{"id":"estradiol-zesteem","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Vaginal bleeding"},{"rate":"10-20%","effect":"Breast tenderness"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Nausea"}]},"_chembl":null,"_fixedAt":"2026-03-30T16:00:54.024210","_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Estradiol binds to estrogen receptors in various tissues, including the uterus, breast, and bone, leading to changes in gene expression and cellular behavior. This results in a range of physiological effects, including the regulation of the menstrual cycle, the maintenance of bone density, and the modulation of lipid metabolism.","oneSentence":"Estradiol acts as an estrogen receptor agonist, mimicking the effects of the naturally occurring hormone estrogen in the body.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:11:39.131Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of menopausal symptoms, including hot flashes and vaginal dryness"},{"name":"Prevention of osteoporosis in postmenopausal women"}]},"_fixedFields":["pubmed(1)"],"trialDetails":[{"nctId":"NCT00984386","phase":"PHASE2","title":"Investigation of the Efficacy of Zesteem in Accelerating Early Wound Healing","status":"COMPLETED","sponsor":"Renovo","startDate":"2005-03","conditions":"Cicatrix, Wound-healing","enrollment":44},{"nctId":"NCT00426972","phase":"PHASE3","title":"Trial of Zesteem (Estradiol) in Healing of Split Thickness Skin Graft Donor Sites","status":"COMPLETED","sponsor":"Renovo","startDate":"2007-01","conditions":"Burn, Trauma, Varicose Ulcer","enrollment":148}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"recentPublications":[{"date":"2006","pmid":"30000355","title":"Estradiol.","journal":""}],"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"estradiol (Zesteem)","genericName":"estradiol (Zesteem)","companyName":"Renovo","companyId":"renovo","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Estradiol acts as an estrogen receptor agonist, mimicking the effects of the naturally occurring hormone estrogen in the body. Used for Treatment of menopausal symptoms, including hot flashes and vaginal dryness, Prevention of osteoporosis in postmenopausal women.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}