{"id":"ethyl-biscoumacetate","rwe":[{"pmid":"36993208","year":"2023","title":"Identification of promising high-affinity inhibitors of SARS-CoV-2 main protease from African Natural Products Databases by Virtual Screening.","finding":"","journal":"Research square","studyType":"Clinical Study"},{"pmid":"32471205","year":"2020","title":"Prediction of Novel Inhibitors of the Main Protease (M-pro) of SARS-CoV-2 through Consensus Docking and Drug Reposition.","finding":"","journal":"International journal of molecular sciences","studyType":"Clinical Study"},{"pmid":"7874379","year":"1994","title":"Pharmacokinetics of ethyl biscoumacetate and its metabolite 7-hydroxy ethyl biscoumacetate in healthy volunteers.","finding":"","journal":"International journal of clinical pharmacology and therapeutics","studyType":"Clinical Study"},{"pmid":"8351679","year":"1993","title":"[Effect of dimethicone on pharmacokinetics and pharmacodynamics of ethyl biscoumacetate].","finding":"","journal":"Therapie","studyType":"Clinical Study"},{"pmid":"1629290","year":"1992","title":"Determination of ethyl biscoumacetate and its metabolite 7-hydroxyethyl biscoumacetate in human serum by high-performance liquid chromatography and mass spectrometry.","finding":"","journal":"Journal of chromatography","studyType":"Clinical Study"}],"tags":[{"label":"ethyl biscoumacetate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Vitamin K epoxide reductase complex subunit 1","category":"target"},{"label":"VKORC1","category":"gene"},{"label":"B01AA08","category":"atc"},{"label":"Active","category":"status"},{"label":"Anticoagulants","category":"pharmacology"},{"label":"Hematologic Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"trombarin","offLabel":[],"synonyms":["carbethoxydicoumarol","ethyldicoumarol","ethyl biscoumacetate","neodicoumarin","neodicoumarol","neodicumarinum","neodicumarol","trombarin","trombolysan","tromexan ethyl acetate"],"timeline":[],"approvals":[],"brandName":"Trombarin","ecosystem":[],"mechanism":{"target":"Vitamin K epoxide reductase complex subunit 1","targets":[{"gene":"VKORC1","source":"DrugCentral","target":"Vitamin K epoxide reductase complex subunit 1","protein":"Vitamin K epoxide reductase complex subunit 1"}],"modality":"Small Molecule","drugClass":"ethyl biscoumacetate","explanation":"Think of vitamin K as a key that helps blood clot. Trombarin blocks the recycling of this key, which can help prevent excessive blood clotting. This can be beneficial for people with certain bleeding disorders or those at risk of blood clots.","oneSentence":"Trombarin works by inhibiting the enzyme Vitamin K epoxide reductase complex subunit 1, which is involved in the recycling of vitamin K.","technicalDetail":"Trombarin specifically targets VKORC1, a flavin-containing enzyme that is essential for the recycling of vitamin K epoxides to their reduced forms, thereby inhibiting the vitamin K-dependent carboxylation of clotting factors."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1091","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ETHYL BISCOUMACETATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:16:27.356921","biosimilars":[],"competitors":[{"drugName":"dicoumarol","drugSlug":"dicoumarol","fdaApproval":"1944-07-31","relationship":"same-class"},{"drugName":"phenindione","drugSlug":"phenindione","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"warfarin","drugSlug":"warfarin","fdaApproval":"1954-06-08","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"phenprocoumon","drugSlug":"phenprocoumon","fdaApproval":"1957-12-30","patentStatus":"Unknown","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"ethyl biscoumacetate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"dicoumarol","brandName":"dicoumarol","genericName":"dicoumarol","approvalYear":"1944","relationship":"same-class"},{"drugId":"phenindione","brandName":"phenindione","genericName":"phenindione","approvalYear":"","relationship":"same-class"},{"drugId":"warfarin","brandName":"warfarin","genericName":"warfarin","approvalYear":"1954","relationship":"same-class"},{"drugId":"phenprocoumon","brandName":"phenprocoumon","genericName":"phenprocoumon","approvalYear":"1957","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"002083","UNII":"08KL644731","CHEBI":"CHEBI:135659","INN_ID":"325","UMLSCUI":"C0015056","ChEMBL_ID":"CHEMBL2106261","KEGG_DRUG":"D07131","DRUGBANK_ID":"DB08794","PUBCHEM_CID":"54685524","SNOMEDCT_US":"51739000","MESH_DESCRIPTOR_UI":"D005017"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":115,"therapeuticAreas":["Hematology"],"atcClassification":{"source":"DrugCentral","atcCode":"B01AA08","allCodes":["B01AA08"]},"biosimilarFilings":[],"recentPublications":[{"date":"2023 Mar 24","pmid":"36993208","title":"Identification of promising high-affinity inhibitors of SARS-CoV-2 main protease from African Natural Products Databases by Virtual Screening.","journal":"Research square"},{"date":"2020 May 27","pmid":"32471205","title":"Prediction of Novel Inhibitors of the Main Protease (M-pro) of SARS-CoV-2 through Consensus Docking and Drug Reposition.","journal":"International journal of molecular sciences"},{"date":"1994 Nov","pmid":"7874379","title":"Pharmacokinetics of ethyl biscoumacetate and its metabolite 7-hydroxy ethyl biscoumacetate in healthy volunteers.","journal":"International journal of clinical pharmacology and therapeutics"},{"date":"1993 Mar-Apr","pmid":"8351679","title":"[Effect of dimethicone on pharmacokinetics and pharmacodynamics of ethyl biscoumacetate].","journal":"Therapie"},{"date":"1992 Feb 7","pmid":"1629290","title":"Determination of ethyl biscoumacetate and its metabolite 7-hydroxyethyl biscoumacetate in human serum by high-performance liquid chromatography and mass spectrometry.","journal":"Journal of chromatography"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Trombarin, also known as ethyl biscoumacetate, is a small molecule drug that targets Vitamin K epoxide reductase complex subunit 1. It is a member of the ethyl biscoumacetate class and its mechanism of action is not well-documented. As a result, there is limited information available on its approved indications, commercial status, and key safety considerations. Further research is needed to fully understand the properties and potential uses of Trombarin. Its development status and regulatory history are also unclear.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}