{"id":"etanercept-liquid","safety":{"commonSideEffects":[{"rate":"37","effect":"Injection site reactions"},{"rate":"29","effect":"Upper respiratory tract infections"},{"rate":"12","effect":"Headache"},{"rate":"2-3","effect":"Serious infections"},{"rate":"0.1-0.5","effect":"Tuberculosis reactivation"}]},"_chembl":{"chemblId":"CHEMBL1201572","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Etanercept consists of the extracellular ligand-binding portion of the human TNF receptor II fused to the Fc region of human IgG1. It acts as a soluble TNF receptor that competitively inhibits TNF-α and TNF-β from binding to cell surface TNF receptors, thereby suppressing TNF-mediated inflammatory responses. This mechanism reduces inflammation and immune activation in autoimmune and inflammatory conditions.","oneSentence":"Etanercept is a TNF receptor fusion protein that binds and neutralizes tumor necrosis factor (TNF), a key inflammatory cytokine.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:11:39.899Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rheumatoid arthritis"},{"name":"Psoriatic arthritis"},{"name":"Ankylosing spondylitis"},{"name":"Polyarticular juvenile idiopathic arthritis"},{"name":"Plaque psoriasis"},{"name":"Crohn's disease"}]},"trialDetails":[{"nctId":"NCT04345458","phase":"PHASE3","title":"Safety and Efficacy Study of Prefilled Liquid Etanercept(Yisaipu) for Active Ankylosing Spondylitis","status":"COMPLETED","sponsor":"Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.","startDate":"2014-03-06","conditions":"Ankylosing Spondylitis","enrollment":640},{"nctId":"NCT01901185","phase":"PHASE3","title":"Study to Evaluate the Ability of Subjects With Rheumatoid Arthritis or Psoriatic Arthritis to Effectively Use a Reusable Autoinjector to Self-inject Etanercept","status":"COMPLETED","sponsor":"Amgen","startDate":"2013-06-11","conditions":"Rheumatoid Arthritis, Psoriatic Arthritis","enrollment":77},{"nctId":"NCT01731457","phase":"PHASE2","title":"Limitation of Ischemic Injury of a Kidney Stored in Machine Perfusion in Hypothermia - Evaluation of the Impact on Kidney Allograft Function","status":"COMPLETED","sponsor":"Medical University of Warsaw","startDate":"2011-04","conditions":"Transplanted Kidney Ischemia Reperfusion Injury","enrollment":94},{"nctId":"NCT01894412","phase":"PHASE1","title":"Safety and Pharmacokinetic Characteristics of HD203 Liquid in Healthy Male Volunteers","status":"COMPLETED","sponsor":"Hanwha Chemical","startDate":"2013-07","conditions":"Healthy","enrollment":48},{"nctId":"NCT02799498","phase":"PHASE1","title":"Compare Actions in Healthy Volunteer of 50 mg Etanercept Injection Using an Auto-injector Device and Manual Injection","status":"COMPLETED","sponsor":"Amgen","startDate":"2003-10","conditions":"Healthy Men and Women","enrollment":36},{"nctId":"NCT02588534","phase":"PHASE1","title":"Open-label Study Using 50 Mg Liquid Etanercept Subcutaneous Injection in the Thigh to Compare an Auto-injector Device and a Manual Injection in Healthy Subjects","status":"COMPLETED","sponsor":"Amgen","startDate":"2004-08","conditions":"Healthy Men and Women","enrollment":36},{"nctId":"NCT00110903","phase":"PHASE3","title":"Treatment for Subjects With Active Rheumatoid Arthritis (RA)","status":"COMPLETED","sponsor":"Amgen","startDate":"","conditions":"Rheumatoid Arthritis","enrollment":""},{"nctId":"NCT00249041","phase":"PHASE3","title":"Enbrel Liquid Immunogenicity Protocol","status":"COMPLETED","sponsor":"Amgen","startDate":"2005-10","conditions":"Rheumatoid Arthritis","enrollment":447}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":44,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Etanercept Liquid","genericName":"Etanercept Liquid","companyName":"Amgen","companyId":"amgen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Etanercept is a TNF receptor fusion protein that binds and neutralizes tumor necrosis factor (TNF), a key inflammatory cytokine. Used for Rheumatoid arthritis, Psoriatic arthritis, Ankylosing spondylitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}