{"id":"estriol-cream","safety":{"commonSideEffects":[{"rate":null,"effect":"Vaginal irritation or burning"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Vaginal bleeding or spotting"}]},"_chembl":null,"_dailymed":{"setId":"3ed85485-a441-4c05-e063-6394a90afef5","title":"MYEVER (ESTRIOL CREAM) CREAM [HUBEI REDRUI BUILDING MATERIALS CO., LTD.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Estriol is a weak estrogen that binds to estrogen receptors in vaginal and urogenital tissues, promoting epithelial proliferation, improving vaginal lubrication, and restoring tissue elasticity. The cream formulation allows for direct application to affected tissues, reducing systemic exposure compared to oral hormone replacement therapy while addressing menopausal symptoms such as vaginal atrophy and urogenital dysfunction.","oneSentence":"Estriol cream delivers the estrogen hormone estriol topically to provide localized or systemic estrogen replacement therapy.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:41:36.213Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vaginal atrophy and urogenital symptoms associated with menopause"},{"name":"Atrophic vaginitis"}]},"trialDetails":[{"nctId":"NCT06873971","phase":"NA","title":"Er:YAG Laser Combined With Vaginal Estriol for Genitourinary Syndrome of Menopause","status":"RECRUITING","sponsor":"University of Nove de Julho","startDate":"2025-12-10","conditions":"Genitourinary Syndrome of Menopause","enrollment":60},{"nctId":"NCT06391372","phase":"PHASE3","title":"Effect of Local Estriol Treatment Before Vaginal Repair Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"Hatice Tukenmez Kurnaz","startDate":"2024-04-01","conditions":"Pelvic Organ Prolapse, Pelvic Floor Disorders, Menopause","enrollment":36},{"nctId":"NCT03116022","phase":"PHASE1","title":"Use of Estriol at Distal Third of Vagina Improving Coital Pain in Post-menopause Women","status":"COMPLETED","sponsor":"University of Sao Paulo","startDate":"2017-06-01","conditions":"Dyspareunia, Menopause, Sexual Dysfunction","enrollment":125},{"nctId":"NCT06633705","phase":"PHASE4","title":"Changes in Neighbouring Microbiota in Genitourinary Syndrome","status":"COMPLETED","sponsor":"Koc University Hospital","startDate":"2023-11-10","conditions":"Genitourinary Syndrome of Menopause","enrollment":31},{"nctId":"NCT06425978","phase":"PHASE4","title":"Efficacy of the Use of Cellular Matrix/ A-CP-HA Kit","status":"RECRUITING","sponsor":"Fundación Santiago Dexeus Font","startDate":"2024-05-30","conditions":"Genitourinary Syndrome of Menopause","enrollment":192},{"nctId":"NCT04487392","phase":"PHASE2","title":"Photobiomodulation Effect on Vulvovaginal Atrophy in Postmenopausal Women.","status":"WITHDRAWN","sponsor":"University of Nove de Julho","startDate":"2020-12-15","conditions":"Vulvovaginal Atrophy","enrollment":""},{"nctId":"NCT05783479","phase":"NA","title":"Pharmacological Preparation of the Cervix for Hysteroscopy","status":"COMPLETED","sponsor":"Jagiellonian University","startDate":"2022-06-01","conditions":"Uterine Polyp, Uterine Bleeding, Endometrium; Senility","enrollment":96},{"nctId":"NCT03774407","phase":"PHASE2, PHASE3","title":"Vaginal Estriol in Multiple Sclerosis","status":"COMPLETED","sponsor":"Texas Tech University Health Sciences Center","startDate":"2019-06-20","conditions":"Multiple Sclerosis, Neurogenic Bladder","enrollment":21},{"nctId":"NCT02712814","phase":"","title":"Subtypes of Provoked Vestibulodynia","status":"COMPLETED","sponsor":"Meir Medical Center","startDate":"2016-11-30","conditions":"Provoked Localized Vulvodynia","enrollment":113},{"nctId":"NCT02892214","phase":"","title":"The Reciprocal Relations Between Psychosocial Characteristics and the Progression of Vestibulodynia","status":"COMPLETED","sponsor":"Meir Medical Center","startDate":"2016-11-30","conditions":"Localized Provoked Vulvodynia","enrollment":113},{"nctId":"NCT03032848","phase":"PHASE4","title":"Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients","status":"COMPLETED","sponsor":"Universidade Federal do Paraná","startDate":"2013-11-26","conditions":"Vaginitis Atropic, Pelvic Organ Prolapse, Endometrial Hyperplasia","enrollment":69},{"nctId":"NCT03044652","phase":"PHASE4","title":"Investigation of Non-inferiority of Treatment of Vulvovaginal Dryness With WO2085 Moisturising Cream in Comparison to a Cream With 0.1% Estriol","status":"COMPLETED","sponsor":"Dr. August Wolff GmbH & Co. KG Arzneimittel","startDate":"2016-11","conditions":"Vulvovaginal Atrophy","enrollment":172},{"nctId":"NCT02419729","phase":"PHASE3","title":"Evaluation of Fractional CO2 Laser Treatment Efficacy and Comparison to Vaginal Estrogen Therapy in Postmenopausal Women With Vulvovaginal Atrophy","status":"COMPLETED","sponsor":"Faculdade de Medicina do ABC","startDate":"2015-03","conditions":"Vulvovaginal Atrophy","enrollment":45},{"nctId":"NCT01319968","phase":"","title":"Postpartum Dyspareunia Resulting From Vaginal Atrophy","status":"COMPLETED","sponsor":"Meir Medical Center","startDate":"2011-03","conditions":"Vulvovaginal Atrophy, Dyspareunia Among Puerperal Women","enrollment":117},{"nctId":"NCT01557179","phase":"PHASE2","title":"Evaluation of the Efficacy and Safety of Hyaluronic Acid Vaginal Gel to Ease Vaginal Dryness","status":"COMPLETED","sponsor":"Lee's Pharmaceutical Limited","startDate":"2009-05","conditions":"The Primary Objective of This Study Was to Assess the Efficacy and Safety of Hyaluronic Acid Vaginal Gel in Treating Vaginal Dryness","enrollment":144},{"nctId":"NCT00908570","phase":"PHASE1","title":"Topical Estriol for Vaginal Health","status":"COMPLETED","sponsor":"Gynuity Health Projects","startDate":"2009-06","conditions":"Vaginal Health","enrollment":104}],"_emaApprovals":[],"_faersSignals":[{"count":4,"reaction":"RASH"},{"count":3,"reaction":"DEPRESSION"},{"count":3,"reaction":"FEELING ABNORMAL"},{"count":3,"reaction":"HEADACHE"},{"count":2,"reaction":"HYPERSENSITIVITY"},{"count":2,"reaction":"MALAISE"},{"count":2,"reaction":"MYALGIA"},{"count":2,"reaction":"PRODUCT SUBSTITUTION ISSUE"},{"count":1,"reaction":"ABDOMINAL PAIN"},{"count":1,"reaction":"ANXIETY"}],"_approvalHistory":[],"publicationCount":24,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"estriol cream","genericName":"estriol cream","companyName":"Hatice Tukenmez Kurnaz","companyId":"hatice-tukenmez-kurnaz","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Estriol cream is used to study various conditions, including vaginal health, genitourinary syndrome of menopause, and uterine health, in clinical trials. The exact mechanism of estriol cream is unknown, as per ChEMBL database.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}