{"id":"ethanol","rwe":[],"_fda":{"id":"4009eb5c-5b54-fd95-e063-6294a90a17f2","set_id":"0398573a-44fa-e0c6-e063-6394a90a9924","openfda":{"unii":["3K9958V90M"],"route":["TOPICAL"],"rxcui":["884787"],"spl_id":["4009eb5c-5b54-fd95-e063-6294a90a17f2"],"brand_name":["Lavender Hand Sanitizer Wipes"],"spl_set_id":["0398573a-44fa-e0c6-e063-6394a90a9924"],"package_ndc":["42681-6808-3"],"product_ndc":["42681-6808"],"generic_name":["ETHANOL"],"product_type":["HUMAN OTC DRUG"],"substance_name":["ALCOHOL"],"manufacturer_name":["Whole Foods Market, Inc."],"application_number":["505G(a)(3)"],"is_original_packager":[true]},"purpose":["Purpose Antimicrobial"],"version":"4","warnings":["Warnings For external use only. Flammable keep away from fire or flame. When using this product do not use in or near eyes, if contact occurs, flush thoroughly with water. Stop use and contact a doctor if irritation or redness persists for more than 72 hours."],"questions":["Questions, Comments? 1-844-WFM-TALK(1-844-936-8255)"],"effective_time":"20250930","active_ingredient":["Active Ingredient Ethyl Alcohol 65% v/v"],"inactive_ingredient":["Inactive ingredients Aloe Barbadensis Leaf Extract Althaea Officinalis Root Extract Avena Sativa (Oat) Kernel Extract Camellia Sinensis Leaf Extract Chamomilla Recutita (Matricaria) Flower Extract Cucumis Sativus (Cucumber) Fruit Extract Glycerin, Isopropyl alcohol, Lavandula Angustifolia(Lavender) Oil, Water."],"indications_and_usage":["Uses • for hand sanitizing to decrease bacteria on skin when water and soap are not avaliable • recommended for repeated use"],"dosage_and_administration":["Directions • remove and unfold wipe •wet hands thoroughly with product and let air dry"],"spl_product_data_elements":["Lavender Hand Sanitizer Wipes Ethanol ALCOHOL ALCOHOL OAT KERNEL OIL WATER ALOE VERA LEAF ALTHAEA OFFICINALIS ROOT GLYCERIN TEA LEAF MATRICARIA CHAMOMILLA FLOWERING TOP CUCUMIS SATIVUS WHOLE ISOPROPYL ALCOHOL LAVENDER OIL"],"keep_out_of_reach_of_children":["Keep out of reach of children Keep out of reach of children . If swallowed, get medical help or contact a Poison Control Center right away"],"package_label_principal_display_panel":["Label NDC 42681-6808-3 365 WHOLE FOODS MARKET REFRESHING WIPES Hand Sanitizer Lavender 99.9% effective against most common germs* Made without Benzalkonium Chloride PEEL & SEAL DO NOT FLUSH 10 WIPES 6IN x 7.5IN (15.25cm x 19.05cm) DISTRIBUTED BY: WHOLE FOODS MARKET AUSTIN, TX 78703 2020 WHOLE FOODS MARKET IP, LP www.wholefoodsmarket.com WARNING: THESE WIPES CONTAIN ALCOHOL, WHICH CAN DISCOLOR SOME FABRICS AND SURFACES. ALWAYS TEST AN INCONSPICUOUS SPOT FIRST. DISCLAIMER: ALCOHOL EVAPORATES WITH TIME. TO KEEP THESE WIPES FRESH AND EFFECTIVE, RESEAL SECURELY AFTER EACH USE AND STORE AT 75F OR BELOW. KEEP OUT OF DIRECT SUNLIGHT. DISCARD AFTER USE. DO NOT FLUSH. *ESCHERICHIA COLI, STAPHYLOCOCCUS AUREUS, SALMONELLA TYPHIMURIUM, PSEUDOMONAS AERUGINOSA, BURKHOLDERIA CEPACIA, ENTEROBACTER CLOACAE, ENTEROCOCCUS FAECALIS, STREPTOCOCCUS PYOGENES, CANDIDA ALBICANS, ASPERGILLUS BRASILIENSIS. Made Without: Benzalkonium Chloride, Parabens or Triclosan Glycerin & Aloe Vera to replace moisture 99.9% effective against most common germs* Lavender Essential Oil FSC MIX Paper FSC C109834 UPC 099482468088 Seal Label LABEL"]},"tags":[{"label":"ethanol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"GABA A receptor alpha-4/beta-2/delta","category":"target"},{"label":"GABRA4","category":"gene"},{"label":"GABRB2","category":"gene"},{"label":"GABRD","category":"gene"},{"label":"D08AX08","category":"atc"},{"label":"Extracorporeal","category":"route"},{"label":"Topical","category":"route"},{"label":"Aerosol","category":"form"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Antiseptic preparation","category":"indication"},{"label":"Qol Medcl","category":"company"},{"label":"Approved 1940s","category":"decade"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Anti-Infective Agents, Local","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Solvents","category":"pharmacology"}],"phase":"marketed","safety":{"boxedWarnings":[],"safetySignals":[{"date":"","signal":"COMPLETED