{"id":"estradiol-e2","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Breast tenderness"},{"rate":"5-15","effect":"Nausea"},{"rate":"5-10","effect":"Headache"},{"rate":"5-20","effect":"Vaginal bleeding/spotting"},{"rate":"5-10","effect":"Fluid retention"},{"rate":"0.5-2","effect":"Thromboembolic events"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Estradiol is the primary endogenous estrogen hormone that acts as a ligand for nuclear estrogen receptors, triggering downstream signaling cascades that regulate reproductive, cardiovascular, bone, and metabolic functions. It is used therapeutically in hormone replacement therapy and other endocrine conditions to restore or supplement estrogen levels.","oneSentence":"Estradiol binds to estrogen receptors (ERα and ERβ) in target tissues to modulate gene expression and produce estrogenic effects.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:11:42.516Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Menopausal vasomotor symptoms"},{"name":"Hormone replacement therapy"},{"name":"Hypogonadism"},{"name":"Transgender hormone therapy"}]},"trialDetails":[{"nctId":"NCT07358468","phase":"","title":"Impact Of FET Preparation Protocol On Endometrial Peristalsis: A Prospective Cohort Study","status":"RECRUITING","sponsor":"Mỹ Đức Hospital","startDate":"2026-02-22","conditions":"Infertility, Endometrial Peristalsis, Uterine Contraction","enrollment":356},{"nctId":"NCT07254429","phase":"PHASE2","title":"COMPASS - COpenhagen MenoPAuSe Study","status":"RECRUITING","sponsor":"Martin Blomberg Jensen","startDate":"2025-10-02","conditions":"Menopausal Osteoporosis, Bone Markers","enrollment":192},{"nctId":"NCT06307184","phase":"","title":"Assessing the Convenience of Natural Proliferative Phase Frozen Embryo Transfer","status":"RECRUITING","sponsor":"Instituto Valenciano de Infertilidade de Lisboa","startDate":"2024-02-23","conditions":"Frozen Embryo Transfer","enrollment":530},{"nctId":"NCT07398924","phase":"NA","title":"Vaginal Estradiol and Oral Guaifenesin in Clomiphene Ovulation Induction","status":"COMPLETED","sponsor":"Yuzuncu Yil University","startDate":"2022-01-06","conditions":"Female Infertility, Anovulatory Infertility, Unexplained Infertility","enrollment":90},{"nctId":"NCT07212712","phase":"NA","title":"The Role of Estrogen and Testosterone in Determining Brain Blood Flow and Metabolic Regulation in Humans","status":"NOT_YET_RECRUITING","sponsor":"University of British Columbia","startDate":"2026-04-01","conditions":"Cerebral Blood Flow, Cerebral Blood Flow Regulation, Sex Differences","enrollment":50},{"nctId":"NCT04756037","phase":"PHASE3","title":"Study of the Safety and Contraceptive Efficacy of Relugolix Combination Therapy in Women With Uterine Fibroids or Endometriosis Who Are at Risk for Pregnancy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Sumitomo Pharma Switzerland GmbH","startDate":"2021-03-18","conditions":"Contraception","enrollment":1020},{"nctId":"NCT01586000","phase":"PHASE2","title":"A Dose-finding Study to Evaluate the Effect of a Contraceptive Vaginal Ring, Releasing Nestorone® and Estradiol, on Cycle Control, Ovulation Inhibition, and Pharmacokinetics in Normal Cycling Women","status":"COMPLETED","sponsor":"Kimberly Myer","startDate":"2012-03","conditions":"Suppression of Ovulation","enrollment":197},{"nctId":"NCT07037082","phase":"","title":"Understanding Cycles to Improve Women's Health","status":"RECRUITING","sponsor":"University Hospital, Montpellier","startDate":"2025-09-01","conditions":"Woman of Reproductive Age, Socioeconomic Factors","enrollment":320},{"nctId":"NCT05264506","phase":"PHASE3","title":"Contraceptive