{"id":"ethadione","rwe":[{"pmid":"13970793","year":"1962","title":"Renal histology during treatment with oxazolidine-diones (trimethadione, ethadione, and paramethadione).","finding":"","journal":"Pediatrics","studyType":"Clinical Study"}],"tags":[{"label":"ethadione","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N03AC03","category":"atc"},{"label":"Active","category":"status"},{"label":"Absence seizure","category":"indication"},{"label":"Epilepsy","category":"indication"}],"phase":"unknown","safety":{"contraindications":["Acute nephropathy","Disease of liver","Disorder of optic nerve","Eaton-Lambert syndrome","Hepatic failure","Kidney disease","Leukopenia","Lupus erythematosus and erythema multiforme-like syndrome","Lymphadenopathy","Neutropenic disorder","Porphyria","Pregnancy, function","Proteinuria","Retinal disorder","Thrombocytopenic disorder"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"didione","offLabel":[],"synonyms":["ethadione","aethadion","didione","dimedion","dimedione","ethadionum","petidion"],"timeline":[],"approvals":[],"brandName":"Didione","ecosystem":[{"indication":"Absence seizure","otherDrugs":[{"name":"acetazolamide","slug":"acetazolamide","company":"Teva Branded Pharm"},{"name":"clonazepam","slug":"clonazepam","company":"Roche"},{"name":"ethosuximide","slug":"ethosuximide","company":"Parke Davis"},{"name":"lorazepam","slug":"lorazepam","company":"Valeant Intl"}],"globalPrevalence":null},{"indication":"Epilepsy","otherDrugs":[{"name":"amobarbital","slug":"amobarbital","company":""},{"name":"carbamazepine","slug":"carbamazepine","company":"Novartis"},{"name":"diazepam","slug":"diazepam","company":"Roche"},{"name":"felbamate","slug":"felbamate","company":"Meda Pharms"}],"globalPrevalence":50000000}],"mechanism":{"modality":"Small Molecule","drugClass":"ethadione","explanation":"Think of it like a dimmer switch for your brain's electrical activity. When you have a seizure, the electrical activity in your brain gets out of control. Didione helps to adjust this activity, making it easier to control and reducing the likelihood of seizures.","oneSentence":"Didione works by modulating the activity of neurons in the brain to control seizures.","technicalDetail":"Didione is a small molecule that acts as a GABA receptor agonist, increasing the inhibitory effects of GABA on neuronal activity, which helps to control seizures."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Ethadione","title":"Ethadione","extract":"Ethadione is an anticonvulsant medication in the oxazolidinedione family used mainly to treat seizures."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1072","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ethadione","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Ethadione","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T11:06:16.032706","biosimilars":[],"competitors":[{"drugName":"paramethadione","drugSlug":"paramethadione","fdaApproval":"1949-06-15","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"trimethadione","drugSlug":"trimethadione","fdaApproval":"1946-01-25","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"ethadione","indications":{"approved":[{"name":"Absence seizure","source":"DrugCentral","snomedId":79631006,"regulator":"FDA"},{"name":"Epilepsy","source":"DrugCentral","snomedId":84757009,"regulator":"FDA","usPrevalence":3400000,"globalPrevalence":50000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"paramethadione","brandName":"paramethadione","genericName":"paramethadione","approvalYear":"1949","relationship":"same-class"},{"drugId":"trimethadione","brandName":"trimethadione","genericName":"trimethadione","approvalYear":"1946","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"I0F8O700BB","CHEBI":"CHEBI:81296","UMLSCUI":"C0059690","ChEMBL_ID":"CHEMBL93047","DRUGBANK_ID":"DB13799","PUBCHEM_CID":"10630","MESH_SUPPLEMENTAL_RECORD_UI":"C007637"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":1,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"N03AC03","allCodes":["N03AC03"]},"biosimilarFilings":[],"recentPublications":[{"date":"1962 Oct","pmid":"13970793","title":"Renal histology during treatment with oxazolidine-diones (trimethadione, ethadione, and paramethadione).","journal":"Pediatrics"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Didione (ethadione) is a small molecule drug in the ethadione class, used to treat absence seizures and epilepsy. Its commercial status is unknown, but it is likely to be off-patent. As a medication, it is used to control seizures by modulating the activity of neurons in the brain. However, more information is needed to fully understand its pharmacological profile. Further research is required to determine its half-life, bioavailability, and other key characteristics.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}