SUICIDE","source":"FDA FAERS","actionTaken":"2795 reports"},{"date":"","signal":"TOXICITY TO VARIOUS AGENTS","source":"FDA FAERS","actionTaken":"1744 reports"},{"date":"","signal":"DRUG ABUSE","source":"FDA FAERS","actionTaken":"1625 reports"},{"date":"","signal":"DEATH","source":"FDA FAERS","actionTaken":"1131 reports"},{"date":"","signal":"CARDIAC ARREST","source":"FDA FAERS","actionTaken":"841 reports"},{"date":"","signal":"CARDIO-RESPIRATORY ARREST","source":"FDA FAERS","actionTaken":"806 reports"},{"date":"","signal":"RESPIRATORY ARREST","source":"FDA FAERS","actionTaken":"762 reports"},{"date":"","signal":"POISONING","source":"FDA FAERS","actionTaken":"616 reports"},{"date":"","signal":"INTENTIONAL DRUG MISUSE","source":"FDA FAERS","actionTaken":"415 reports"},{"date":"","signal":"OVERDOSE","source":"FDA FAERS","actionTaken":"415 reports"}],"drugInteractions":[{"url":"/drug/disulfiram","drug":"disulfiram","action":"Monitor closely","effect":"May interact with Alcohol, Disulfiram","source":"DrugCentral","drugSlug":"disulfiram"},{"url":"/drug/methotrexate","drug":"methotrexate","action":"Monitor closely","effect":"May interact with Alcohol, Methotrexate","source":"DrugCentral","drugSlug":"methotrexate"},{"url":"/drug/metronidazole","drug":"metronidazole","action":"Monitor closely","effect":"May interact with Alcohol, Metronidazole","source":"DrugCentral","drugSlug":"metronidazole"}],"commonSideEffects":[{"effect":"Diarrhea","drugRate":"","severity":"moderate","organSystem":""},{"effect":"Nausea","drugRate":"","severity":"moderate","organSystem":""},{"effect":"Rash","drugRate":"","severity":"moderate","organSystem":""},{"effect":"Headache","drugRate":"","severity":"moderate","organSystem":""},{"effect":"Abdominal pain","drugRate":"","severity":"moderate","organSystem":""},{"effect":"Vomiting","drugRate":"","severity":"moderate","organSystem":""}],"specialPopulations":{"Pregnancy":"If pregnant or breast feeding,. ask health professional before use.","Geriatric use":"To decrease bacteria on the skin that could cause disease. Recommended for repeated use.","Paediatric use":"Safety and effectiveness in pediatric patients have not been established."},"seriousAdverseEvents":[{"effect":"Toxic epidermal necrolysis","drugRate":"","severity":"serious"},{"effect":"Acute generalized exanthematous pustulosis","drugRate":"","severity":"serious"},{"effect":"Drug rash with eosinophilia and systemic symptoms","drugRate":"","severity":"serious"},{"effect":"Hepatotoxicity","drugRate":"","severity":"serious"},{"effect":"Rhabdomyolysis","drugRate":"","severity":"serious"},{"effect":"Crystal nephropathy","drugRate":"","severity":"serious"},{"effect":"Crystalluria","drugRate":"","severity":"serious"},{"effect":"Renal impairment","drugRate":"","severity":"serious"},{"effect":"Immune Reconstitution Syndrome","drugRate":"","severity":"serious"},{"effect":"Redistribution of body fat","drugRate":"","severity":"serious"}]},"trials":[],"aliases":["Ethyl Alcohol","Ehtyol","Ethamolin","oral ethanol","oral placebo ethanol"],"company":"Qol Medcl","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=Ethanol","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:26:55.134923+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Ethanol","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-20T03:27:03.457888+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:27:01.680203+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Ethanol","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:27:02.445704+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:26:52.918679+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:26:52.918747+00:00"},"safety.safetySignals":{"url":"https://api.fda.gov/drug/event.json","method":"api_direct","source":"FDA FAERS","rawText":"","confidence":1,"sourceType":"fda_faers","retrievedAt":"2026-04-20T03:27:04.365293+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL545/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:27:03.348473+00:00"},"regulatory.fda_application":{"url":"","method":"deterministic","source":"FDA