Efficacy and Safety of NOMAC-E2 Combined Oral Contraceptive","status":"TERMINATED","sponsor":"Organon and Co","startDate":"2022-02-17","conditions":"Contraception","enrollment":3055},{"nctId":"NCT03432416","phase":"PHASE2","title":"Study of Efficacy, Cycle Control, and Safety of a NES-E2 Contraceptive Vaginal Ring","status":"COMPLETED","sponsor":"Premier Research","startDate":"2018-02-12","conditions":"Healthy Women, Female Contraception","enrollment":385},{"nctId":"NCT06191289","phase":"PHASE2","title":"Neurocognitive Mechanisms of Perimenstrual Estrogen Effects on Suicidality","status":"TERMINATED","sponsor":"University of Illinois at Chicago","startDate":"2024-03-16","conditions":"Suicide","enrollment":11},{"nctId":"NCT06879002","phase":"","title":"Comparing IVF/ICSI Cycle Outcomes of Post Ovulation Ovarian Stimulation Protocol With Elonva Without GnRH Antagonist to Follicular Phase Day 2 Stimulation Fixed Day 5 Antagonist Protocol","status":"NOT_YET_RECRUITING","sponsor":"ART Fertility Clinics LLC","startDate":"2025-12-30","conditions":"Stimulation in the Ovary, IVF Outcome","enrollment":252},{"nctId":"NCT07148921","phase":"","title":"Perception of Pain During Gender Affirming Hormone Therapy","status":"RECRUITING","sponsor":"Medical University of Vienna","startDate":"2024-12-01","conditions":"Transgender Persons, Pain Threshold, Perception of Pain","enrollment":40},{"nctId":"NCT07145281","phase":"NA","title":"Comparing the Effects of Sublingual Estradiol Treatment Versus Oral Estradiol With Cyproterone Acetate (CPA) Treatment on The Coagulation System in Transgender Women: A Prospective, Controlled Cohort Study","status":"COMPLETED","sponsor":"Tel-Aviv Sourasky Medical Center","startDate":"2022-11-10","conditions":"Gender Dysphoria, Adult, Blood Coagulation, Coagulation Factors","enrollment":30},{"nctId":"NCT03973229","phase":"EARLY_PHASE1","title":"Neuroendocrine Risk for PTSD in Women","status":"COMPLETED","sponsor":"Emory University","startDate":"2019-11-11","conditions":"PTSD, Trauma","enrollment":250},{"nctId":"NCT05862272","phase":"PHASE3","title":"A Phase 3B Study to Evaluate Bone Mineral Density With Long-Term Use of Relugolix Combination Tablet in Women With Uterine Fibroids or Endometriosis","status":"RECRUITING","sponsor":"Sumitomo Pharma Switzerland GmbH","startDate":"2023-08-14","conditions":"Uterine Fibroids, Endometriosis","enrollment":1000},{"nctId":"NCT06936930","phase":"","title":"Reproductive and Mental Health of Patients With Aplastic Anemia","status":"RECRUITING","sponsor":"Institute of Hematology & Blood Diseases Hospital, China","startDate":"2025-03-03","conditions":"Aplastic Anemia, Reproductive Health","enrollment":600},{"nctId":"NCT03271489","phase":"PHASE3","title":"Long-Term Safety Study of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women","status":"COMPLETED","sponsor":"AbbVie","startDate":"2017-09-13","conditions":"Heavy Menstrual Bleeding, Uterine Fibroids","enrollment":478},{"nctId":"NCT04202094","phase":"NA","title":"Fertility in Young Adults Who Did (Not) Store Testicular Tissue Before a Treatment Leading to Fertility Problems","status":"ENROLLING_BY_INVITATION","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2020-09-08","conditions":"Childhood Cancer, Hematological Disorders","enrollment":50},{"nctId":"NCT06715514","phase":"NA","title":"Menopausal Hormone Therapy, GLP-1 Agonists, and Glucose and Energy Homeostasis in Postmenopausal Women With Diabetes","status":"RECRUITING","sponsor":"Lia Bally","startDate":"2025-02-18","conditions":"Menopause, Type 2 Diabetes","enrollment":96},{"nctId":"NCT06280560","phase":"","title":"Impact