{"id":"estrogen-probiotics","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Vaginal bleeding"}]},"_chembl":{"chemblId":"CHEMBL592868","moleculeType":"Small molecule","molecularWeight":"310.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Estrogen is administered alongside probiotic bacteria to enhance the gut microbiome's ability to metabolize and recirculate estrogen through the enterohepatic circulation. The estrobolome—the collection of gut bacteria genes involved in estrogen metabolism—is thought to be dysbiotic in certain conditions, and probiotics may restore this function while exogenous estrogen addresses hormonal deficiency. This combination approach targets both hormonal and microbiotic imbalances simultaneously.","oneSentence":"Estrogen supplementation combined with probiotics aims to restore healthy gut microbiota and improve estrogen metabolism through the estrobolome pathway.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:40:23.867Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Menopausal symptoms with dysbiosis"},{"name":"Estrogen deficiency with altered gut microbiota"}]},"trialDetails":[{"nctId":"NCT05573334","phase":"NA","title":"Vaginal Care System for Menopausal Women With Urinary Tract Infections","status":"COMPLETED","sponsor":"Vaginal Biome Science","startDate":"2023-07-10","conditions":"Urinary Tract Infections, Vaginal Flora Imbalance","enrollment":8},{"nctId":"NCT07201259","phase":"","title":"Exploring Gut Microbiome Differences in Female Cancer Patients With Varied Ovarian Function and Fertility Outcomes Following Immune Checkpoint Inhibitor Therapy","status":"NOT_YET_RECRUITING","sponsor":"West China Second University Hospital","startDate":"2025-10-10","conditions":"Malignant Tumors","enrollment":40},{"nctId":"NCT06963840","phase":"PHASE2","title":"Effect of Theronomic Ova-All Care on Biomarkers of Ovarian Health in Adult Female With Polycystic Ovarian Syndrome","status":"ACTIVE_NOT_RECRUITING","sponsor":"Wellizen Australia","startDate":"2025-05-09","conditions":"Polycystic Ovarian Syndrome (PCOS)","enrollment":16},{"nctId":"NCT05562518","phase":"PHASE4","title":"GRACE-trial: a Randomized Active-controlled Trial for vulvovaGinal atRophy in breAst Cancer Patients on Endocrine Therapy.","status":"RECRUITING","sponsor":"University Hospital, Ghent","startDate":"2022-03-21","conditions":"Vulvovaginal Atrophy, Breast Cancer","enrollment":160},{"nctId":"NCT03837015","phase":"PHASE1","title":"Estrogen, Probiotics and Vaginal Health to Prevent HIV Infection in ACB Women","status":"COMPLETED","sponsor":"McMaster University","startDate":"2019-11-04","conditions":"HIV-1-infection, Bacterial Vaginoses","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":254,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Estrogen + probiotics","genericName":"Estrogen + probiotics","companyName":"University Hospital, Ghent","companyId":"university-hospital-ghent","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Estrogen supplementation combined with probiotics aims to restore healthy gut microbiota and improve estrogen metabolism through the estrobolome pathway. Used for Menopausal symptoms with dysbiosis, Estrogen deficiency with altered gut microbiota.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}