Label","rawText":"505G(a)(3)","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:26:52.918758+00:00"}},"allNames":"ablysinol","offLabel":[],"synonyms":["alcohol","ethanol","ethyl alcohol","grain alcohol"],"timeline":[{"date":"1946-01-01","type":"neutral","source":"FDA Orange Book","milestone":"Rights transferred from B BRAUN to Qol Medcl"}],"aiSummary":"Ablysinol, also known as ethanol, is a small molecule drug originally developed by B BRAUN and currently owned by Qol Medcl. It targets the GABA A receptor alpha-4/beta-2/delta, modulating its activity. Ablysinol is FDA-approved for use as an antiseptic preparation, with an 80% bioavailability. It is off-patent, meaning it is no longer protected by patents, and there are no generic manufacturers. As a result, its commercial status is limited.","approvals":[{"date":"1946-01-17","orphan":false,"company":"B BRAUN","regulator":"FDA"}],"brandName":"Ablysinol","ecosystem":[{"indication":"Antiseptic preparation","otherDrugs":[{"name":"boric acid","slug":"boric-acid","company":""},{"name":"chloroxylenol","slug":"chloroxylenol","company":""},{"name":"hydrogen peroxide","slug":"hydrogen-peroxide","company":""},{"name":"isopropanol","slug":"isopropanol","company":""}],"globalPrevalence":null}],"mechanism":{"target":"GABA A receptor alpha-4/beta-2/delta","novelty":"First-in-class","targets":[{"gene":"GABRA4","source":"DrugCentral","target":"GABA A receptor alpha-4/beta-2/delta","protein":"Gamma-aminobutyric acid receptor subunit alpha-4"},{"gene":"GABRB2","source":"DrugCentral","target":"GABA A receptor alpha-4/beta-2/delta","protein":"Gamma-aminobutyric acid receptor subunit beta-2"},{"gene":"GABRD","source":"DrugCentral","target":"GABA A receptor alpha-4/beta-2/delta","protein":"Gamma-aminobutyric acid receptor subunit delta"},{"gene":"GRIN3A","source":"DrugCentral","target":"Glutamate receptor ionotropic, NMDA 3A","protein":"Glutamate receptor ionotropic, NMDA 3A"},{"gene":"GLRA1","source":"DrugCentral","target":"Glycine receptor subunit alpha-1","protein":"Glycine receptor subunit alpha-1"},{"gene":"GLRA2","source":"DrugCentral","target":"Glycine receptor subunit alpha-2","protein":"Glycine receptor subunit alpha-2"}],"modality":"Small Molecule","drugClass":"ethanol","explanation":"","oneSentence":"","technicalDetail":"Ablysinol acts as a positive allosteric modulator of the GABA A receptor, enhancing its inhibitory effects on neuronal activity through the alpha-4/beta-2/delta subunit combination."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Ethanol","title":"Ethanol","extract":"Ethanol is an organic compound with the chemical formula CH3CH2OH. It is an alcohol, with its formula also written as C2H5OH, C2H6O or EtOH, where Et is the pseudoelement symbol for ethyl. Ethanol is a volatile, flammable, colorless liquid with a pungent taste. As a psychoactive depressant, it is the active ingredient in alcoholic beverages, and the second most consumed drug globally behind caffeine.","wiki_history":"== History ==\n<!--\nthumb|upright|Ethanol being used as fuel for a burner-->\n\nThe fermentation of sugar into ethanol is one of the earliest biotechnologies employed by humans. Ethanol has historically been identified variously as spirit of wine or ardent spirits, and as aqua vitae (Latin for \"water of life\") or aqua vita. The intoxicating effects of its consumption have been known since ancient times. Ethanol has been used by humans since prehistory as the intoxicating ingredient of alcoholic beverages. Dried residue on 9,000-year-old pottery found in China suggests that Neolithic people consumed alcoholic beverages.\n\nThe inflammable nature of the exhalations of wine was already known to ancient natural philosophers such as Aristotle (384–322 BCE), Theophrastus (–287 BCE), and Pliny the Elder (23/24–79 CE). However, this did not immediately lead to the isolation of ethanol, despite the development of more advanced distillation techniques in second- and third-century Roman Egypt. An important recognition, first found in one of the writings attributed to Jābir ibn Ḥayyān (ninth century CE), was that by adding salt to boiling wine, which increases the wine's relative volatility, the flammability of the resulting vapors may be enhanced. The distillation of wine is attested in Arabic works attributed to al-Kindī (–873 CE) and to al-Fārābī (–950), and in the 28th book of al-Zahrāwī's (Latin: Abulcasis, 936–1013) Kitāb al-Taṣrīf (later translated into Latin as Liber servatoris). In the twelfth century, recipes for the production of aqua ardens (\"burning water\", i.e., ethanol) by distilling wine with salt started to appear in a number of Latin works, and by the end of the thirteenth century it had become a widely known substance among Western European chemists.