolant spray on sites for arterial line and epidural placement.","finding":"","journal":"British journal of nursing (Mark Allen Publishing)","studyType":"Clinical Study"}],"tags":[{"label":"ethyl chloride","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N01BX01","category":"atc"},{"label":"Active","category":"status"},{"label":"Local anesthesia","category":"indication"},{"label":"Anesthetics","category":"pharmacology"},{"label":"Anesthetics, Local","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"discontinued","safety":{"contraindications":["Cryoglobulinemia"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"chelen","offLabel":[],"synonyms":["ethyl chloride","chelen","chloroethane"],"timeline":[],"approvals":[],"brandName":"Chelen","ecosystem":[{"indication":"Local anesthesia","otherDrugs":[{"name":"amobarbital","slug":"amobarbital","company":""},{"name":"benzalkonium","slug":"benzalkonium","company":""},{"name":"benzocaine","slug":"benzocaine","company":""},{"name":"bupivacaine","slug":"bupivacaine","company":"Hospira"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"ethyl chloride","explanation":"When applied to the skin, ethyl chloride quickly numbs the area by blocking the sodium channels in nerve cells. This prevents the nerve cells from sending pain signals to the brain, making the area feel numb and pain-free. This effect is temporary and wears off once the ethyl chloride is metabolized and eliminated from the body.","oneSentence":"Ethyl chloride works by blocking sodium channels in nerve cells, preventing the transmission of pain signals to the brain.","technicalDetail":"Ethyl chloride exerts its anesthetic effect by reversibly blocking voltage-gated sodium channels, specifically the Nav1.7 and Nav1.8 subtypes, which are responsible for the transmission of pain signals in the peripheral nervous system."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3196","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=ETHYL%20CHLORIDE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ETHYL CHLORIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:08:22.827268","biosimilars":[],"competitors":[{"drugName":"dyclonine","drugSlug":"dyclonine","fdaApproval":"","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"phenol","drugSlug":"phenol","fdaApproval":"","relationship":"same-class"},{"drugName":"capsaicin","drugSlug":"capsaicin","fdaApproval":"2009-11-16","patentExpiry":"Mar 26, 2030","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"ethyl chloride","indications":{"approved":[{"name":"Local 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It is not clear who originally developed the compound, but its current status is not publicly available. Chelen is approved for use in local anesthesia, but its commercial status and other details are unknown. As a local anesthetic, it works by numbing the area where it is applied, preventing pain signals from being transmitted to the brain. Further information on its development, approval, and safety is not available.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}