{"id":"etafenone","rwe":[{"pmid":"10888308","year":"2000","title":"Propiverine-induced Parkinsonism: a case report and a pharmacokinetic/pharmacodynamic study in mice.","finding":"","journal":"Pharmaceutical research","studyType":"Clinical Study"},{"pmid":"6482088","year":"1984","title":"Effects of etafenone on myocardial energy metabolism as studied by an organ redoximeter and biochemical analyses.","finding":"","journal":"Japanese journal of pharmacology","studyType":"Clinical Study"},{"pmid":"6618341","year":"1983","title":"[Studies on the inhibitory effect of etafenone hydrochloride on platelet aggregation].","finding":"","journal":"Nihon yakurigaku zasshi. Folia pharmacologica Japonica","studyType":"Clinical Study"},{"pmid":"7191291","year":"1980","title":"Effect of calcium antagonist, etafenone hydrochloride, on the isolated guinea pig tracheal tissues.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"523840","year":"1979","title":"[Effect of calcium antagonist, etafenone hydrochloride, on the contractile responses in rabbit pulmonary artery and descending aorta strips (author's transl)].","finding":"","journal":"Kokyu to junkan. Respiration & circulation","studyType":"Clinical Study"}],"tags":[{"label":"etafenone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C01DX07","category":"atc"},{"label":"Active","category":"status"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Vasodilator Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"etafenon","offLabel":[],"synonyms":["etafenone","etafenon"],"timeline":[],"approvals":[],"brandName":"Etafenon","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"etafenone","explanation":"Imagine your heart is like a city with electrical signals that help it beat properly. Sometimes, these signals can get mixed up and cause problems. Etafenone helps to calm down the electrical activity in the heart by blocking the sodium channels, which can help to restore a normal heartbeat.","oneSentence":"Etafenone is thought to work by inhibiting the sodium channel, which can help to reduce abnormal electrical activity in the heart.","technicalDetail":"Etafenone is a class I antiarrhythmic agent that selectively blocks the sodium channel, which can help to reduce the frequency and severity of arrhythmias by stabilizing the cardiac membrane potential."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1069","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ETAFENONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:14:20.341313","biosimilars":[],"competitors":[{"drugName":"nesiritide","drugSlug":"nesiritide","fdaApproval":"2001-08-10","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"vericiguat","drugSlug":"vericiguat","fdaApproval":"2021-01-19","patentExpiry":"Nov 26, 2032","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"etafenone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"nesiritide","brandName":"nesiritide","genericName":"nesiritide","approvalYear":"2001","relationship":"same-class"},{"drugId":"vericiguat","brandName":"vericiguat","genericName":"vericiguat","approvalYear":"2021","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"0I14K589E7","CHEBI":"CHEBI:135389","INN_ID":"2451","UMLSCUI":"C0059677","ChEMBL_ID":"CHEMBL1736151","KEGG_DRUG":"D07922","DRUGBANK_ID":"DB13845","PUBCHEM_CID":"3275","MESH_SUPPLEMENTAL_RECORD_UI":"C001162"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":15,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"C01DX07","allCodes":["C01DX07"]},"biosimilarFilings":[],"recentPublications":[{"date":"2000 May","pmid":"10888308","title":"Propiverine-induced Parkinsonism: a case report and a pharmacokinetic/pharmacodynamic study in mice.","journal":"Pharmaceutical research"},{"date":"1984 Jul","pmid":"6482088","title":"Effects of etafenone on myocardial energy metabolism as studied by an organ redoximeter and biochemical analyses.","journal":"Japanese journal of pharmacology"},{"date":"1983 Jun","pmid":"6618341","title":"[Studies on the inhibitory effect of etafenone hydrochloride on platelet aggregation].","journal":"Nihon yakurigaku zasshi. 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