\n\nThe works of Taddeo Alderotti (1223–1296) describe a method for concentrating ethanol involving repeated fractional distillation through a water-cooled still, by which an ethanol purity of 90% could be obtained. The "},"commercial":{"launchDate":"1946","_launchSource":"DrugCentral (FDA 1946-01-17, B BRAUN)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1076","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=Ethanol","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Ethanol","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Ethanol","fields":["history","overview"],"source":"Wikipedia"},{"id":5,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T11:06:47.001055","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T03:27:06.088047+00:00","fieldsConflicting":2,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"hydrogen peroxide","drugSlug":"hydrogen-peroxide","fdaApproval":"","patentExpiry":"Jul 4, 2035","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"tosylchloramide sodium","drugSlug":"tosylchloramide-sodium","fdaApproval":"","relationship":"same-class"},{"drugName":"isopropanol","drugSlug":"isopropanol","fdaApproval":"","relationship":"same-class"},{"drugName":"sodium hypochlorite","drugSlug":"sodium-hypochlorite","fdaApproval":"","relationship":"same-class"}],"genericName":"ethanol","indications":{"approved":[{"name":"Antiseptic preparation","source":"DrugCentral","snomedId":261276004,"regulator":"FDA","eligibility":"No specific patient eligibility criteria mentioned"}],"offLabel":[],"pipeline":[]},"currentOwner":"Qol Medcl","drugCategory":"active","labelChanges":[],"patentStatus":"Off-patent — no active Orange Book patents","relatedDrugs":[{"drugId":"hydrogen-peroxide","brandName":"hydrogen peroxide","genericName":"hydrogen peroxide","approvalYear":"","relationship":"same-class"},{"drugId":"tosylchloramide-sodium","brandName":"tosylchloramide sodium","genericName":"tosylchloramide sodium","approvalYear":"","relationship":"same-class"},{"drugId":"isopropanol","brandName":"isopropanol","genericName":"isopropanol","approvalYear":"","relationship":"same-class"},{"drugId":"sodium-hypochlorite","brandName":"sodium hypochlorite","genericName":"sodium hypochlorite","approvalYear":"","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT02108080","phase":"","title":"Characterization Imaging Instruments in Alcoholics and Non-Alcoholics","status":"RECRUITING","sponsor":"National Institute on Alcohol Abuse and Alcoholism (NIAAA)","startDate":"2014-07-10","conditions":["Alcohol Dependence","Alcohol 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Lymphoma","Hodgkin Lymphoma"],"enrollment":49,"completionDate":"2027-04-30"},{"nctId":"NCT07221383","phase":"NA","title":"LDART for Alcohol Use Disorder","status":"NOT_YET_RECRUITING","sponsor":"Yale University","startDate":"2026-04-01","conditions":["Alcohol Use Disorder","Hazardous Alcohol Use"],"enrollment":80,"completionDate":"2027-04-01"},{"nctId":"NCT02181569","phase":"","title":"Sleep Disturbance and Relapse in Individuals With Alcohol Dependence: An Exploratory Mixed Methods Study","status":"COMPLETED","sponsor":"National Institutes of Health Clinical Center (CC)","startDate":"2014-07-10","conditions":["Alcoholism"],"enrollment":198,"completionDate":"2019-03-04"},{"nctId":"NCT07494968","phase":"NA","title":"Defining Objective Markers of Compliance for Dietary Therapies in IBS","status":"NOT_YET_RECRUITING","sponsor":"University of Michigan","startDate":"2026-04","conditions":["Irritable Bowel 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