{"id":"estradiol-medroxy-progesterone-acetate","safety":{"commonSideEffects":[{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vaginal bleeding/spotting"},{"rate":null,"effect":"Bloating"},{"rate":null,"effect":"Mood changes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Estradiol is a bioidentical estrogen that binds to estrogen receptors (ERα and ERβ) to alleviate vasomotor symptoms, vaginal atrophy, and bone loss associated with menopause. Medroxyprogesterone acetate (MPA) is a synthetic progestin that protects the endometrium from unopposed estrogen stimulation, reducing the risk of endometrial hyperplasia and cancer in women with an intact uterus.","oneSentence":"This combination provides estrogen replacement and progestin supplementation to manage menopausal symptoms and prevent endometrial hyperplasia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:29:42.633Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Menopausal vasomotor symptoms (hot flashes, night sweats)"},{"name":"Vulvovaginal atrophy"},{"name":"Prevention of postmenopausal osteoporosis"}]},"trialDetails":[{"nctId":"NCT00294463","phase":"PHASE4","title":"Effects of Tibolone Treatment on the Endometrium","status":"COMPLETED","sponsor":"Erasmus Medical Center","startDate":"2003-02","conditions":"Postmenopause, Osteoporosis","enrollment":35}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":64,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Estradiol + Medroxy Progesterone Acetate","genericName":"Estradiol + Medroxy Progesterone Acetate","companyName":"Erasmus Medical Center","companyId":"erasmus-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination provides estrogen replacement and progestin supplementation to manage menopausal symptoms and prevent endometrial hyperplasia. Used for Menopausal vasomotor symptoms (hot flashes, night sweats), Vulvovaginal atrophy, Prevention of postmenopausal osteoporosis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}