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This local approach reduces infection risk without systemic drug exposure.","oneSentence":"Ethanol-lock therapy uses a high-concentration ethanol solution instilled into central venous catheters to prevent and treat catheter-related bloodstream infections by antimicrobial action against biofilm-forming organisms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:11:42.716Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of catheter-related bloodstream infections in patients with central venous catheters"},{"name":"Treatment of catheter-related bloodstream infections"}]},"trialDetails":[{"nctId":"NCT07471854","phase":"NA","title":"Efficacy and Safety of Combined Nanofat Injection With Either Platelet Rich Fibrin or Microneedling Versus Nanofat Injection Alone in the Treatment of Facial Atrophic Post Acne Scars","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2026-05-01","conditions":"Acne Scars - Atrophic","enrollment":42},{"nctId":"NCT05106192","phase":"NA","title":"Triamcinolone Acetonide Injections in Primary Cutaneous Lymphoma Plaques With a Novel Needle-free Drug-delivery System.","status":"WITHDRAWN","sponsor":"Case Comprehensive Cancer Center","startDate":"2022-04-01","conditions":"Mycosis Fungoides of Skin (Diagnosis), Cutaneous T-cell Lymphoma, Non Hodgkin Lymphoma","enrollment":""},{"nctId":"NCT02901717","phase":"PHASE3","title":"Mino-Lok Therapy (MLT) for the Treatment of CRBSI/CLABSI","status":"UNKNOWN","sponsor":"Leonard-Meron Biosciences, Inc.","startDate":"2018-02-13","conditions":"Catheter-related Infections","enrollment":144},{"nctId":"NCT03253887","phase":"PHASE3","title":"Ethanol-lock Therapy for the Prevention of Non-tunneled Catheter-related Infection in Pediatric Patients","status":"COMPLETED","sponsor":"Instituto Materno Infantil Prof. Fernando Figueira","startDate":"2016-03","conditions":"Infection, Catheter-Related, Central Line-associated Bloodstream Infection (CLABSI), Pediatric","enrollment":120},{"nctId":"NCT02890875","phase":"NA","title":"Efficacy and Safety of Ethanol Lock Therapy for the Prevention of Central Line-associated Bloodstream Infections","status":"TERMINATED","sponsor":"Stanford University","startDate":"2016-08","conditions":"Catheter-Related Infections","enrollment":3},{"nctId":"NCT02095951","phase":"PHASE4","title":"Preemptive Ethanol Lock Therapy in Pediatric Bloodstream Infection","status":"COMPLETED","sponsor":"Children's Hospital of Michigan","startDate":"2014-06","conditions":"Leukemia, Lymphoma, Blood Disorders","enrollment":30},{"nctId":"NCT02227329","phase":"PHASE1, PHASE2","title":"Prophylactic Ethanol Lock Therapy (ELT) in Patients on Home Parenteral Nutrition","status":"TERMINATED","sponsor":"Mayo Clinic","startDate":"2014-07","conditions":"Catheter-related Bloodstream Infection (CRBSI) Nos, Bloodstream Infection Due to Central Venous Catheter, Bloodstream Infection Due to Hickman Catheter","enrollment":39},{"nctId":"NCT01472965","phase":"PHASE3","title":"Ethanol Lock Therapy for Treatment and Secondary Prophylaxis of Central Line-Associated Bloodstream Infection","status":"COMPLETED","sponsor":"St. Jude Children's Research Hospital","startDate":"2011-12-29","conditions":"Central Line-Associated Bloodstream Infection","enrollment":95},{"nctId":"NCT01263574","phase":"PHASE2","title":"Trial of 70% Ethanol Versus Heparin to Reduce the Rate of Central Line Infections in Children With Short Bowel Syndrome","status":"WITHDRAWN","sponsor":"Boston Children's Hospital","startDate":"2011-02","conditions":"Catheter Related Infections, Short Bowel Syndrome","enrollment":""},{"nctId":"NCT02411331","phase":"NA","title":"Randomized, Multicenter, Double-blind, Vancomycin-controlled Study to Evaluate the Efficacy of Ethanol Lock