{"id":"estriol-cream-0-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Vaginal irritation or burning"},{"rate":null,"effect":"Vaginal discharge"},{"rate":null,"effect":"Systemic estrogen absorption (minimal with topical application)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Estriol is a naturally occurring estrogen that acts as an estrogen receptor agonist in vaginal and urogenital tissues. When applied topically as a cream, it promotes vaginal epithelial maturation, increases vaginal blood flow, and restores normal vaginal flora and pH, thereby alleviating symptoms of atrophic vaginitis and urogenital atrophy associated with menopause or estrogen deficiency.","oneSentence":"Estriol is a weak estrogen that binds to estrogen receptors in vaginal and urogenital tissues to restore epithelial maturation and improve local tissue health.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:45:52.722Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Atrophic vaginitis and urogenital atrophy in postmenopausal women"},{"name":"Vaginal dryness and dyspareunia associated with menopause"}]},"trialDetails":[{"nctId":"NCT02712814","phase":"","title":"Subtypes of Provoked Vestibulodynia","status":"COMPLETED","sponsor":"Meir Medical Center","startDate":"2016-11-30","conditions":"Provoked Localized Vulvodynia","enrollment":113},{"nctId":"NCT03044652","phase":"PHASE4","title":"Investigation of Non-inferiority of Treatment of Vulvovaginal Dryness With WO2085 Moisturising Cream in Comparison to a Cream With 0.1% Estriol","status":"COMPLETED","sponsor":"Dr. August Wolff GmbH & Co. KG Arzneimittel","startDate":"2016-11","conditions":"Vulvovaginal Atrophy","enrollment":172},{"nctId":"NCT01319968","phase":"","title":"Postpartum Dyspareunia Resulting From Vaginal Atrophy","status":"COMPLETED","sponsor":"Meir Medical Center","startDate":"2011-03","conditions":"Vulvovaginal Atrophy, Dyspareunia Among Puerperal Women","enrollment":117}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Estriol Cream 0.1%","genericName":"Estriol Cream 0.1%","companyName":"Dr. August Wolff GmbH & Co. KG Arzneimittel","companyId":"dr-august-wolff-gmbh-co-kg-arzneimittel","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Estriol is a weak estrogen that binds to estrogen receptors in vaginal and urogenital tissues to restore epithelial maturation and improve local tissue health. Used for Atrophic vaginitis and urogenital atrophy in postmenopausal women, Vaginal dryness and dyspareunia associated with menopause.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}