{"id":"ethisterone","rwe":[{"pmid":"41373660","year":"2025","title":"Neuroprotective and Antioxidant Properties of Different Novel Steroid-Derived Nitrones and Oximes on Cerebral Ischemia In Vitro.","finding":"","journal":"International journal of molecular sciences","studyType":"Clinical Study"},{"pmid":"41143593","year":"2025","title":"α-Hydroxyalkynyl-protected copper(I) acetelyenediide nanoclusters with anion-dependent photoluminescence.","finding":"","journal":"Nanoscale","studyType":"Clinical Study"},{"pmid":"41099261","year":"2025","title":"Boosting X-Ray Imaging with a Highly Emissive Steroidal Gold Cluster Featuring Aggregation-Induced Circularly Polarized Luminescence.","finding":"","journal":"Small (Weinheim an der Bergstrasse, Germany)","studyType":"Clinical Study"},{"pmid":"40190420","year":"2025","title":"Correction: Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors.","finding":"","journal":"RSC medicinal chemistry","studyType":"Clinical Study"},{"pmid":"39703801","year":"2025","title":"Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors.","finding":"","journal":"RSC medicinal chemistry","studyType":"Clinical Study"}],"tags":[{"label":"ethisterone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Sex hormone-binding globulin","category":"target"},{"label":"SHBG","category":"gene"},{"label":"NR3C1","category":"gene"},{"label":"G03DC04","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_3","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"ethinone","offLabel":[],"synonyms":["ethisterone","aethisteron","anhydrohydroxyprogesterone","anhydroxyprogesterone","ethinone","ethinyltestosterone","ethynyltestosterone","nugestoral","pregneninolone","progestoral"],"timeline":[],"approvals":[],"brandName":"Ethinone","ecosystem":[],"mechanism":{"target":"Sex hormone-binding globulin, Glucocorticoid receptor, Androgen receptor","targets":[{"gene":"SHBG","source":"DrugCentral","target":"Sex hormone-binding globulin","protein":"Sex hormone-binding globulin"},{"gene":"NR3C1","source":"DrugCentral","target":"Glucocorticoid receptor","protein":"Glucocorticoid receptor"}],"modality":"Small Molecule","drugClass":"ethisterone","explanation":"Think of sex hormone-binding globulin like a container that holds onto sex hormones in the body. Ethinone is like a key that fits into this container, changing how many sex hormones are available. This can affect how the body works, especially for people with hormonal imbalances.","oneSentence":"Ethinone works by binding to sex hormone-binding globulin, affecting the levels of sex hormones in the body.","technicalDetail":"Ethinone acts as a competitive inhibitor of sex hormone-binding globulin, thereby increasing the levels of free sex hormones in the body, such as testosterone and estrogen."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1084","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=ETHISTERONE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ETHISTERONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:16:08.261224","biosimilars":[],"competitors":[{"drugName":"norethisterone","drugSlug":"norethisterone","fdaApproval":"1962-05-21","relationship":"same-class"},{"drugName":"etynodiol","drugSlug":"etynodiol","fdaApproval":"1966-03-23","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"ethisterone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"norethisterone","brandName":"norethisterone","genericName":"norethisterone","approvalYear":"1962","relationship":"same-class"},{"drugId":"etynodiol","brandName":"etynodiol","genericName":"etynodiol","approvalYear":"1966","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT04873102","phase":"PHASE2","title":"Danazol for Treatment of Cytopenias in Patients With Cirrhosis","status":"RECRUITING","sponsor":"University of Southern California","startDate":"2024-08-01","conditions":["Cirrhosis, Liver","Cytopenia"],"enrollment":10,"completionDate":"2027-08-01"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NUI":"N0000167418","NDDF":"001302","UNII":"P201BVY1MJ","CHEBI":"CHEBI:34749","INN_ID":"374","RXNORM":"4129","UMLSCUI":"C0015025","ChEMBL_ID":"CHEMBL241694","PUBCHEM_CID":"5284557","SNOMEDCT_US":"126094004","MESH_DESCRIPTOR_UI":"D005003"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":119,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"G03DC04","allCodes":["G03DC04","G03FA03"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 Nov 27","pmid":"41373660","title":"Neuroprotective and Antioxidant Properties of Different Novel Steroid-Derived Nitrones and Oximes on Cerebral Ischemia In Vitro.","journal":"International journal of molecular sciences"},{"date":"2025 Nov 6","pmid":"41143593","title":"α-Hydroxyalkynyl-protected copper(I) acetelyenediide nanoclusters with anion-dependent photoluminescence.","journal":"Nanoscale"},{"date":"2025 Dec","pmid":"41099261","title":"Boosting X-Ray Imaging with a Highly Emissive Steroidal Gold Cluster Featuring Aggregation-Induced Circularly Polarized Luminescence.","journal":"Small (Weinheim an der Bergstrasse, Germany)"},{"date":"2025 Apr 16","pmid":"40190420","title":"Correction: Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors.","journal":"RSC medicinal chemistry"},{"date":"2025 Mar 19","pmid":"39703801","title":"Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors.","journal":"RSC medicinal chemistry"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ethinone, also known as ethisterone, is a small molecule drug in the ethisterone class that targets sex hormone-binding globulin. It is not FDA-approved for any indications, and its commercial status, generic availability, and patent status are unknown. Ethinone works by binding to sex hormone-binding globulin, which affects the levels of sex hormones in the body. As a result, it may be used to treat conditions related to hormonal imbalances. However, due to its unknown status, its use and safety considerations are not well established.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}