{"id":"ethanol-lock-therapy-elt","safety":{"commonSideEffects":[{"rate":null,"effect":"Catheter dysfunction or occlusion"},{"rate":null,"effect":"Local irritation or thrombophlebitis"},{"rate":null,"effect":"Ethanol toxicity (rare, with proper technique)"}]},"_chembl":{"chemblId":"CHEMBL545","moleculeType":"Small molecule","molecularWeight":"46.07"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"ELT works by filling the catheter lumen with 70-100% ethanol between uses, where the ethanol denatures proteins and disrupts bacterial biofilm formation on the catheter surface. This antimicrobial approach reduces catheter-related bloodstream infections (CRBSIs) in patients with long-term central lines, particularly those requiring parenteral nutrition or frequent vascular access.","oneSentence":"Ethanol lock therapy uses a high-concentration ethanol solution instilled into central venous catheters to prevent and treat biofilm-related catheter infections.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:39:23.775Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of catheter-related bloodstream infections (CRBSIs) in patients with central venous catheters"},{"name":"Treatment of catheter-related infections in patients dependent on long-term vascular access"}]},"trialDetails":[{"nctId":"NCT03253887","phase":"PHASE3","title":"Ethanol-lock Therapy for the Prevention of Non-tunneled Catheter-related Infection in Pediatric Patients","status":"COMPLETED","sponsor":"Instituto Materno Infantil Prof. Fernando Figueira","startDate":"2016-03","conditions":"Infection, Catheter-Related, Central Line-associated Bloodstream Infection (CLABSI), Pediatric","enrollment":120},{"nctId":"NCT02095951","phase":"PHASE4","title":"Preemptive Ethanol Lock Therapy in Pediatric Bloodstream Infection","status":"COMPLETED","sponsor":"Children's Hospital of Michigan","startDate":"2014-06","conditions":"Leukemia, Lymphoma, Blood Disorders","enrollment":30},{"nctId":"NCT02227329","phase":"PHASE1, PHASE2","title":"Prophylactic Ethanol Lock Therapy (ELT) in Patients on Home Parenteral Nutrition","status":"TERMINATED","sponsor":"Mayo Clinic","startDate":"2014-07","conditions":"Catheter-related Bloodstream Infection (CRBSI) Nos, Bloodstream Infection Due to Central Venous Catheter, Bloodstream Infection Due to Hickman Catheter","enrollment":39}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["70% Ethanol in water"],"phase":"marketed","status":"active","brandName":"Ethanol lock therapy (ELT)","genericName":"Ethanol lock therapy (ELT)","companyName":"Children's Hospital of Michigan","companyId":"children-s-hospital-of-michigan","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ethanol lock therapy uses a high-concentration ethanol solution instilled into central venous catheters to prevent and treat biofilm-related catheter infections. Used for Prevention of catheter-related bloodstream infections (CRBSIs) in patients with central venous catheters, Treatment of catheter-related infections in patients dependent on long-term vascular access.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}