{"id":"estradiol-transdermal-three-90-l-sprays","safety":{"commonSideEffects":[{"rate":null,"effect":"Breast tenderness or pain"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Application site reactions (erythema, irritation)"},{"rate":null,"effect":"Vaginal bleeding or spotting"},{"rate":null,"effect":"Fluid retention or bloating"}]},"_chembl":{"chemblId":"CHEMBL1511","moleculeType":"Small molecule","molecularWeight":"356.51"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Estradiol is a bioidentical estrogen that activates nuclear estrogen receptors in target tissues including the hypothalamus, pituitary, bone, cardiovascular system, and vaginal epithelium. The transdermal spray formulation delivers estradiol across the skin barrier, bypassing hepatic first-pass metabolism and providing sustained systemic hormone replacement. This restores estrogen-dependent physiological functions and alleviates symptoms associated with estrogen deficiency.","oneSentence":"Estradiol binds to estrogen receptors (ERα and ERβ) throughout the body to restore circulating estrogen levels in postmenopausal women.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:11:41.857Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vasomotor symptoms (hot flashes, night sweats) associated with menopause"},{"name":"Moderate to severe vulvovaginal atrophy associated with menopause"}]},"trialDetails":[{"nctId":"NCT01389102","phase":"PHASE3","title":"Estradiol Transdermal Spray in the Treatment of Vasomotor Symptoms","status":"COMPLETED","sponsor":"Lumara Health, Inc.","startDate":"2004-12","conditions":"Hot Flashes","enrollment":454}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Estradiol transdermal three 90 μL sprays","genericName":"Estradiol transdermal three 90 μL sprays","companyName":"Lumara Health, Inc.","companyId":"lumara-health-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Estradiol binds to estrogen receptors (ERα and ERβ) throughout the body to restore circulating estrogen levels in postmenopausal women. Used for Vasomotor symptoms (hot flashes, night sweats) associated with menopause, Moderate to severe vulvovaginal atrophy associated with menopause.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}