Solution for the Curative Treatment of Implantable Venous Access Port Infection Due to Coagulase-negative Staphylococci","status":"UNKNOWN","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2015-03","conditions":"Lock Solution, Catheter Related Blood Stream Infections, Central Venous Catheter Infection","enrollment":180},{"nctId":"NCT00948441","phase":"NA","title":"Pediatric Ethanol Lock Therapy Study.","status":"COMPLETED","sponsor":"University of Pittsburgh","startDate":"2008-08","conditions":"Catheter-Related Infections","enrollment":16},{"nctId":"NCT01539343","phase":"PHASE2","title":"Antimicrobial Catheter Lock Solution for the Treatment of Central Line Associated Bloodstream Infection (CLABSI)","status":"COMPLETED","sponsor":"M.D. Anderson Cancer Center","startDate":"2013-04","conditions":"Infection","enrollment":31},{"nctId":"NCT01394458","phase":"NA","title":"Efficacy and Safety of an Ethanol/Sodium Citrate Locking Solution: A Pilot Study","status":"COMPLETED","sponsor":"University of Manitoba","startDate":"2011-08","conditions":"Catheter Related Infection, Bacteremia","enrollment":40},{"nctId":"NCT00875069","phase":"PHASE3","title":"Efficacy and Safety of Ethanol Lock Solution in Prevention of Catheter Related Bloodstream Infection for Patients Suffering Acute Renal Failure, and Hospitalized in Intensive Care Unit. A Multi-Center, Randomized, Versus Placebo, Double Blinded Clinical Trial","status":"COMPLETED","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2009-04","conditions":"Acute Renal Failure, Infection","enrollment":1460},{"nctId":"NCT00680459","phase":"PHASE3","title":"Ethanol Locks for the Treatment of Central Venous Line Infections","status":"TERMINATED","sponsor":"Baystate Medical Center","startDate":"2008-05","conditions":"Bloodstream Infection","enrollment":13},{"nctId":"NCT00471679","phase":"PHASE1","title":"Ethanol-Lock Treatment in Preventing Central Venous Catheter Infections in Patients With High-Risk Neuroblastoma","status":"COMPLETED","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2007-04","conditions":"Neuroblastoma","enrollment":12},{"nctId":"NCT01101412","phase":"PHASE1, PHASE2","title":"Antimicrobial Solution or Saline Solution in Maintaining Catheter Patency and Preventing Catheter-Related Blood Infections in Patients With Malignancies","status":"WITHDRAWN","sponsor":"M.D. Anderson Cancer Center","startDate":"","conditions":"Chronic Myeloproliferative Disorders, Infection, Leukemia","enrollment":""},{"nctId":"NCT01229592","phase":"NA","title":"Ethanol in the Prevention of Central Venous Catheter Infections","status":"TERMINATED","sponsor":"Hospital General Universitario Gregorio Marañon","startDate":"2009-12","conditions":"Catheter Related Infection","enrollment":200},{"nctId":"NCT01186172","phase":"PHASE3","title":"Ethanol Lock for the Salvage of Infected Long-term Vascular Access","status":"UNKNOWN","sponsor":"Fondazione IRCCS Policlinico San Matteo di Pavia","startDate":"2010-06","conditions":"Bacteremia","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":70,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Ethanol-lock therapy","genericName":"Ethanol-lock therapy","companyName":"Fondazione IRCCS Policlinico San Matteo di Pavia","companyId":"fondazione-irccs-policlinico-san-matteo-di-pavia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ethanol-lock therapy uses a high-concentration ethanol solution instilled into central venous catheters to prevent and treat catheter-related bloodstream infections by antimicrobial action against biofilm-forming organisms. Used for Prevention of catheter-related bloodstream infections in patients with central venous catheters, Treatment of catheter-related bloodstream infections.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}