{"id":"ethinyl-estradiol-and-levogestrel","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Nausea"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Breast tenderness"},{"rate":"5-15","effect":"Breakthrough bleeding"},{"rate":"5","effect":"Mood changes"},{"rate":"0.3-0.4","effect":"Venous thromboembolism"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ethinyl estradiol (a synthetic estrogen) and levonorgestrel (a synthetic progestin) work synergistically to inhibit the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), preventing ovulation. The progestin component also thickens cervical mucus to impede sperm penetration and alters the endometrium to reduce implantation likelihood.","oneSentence":"This combination oral contraceptive prevents pregnancy by suppressing ovulation through hormonal inhibition of the hypothalamic-pituitary-ovarian axis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:36:00.963Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contraception / prevention of pregnancy"}]},"trialDetails":[{"nctId":"NCT00829114","phase":"PHASE4","title":"Interactions Between Antiretrovirals (ARVs) and Combined Oral Contraceptives (COCs)","status":"COMPLETED","sponsor":"FHI 360","startDate":"2009-03","conditions":"HIV/AIDS, HIV Infections","enrollment":370}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"ETHINYL ESTRADIOL AND LEVOGESTREL","genericName":"ETHINYL ESTRADIOL AND LEVOGESTREL","companyName":"FHI 360","companyId":"fhi-360","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination oral contraceptive prevents pregnancy by suppressing ovulation through hormonal inhibition of the hypothalamic-pituitary-ovarian axis. Used for Contraception / prevention of pregnancy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}