{"id":"estring-vaginal-product","safety":{"commonSideEffects":[{"rate":null,"effect":"Vaginal irritation or discomfort"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Vaginal bleeding or spotting"},{"rate":null,"effect":"Breast tenderness"}]},"_chembl":{"chemblId":"CHEMBL2094006","moleculeType":"Small molecule","molecularWeight":"702.93"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The device is a flexible plastic ring impregnated with estradiol that provides sustained, localized hormone delivery to the vaginal epithelium. This restores estrogen levels in vaginal tissue, improving lubrication, elasticity, and reducing symptoms of atrophic vaginitis without significant systemic hormone absorption. The localized delivery minimizes systemic exposure compared to oral or transdermal hormone replacement therapy.","oneSentence":"Estring is a vaginal ring that releases estradiol directly into vaginal tissue to treat menopausal vaginal atrophy and related symptoms.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:40:24.703Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Atrophic vaginitis (vaginal atrophy) in postmenopausal women"},{"name":"Menopausal vaginal symptoms including dryness, irritation, and dyspareunia"}]},"trialDetails":[{"nctId":"NCT05457972","phase":"PHASE4","title":"Postpartum Vaginal Estrogen for Breastfeeding Patients","status":"RECRUITING","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2025-02-22","conditions":"Breastfeeding, Postpartum Sexual Dysfunction, Vaginal Atrophy","enrollment":100},{"nctId":"NCT07422506","phase":"NA","title":"A Real-World Study Comparing the Efficacy of Different Treatment Regimens for Early Missed Abortion","status":"RECRUITING","sponsor":"The Third Xiangya Hospital of Central South University","startDate":"2024-01-01","conditions":"Missed Abortion, Early Pregnancy Failure","enrollment":580},{"nctId":"NCT01984138","phase":"PHASE2","title":"REVIVE: Replens Versus Intra-Vaginal Estrogen for the Treatment of Vaginal Dryness on Aromatase Inhibitor Therapy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Polly A. 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