{"id":"estradiol-e2-0-3mg","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Breast tenderness"},{"rate":"5-15","effect":"Headache"},{"rate":"5-10","effect":"Nausea"},{"rate":"5-15","effect":"Vaginal bleeding/spotting"},{"rate":"5-10","effect":"Fluid retention"},{"rate":"<1-2","effect":"Thromboembolic events"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Estradiol is the most potent endogenous estrogen and acts as a ligand for nuclear estrogen receptors, regulating gene transcription involved in reproductive, cardiovascular, bone, and central nervous system function. The 0.3 mg dose formulation is typically used for hormone replacement therapy or treatment of estrogen deficiency states. Bayer's phase 3 program likely evaluates efficacy and safety in menopausal symptoms or bone health indications.","oneSentence":"Estradiol is a naturally occurring estrogen that binds to estrogen receptors (ERα and ERβ) to modulate hormone-dependent physiological processes.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:11:38.097Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Menopausal vasomotor symptoms (hot flashes, night sweats)"},{"name":"Postmenopausal osteoporosis prevention"},{"name":"Estrogen deficiency states"}]},"trialDetails":[{"nctId":"NCT02969590","phase":"PHASE4","title":"Regulation of Cervical Mucus Secretion","status":"COMPLETED","sponsor":"Oregon Health and Science University","startDate":"2015-03-29","conditions":"Fertility, Contraception","enrollment":5},{"nctId":"NCT00446199","phase":"PHASE3","title":"Low-dose Hormone Therapy for Relief of Vasomotor Symptoms","status":"COMPLETED","sponsor":"Bayer","startDate":"2007-03","conditions":"Vasomotor Symptoms, Hot Flashes","enrollment":735}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":11,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Estradiol (E2 0.3mg)","genericName":"Estradiol (E2 0.3mg)","companyName":"Bayer","companyId":"bayer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Estradiol is a naturally occurring estrogen that binds to estrogen receptors (ERα and ERβ) to modulate hormone-dependent physiological processes. Used for Menopausal vasomotor symptoms (hot flashes, night sweats), Postmenopausal osteoporosis prevention, Estrogen deficiency states.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}