{"id":"ethacizine","rwe":[{"pmid":"33442612","year":"2020","title":"A case of successful ablation of ventricular ectopic focus from the superior tricuspid annulus through the internal jugular vein: a case report.","finding":"","journal":"European heart journal. Case reports","studyType":"Clinical Study"},{"pmid":"32146624","year":"2020","title":"Peculiarities of Pharmacokinetics and Bioavailability of Some Cardiovascular Drugs under Conditions of Antiorthostatic Hypokinesia.","finding":"","journal":"Bulletin of experimental biology and medicine","studyType":"Clinical Study"},{"pmid":"21623727","year":"2011","title":"[Appearance of ECG signs of the Brugada syndrome during therapy with class 1C antiarrhythmic drug ethacizine].","finding":"","journal":"Kardiologiia","studyType":"Clinical Study"},{"pmid":"22629774","year":"2011","title":"[Abnormal liver function during therapy with amiodarone in patients with persistent atrial fibrillation].","finding":"","journal":"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology","studyType":"Clinical Study"},{"pmid":"18822782","year":"2008","title":"[Immunochemical properties of conjugated antigens from N-substituted phenothiazines and dibenzazepines with antiarrhythmic activity].","finding":"","journal":"Prikladnaia biokhimiia i mikrobiologiia","studyType":"Clinical Study"}],"tags":[{"label":"ethacizine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C01BC09","category":"atc"},{"label":"Active","category":"status"},{"label":"Supraventricular arrhythmia","category":"indication"},{"label":"Ventricular arrhythmia","category":"indication"},{"label":"Anti-Arrhythmia Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Psychotropic Drugs","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"etacizin","offLabel":[],"synonyms":["ethacizine","ethacizine hydrochloride","etacizin","ethacizin","ethacizine HCl"],"timeline":[],"approvals":[],"brandName":"Etacizin","ecosystem":[{"indication":"Supraventricular arrhythmia","otherDrugs":[],"globalPrevalence":null},{"indication":"Ventricular arrhythmia","otherDrugs":[{"name":"bretylium","slug":"bretylium","company":"Intl Medication"},{"name":"disopyramide","slug":"disopyramide","company":"Gd Searle Llc"},{"name":"lidocaine","slug":"lidocaine","company":"Fresenius Kabi Usa"},{"name":"mexiletine","slug":"mexiletine","company":""}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"ethacizine","explanation":"Think of the heart as a muscle that needs to beat in a regular rhythm. Potassium channels help control how fast the heart muscle contracts and relaxes. By blocking these channels, etacizin helps to slow down the heart rate and restore a normal rhythm.","oneSentence":"Etacizin works by blocking potassium channels in the heart, which helps to regulate abnormal heart rhythms.","technicalDetail":"Etacizin acts as a potassium channel blocker, specifically targeting the inward rectifier potassium channel (Kir2.x) and the voltage-gated potassium channel (Kv1.x), which are involved in the regulation of cardiac repolarization and action potential duration."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Ethacizine","title":"Ethacizine","extract":"Ethacizine (ethacyzine) is a class Ic antiarrhythmic agent, related to moracizine. It is used in Russia and some other CIS countries for the treatment of severe and/or refractory ventricular and supraventricular arrhythmias, especially those accompanied by organic heart disease. It is also indicated as a treatment of refractory tachycardia associated with Wolff–Parkinson–White syndrome."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4835","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ethacizine","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Ethacizine","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T11:15:16.552013","biosimilars":[],"competitors":[{"drugName":"propafenone","drugSlug":"propafenone","fdaApproval":"1989-11-27","genericCount":15,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"flecainide","drugSlug":"flecainide","fdaApproval":"1985-10-31","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"ethacizine","indications":{"approved":[{"name":"Supraventricular arrhythmia","source":"DrugCentral","snomedId":72654001,"regulator":"FDA"},{"name":"Ventricular arrhythmia","source":"DrugCentral","snomedId":44103008,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"propafenone","brandName":"propafenone","genericName":"propafenone","approvalYear":"1989","relationship":"same-class"},{"drugId":"flecainide","brandName":"flecainide","genericName":"flecainide","approvalYear":"1985","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"FE5SPV1Z6G","CHEBI":"CHEBI:134732","UMLSCUI":"C0059688","ChEMBL_ID":"CHEMBL1997663","KEGG_DRUG":"D10503","DRUGBANK_ID":"DB13645","PUBCHEM_CID":"107841","SECONDARY_CAS_RN":"57530-40-2","MESH_SUPPLEMENTAL_RECORD_UI":"C046818"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":79,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"C01BC09","allCodes":["C01BC09"]},"biosimilarFilings":[],"recentPublications":[{"date":"2020 Dec","pmid":"33442612","title":"A case of successful ablation of ventricular ectopic focus from the superior tricuspid annulus through the internal jugular vein: a case report.","journal":"European heart journal. Case reports"},{"date":"2020 Feb","pmid":"32146624","title":"Peculiarities of Pharmacokinetics and Bioavailability of Some Cardiovascular Drugs under Conditions of Antiorthostatic Hypokinesia.","journal":"Bulletin of experimental biology and medicine"},{"date":"2011","pmid":"21623727","title":"[Appearance of ECG signs of the Brugada syndrome during therapy with class 1C antiarrhythmic drug ethacizine].","journal":"Kardiologiia"},{"date":"2011","pmid":"22629774","title":"[Abnormal liver function during therapy with amiodarone in patients with persistent atrial fibrillation].","journal":"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology"},{"date":"2008 Sep-Oct","pmid":"18822782","title":"[Immunochemical properties of conjugated antigens from N-substituted phenothiazines and dibenzazepines with antiarrhythmic activity].","journal":"Prikladnaia biokhimiia i mikrobiologiia"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Etacizin is a small molecule class Ic antiarrhythmic agent. It is used to treat severe and/or refractory ventricular and supraventricular arrhythmias, particularly those accompanied by organic heart disease, and refractory tachycardia associated with Wolff–Parkinson–White syndrome.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}