{"id":"etamiphylline","rwe":[{"pmid":"41472739","year":"2025","title":"Ameliorative effects and mechanism of Panax notoginseng extract on ulcerative colitis mice based on a multi-omics strategy.","finding":"","journal":"Frontiers in immunology","studyType":"Clinical Study"},{"pmid":"20564606","year":"2010","title":"Identification of etamiphylline and metabolites in equine plasma and urine by accurate mass and liquid chromatography/tandem mass spectrometry.","finding":"","journal":"Drug testing and analysis","studyType":"Clinical Study"},{"pmid":"15620536","year":"2005","title":"N-deethylation and N-oxidation of etamiphylline: identification of etamiphylline-N-oxide in greyhound urine by high performance liquid chromatography-mass spectrometry.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"},{"pmid":"11874526","year":"2002","title":"The pharmacokinetics, metabolism and urinary detection time of etamiphylline in camels after intramuscular administration.","finding":"","journal":"Journal of veterinary pharmacology and therapeutics","studyType":"Clinical Study"},{"pmid":"2861956","year":"1985","title":"Ventilatory and cardiovascular responses of the unanaesthetized chicken, Gallus domesticus, to the respiratory stimulants etamiphylline and almitrine.","finding":"","journal":"Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology","studyType":"Clinical Study"}],"tags":[{"label":"etamiphylline","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"R03DA06","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Asthmatic Agents","category":"pharmacology"},{"label":"Bronchodilator Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Respiratory System Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"etamiphyllin","offLabel":[],"synonyms":["millophylline","etamiphylline camsilate","ethamicyclin","etamiphylline camsylate","etamiphylline camphorsulfonate","camphophylline","etamiphylline hydrochloride","etamiphylline HCl","etamiphyllin monohydrochloride","etamiphyllin","etamiphylline","etaminophylline"],"timeline":[],"approvals":[],"brandName":"Etamiphyllin","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"etamiphylline","explanation":"Imagine your airways are like a narrow tube that can constrict or relax. Phosphodiesterase enzymes help control how tight or loose the tube is. Etamiphylline blocks these enzymes, allowing the airway to relax and making it easier to breathe.","oneSentence":"Etamiphylline is thought to work by inhibiting phosphodiesterase enzymes, which play a role in regulating smooth muscle tone and airway constriction.","technicalDetail":"Etamiphylline is a non-selective phosphodiesterase inhibitor, which means it blocks multiple phosphodiesterase enzymes, including PDE3 and PDE4, leading to increased levels of cyclic AMP and cyclic GMP, resulting in smooth muscle relaxation and bronchodilation."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Etamiphylline","title":"Etamiphylline","extract":"Etamiphylline or etamiphyllin (INN) is a xanthine intended for use as an anti-asthma agent. It has shown poor to absent effects in human clinical trials."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3190","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=etamiphylline","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Etamiphylline","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T11:14:26.736631","biosimilars":[],"competitors":[{"drugName":"diprophylline","drugSlug":"diprophylline","fdaApproval":"1951-03-07","relationship":"same-class"},{"drugName":"choline theophyllinate","drugSlug":"choline-theophyllinate","fdaApproval":"1981-11-05","relationship":"same-class"},{"drugName":"theophylline","drugSlug":"theophylline","fdaApproval":"1940-04-19","genericCount":53,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"etamiphylline","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"diprophylline","brandName":"diprophylline","genericName":"diprophylline","approvalYear":"1951","relationship":"same-class"},{"drugId":"choline-theophyllinate","brandName":"choline theophyllinate","genericName":"choline theophyllinate","approvalYear":"1981","relationship":"same-class"},{"drugId":"theophylline","brandName":"theophylline","genericName":"theophylline","approvalYear":"1940","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"221A91BQ2S","CHEBI":"CHEBI:135157","INN_ID":"568","UMLSCUI":"C0059680","ChEMBL_ID":"CHEMBL2104264","KEGG_DRUG":"D07378","DRUGBANK_ID":"DB13592","PUBCHEM_CID":"28329","MESH_SUPPLEMENTAL_RECORD_UI":"C007635"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":11,"therapeuticAreas":["Respiratory"],"atcClassification":{"source":"DrugCentral","atcCode":"R03DA06","allCodes":["R03DA06","R03DB06"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025","pmid":"41472739","title":"Ameliorative effects and mechanism of Panax notoginseng extract on ulcerative colitis mice based on a multi-omics strategy.","journal":"Frontiers in immunology"},{"date":"2010 Jun","pmid":"20564606","title":"Identification of etamiphylline and metabolites in equine plasma and urine by accurate mass and liquid chromatography/tandem mass spectrometry.","journal":"Drug testing and analysis"},{"date":"2005 Jan 4","pmid":"15620536","title":"N-deethylation and N-oxidation of etamiphylline: identification of etamiphylline-N-oxide in greyhound urine by high performance liquid chromatography-mass spectrometry.","journal":"Journal of pharmaceutical and biomedical analysis"},{"date":"2002 Feb","pmid":"11874526","title":"The pharmacokinetics, metabolism and urinary detection time of etamiphylline in camels after intramuscular administration.","journal":"Journal of veterinary pharmacology and therapeutics"},{"date":"1985","pmid":"2861956","title":"Ventilatory and cardiovascular responses of the unanaesthetized chicken, Gallus domesticus, to the respiratory stimulants etamiphylline and almitrine.","journal":"Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Etamiphylline is a small molecule drug in the etamiphylline class, but its target and exact mechanism of action are unknown. It is not FDA-approved for any indications. The commercial status of etamiphylline is unclear, and it may be patented or off-patent. As a result, there is limited information available on its safety profile and pharmacokinetics. Further research is needed to fully understand etamiphylline's properties and potential uses.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}