{"id":"ethinyl-estradiol-cyprosterone-acetate","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Nausea"},{"rate":"5-15","effect":"Headache"},{"rate":"5-10","effect":"Breast tenderness"},{"rate":"5-10","effect":"Breakthrough bleeding"},{"rate":"5","effect":"Mood changes"},{"rate":"0.3-0.4","effect":"Venous thromboembolism"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The ethinyl estradiol component acts as a synthetic estrogen that inhibits the luteinizing hormone (LH) surge necessary for ovulation. Cyproterone acetate functions as a progestin and androgen receptor antagonist, providing additional contraceptive efficacy through cervical mucus thickening and endometrial changes, while simultaneously blocking androgenic effects. This combination is particularly effective for conditions associated with hyperandrogenism.","oneSentence":"Ethinyl estradiol-cyproterone acetate is an oral contraceptive that suppresses ovulation through combined estrogenic and progestagenic activity while providing anti-androgenic effects.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:32:43.654Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contraception"},{"name":"Acne vulgaris associated with hyperandrogenism"},{"name":"Hirsutism"},{"name":"Polycystic ovary syndrome (PCOS)-related symptoms"}]},"trialDetails":[{"nctId":"NCT03236740","phase":"PHASE4","title":"OCP vs Metformin on Ovarian Stromal Blood Flow in PCOS","status":"COMPLETED","sponsor":"S.C.B. Medical College and Hospital","startDate":"2017-08-01","conditions":"PCOS","enrollment":101}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1313,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ethinyl Estradiol-cyprosterone acetate","genericName":"Ethinyl Estradiol-cyprosterone acetate","companyName":"S.C.B. Medical College and Hospital","companyId":"s-c-b-medical-college-and-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ethinyl estradiol-cyproterone acetate is an oral contraceptive that suppresses ovulation through combined estrogenic and progestagenic activity while providing anti-androgenic effects. Used for Contraception, Acne vulgaris associated with hyperandrogenism, Hirsutism.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}