{"id":"estradiol-valerat","safety":{"commonSideEffects":[{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Vaginal bleeding"},{"rate":null,"effect":"Fluid retention"}]},"_chembl":null,"_dailymed":{"setId":"e8f94df9-0692-4462-a7f0-fe019a0a3f07","title":"DELESTROGEN (ESTRADIOL VALERATE) INJECTION [PAR HEALTH USA, LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Estradiol valerate is an esterified form of estradiol, the primary endogenous estrogen. It acts as a selective estrogen receptor agonist, binding to estrogen receptors α and β throughout the body. Upon absorption and metabolism, it releases free estradiol, which regulates gene transcription and physiological responses in estrogen-responsive tissues including the uterus, breast, bone, and cardiovascular system.","oneSentence":"Estradiol valerate is an estrogen receptor agonist that binds to and activates estrogen receptors to provide hormone replacement therapy.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:45:50.742Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hormone replacement therapy for menopausal symptoms"},{"name":"Estrogen deficiency states"}]},"trialDetails":[{"nctId":"NCT03854175","phase":"NA","title":"Effect of Vaginal Sildenafil Citrate on Endometrial Preparation and Outcome in Frozen Thawed Embryo Transfer Cycles","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2019-02","conditions":"Infertility","enrollment":80},{"nctId":"NCT01668446","phase":"PHASE4","title":"Effect of Adding Sildenafil to Protocol of Endometrial Preparation in Outcome of Frozen-thawed Embryo Transfer Cycles","status":"COMPLETED","sponsor":"farzaneh hojjat","startDate":"2009-09","conditions":"Endometrial Preparation, Frozen Embryo Transfer","enrollment":2}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"estradiol valerat","genericName":"estradiol valerat","companyName":"farzaneh hojjat","companyId":"farzaneh-hojjat","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Estradiol valerate is a small molecule that acts as an estrogen receptor alpha agonist. It is used in medical treatments for conditions such as infertility, endometrial preparation, and frozen embryo transfer, often in combination with other medications like sildenafil citrate.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}