{"id":"etafedrine","rwe":[{"pmid":"4039586","year":"1985","title":"On the mechanism of bronchodilatation by etafedrine.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"326265","year":"1977","title":"[Double-blind long-term study on a combination of tetracycline, theophylline, doxylamine succinate, etafedrine, phenylephedrine and guaifenesine in chronic bronchitis (author's transl)].","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"793781","year":"1976","title":"Double-blind trial of a long-acting bronchodilator preparation (\"Nethaprin Dospan\") in bronchospastic disease.","finding":"","journal":"Current medical research and opinion","studyType":"Clinical Study"}],"tags":[{"label":"etafedrine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"menetryl","offLabel":[],"synonyms":["etafedrine hydrochloride","nethamine","etafedrine","ethylephedrine","menetryl","novedrine","etafedrine HCl"],"timeline":[],"approvals":[],"brandName":"Menetryl","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"etafedrine","explanation":"Imagine your brain is a city with different neighborhoods, and neurotransmitters are the messengers that help different neighborhoods communicate with each other. Menetryl helps increase the number of these messengers, allowing different neighborhoods to talk to each other more effectively. This can help improve various bodily functions, such as heart rate and blood pressure.","oneSentence":"Menetryl works by increasing the release of certain neurotransmitters in the body.","technicalDetail":"Etafedrine is a sympathomimetic agent that acts as a norepinephrine and dopamine reuptake inhibitor, increasing the concentration of these neurotransmitters in the synaptic cleft and enhancing their effects on the body."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3189","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=ETAFEDRINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ETAFEDRINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:05:13.267383","biosimilars":[],"competitors":[],"genericName":"etafedrine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT00857987","phase":"PHASE3","title":"Effectiveness and Safety of the of Guaifenesin, Doxylamine Succinate and Hydrochloride Etafedrine Syrup in Improvement of Symptoms Resulting From Acute Respiratory Infections.","status":"UNKNOWN","sponsor":"Azidus Brasil","startDate":"2010-04","conditions":["Upper Airway Infections"],"enrollment":174,"completionDate":"2011-12"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"001834","UNII":"2Y6VQU63E8","CHEBI":"CHEBI:134847","INN_ID":"1734","UMLSCUI":"C0059676","ChEMBL_ID":"CHEMBL2110926","KEGG_DRUG":"D04072","DRUGBANK_ID":"DB11587","PUBCHEM_CID":"10734","SNOMEDCT_US":"56389005","SECONDARY_CAS_RN":"530-35-8","MESH_SUPPLEMENTAL_RECORD_UI":"C007636"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":3,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"1985","pmid":"4039586","title":"On the mechanism of bronchodilatation by etafedrine.","journal":"Arzneimittel-Forschung"},{"date":"1977","pmid":"326265","title":"[Double-blind long-term study on a combination of tetracycline, theophylline, doxylamine succinate, etafedrine, phenylephedrine and guaifenesine in chronic bronchitis (author's transl)].","journal":"Arzneimittel-Forschung"},{"date":"1976","pmid":"793781","title":"Double-blind trial of a long-acting bronchodilator preparation (\"Nethaprin Dospan\") in bronchospastic disease.","journal":"Current medical research and opinion"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Menetryl, also known as etafedrine hydrochloride, is a small molecule medication.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}