of IVF Hormonal Therapy on Endometrial Receptivity and Endometrial Senescent Cell Pathological Accumulation","status":"RECRUITING","sponsor":"Fundación IVI","startDate":"2024-02-01","conditions":"Endometrial Receptivity","enrollment":60},{"nctId":"NCT05980091","phase":"PHASE1","title":"Optimal Timing of Euploid Day 6 Blastocyst Transfer in Frozen HRT Cycles, Day 6 or Day 7 of Progesterone Administration.","status":"RECRUITING","sponsor":"ART Fertility Clinics LLC","startDate":"2023-09-22","conditions":"Infertility, Fertility Issues, Infertility, Female","enrollment":316},{"nctId":"NCT05473273","phase":"","title":"Descriptive Analysis of Serum Immunological Markers During an Euploid Frozen Embryo Transfer in a Natural Cycle.","status":"RECRUITING","sponsor":"ART Fertility Clinics LLC","startDate":"2023-04-24","conditions":"Infertility, Female","enrollment":40},{"nctId":"NCT06806501","phase":"","title":"Muscle Mass, Quality, and the Menopause: Sex-specific Strategies to Mitigate Sarcopenia in Ageing Populations","status":"RECRUITING","sponsor":"University of Nottingham","startDate":"2024-07-29","conditions":"Healthy","enrollment":18},{"nctId":"NCT06773429","phase":"","title":"Estradiol and Brain Age","status":"COMPLETED","sponsor":"International Research Training Group 2804","startDate":"2018-08-01","conditions":"Estradiol (E2) Vs. Placebo (PLAC), Estradiol","enrollment":32},{"nctId":"NCT03976544","phase":"PHASE4","title":"Natural Cycle Versus Hormone Replacement Therapy Cycle for a Frozen-thawed Embryo Transfer in PGT Patients","status":"TERMINATED","sponsor":"CRG UZ Brussel","startDate":"2019-05-25","conditions":"Miscarriage, Frozen Embryo Transfer, Natural Cycle","enrollment":362},{"nctId":"NCT05969795","phase":"PHASE1","title":"Comparison of Live Birth Rate in Natural Cycle Single Euploid FET Versus Without Luteal Phase Support","status":"RECRUITING","sponsor":"ART Fertility Clinics LLC","startDate":"2023-09-05","conditions":"Pregnancy Related, Infertility, Female","enrollment":342},{"nctId":"NCT04280523","phase":"","title":"TranspulmonarY Estrogen Gradient and Estrogen Receptors (TYEGER) in PAH","status":"WITHDRAWN","sponsor":"Vanderbilt University Medical Center","startDate":"2021-01-05","conditions":"Pulmonary Arterial Hypertension","enrollment":""},{"nctId":"NCT03213457","phase":"PHASE3","title":"A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Participants With Moderate to Severe Endometriosis-Associated Pain","status":"COMPLETED","sponsor":"AbbVie","startDate":"2017-07-07","conditions":"Endometriosis","enrollment":681},{"nctId":"NCT04285892","phase":"NA","title":"Embryo Developmental Potential in a Novel 2-step IVM System","status":"COMPLETED","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2020-07-16","conditions":"In Vitro Maturation of Oocytes","enrollment":23},{"nctId":"NCT06654570","phase":"PHASE2","title":"Effects of Vaginal Estrogen on Serum Estradiol During Aromatase Inhibitor Therapy in Breast Cancer Patients with Vulvovaginal Atrophy: a Prospective Trial","status":"COMPLETED","sponsor":"Helsinki University Central Hospital","startDate":"2020-04-08","conditions":"Breast Cancer","enrollment":20},{"nctId":"NCT06644794","phase":"PHASE3","title":"Progesterone-modified Natural Cycle for FET","status":"NOT_YET_RECRUITING","sponsor":"Shandong University of Traditional Chinese Medicine","startDate":"2024-12-05","conditions":"Infertility, Female","enrollment":336},{"nctId":"NCT03047330","phase":"PHASE4","title":"Menopausal Sleep Fragmentation and Body Fat Gain","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2017-07-15","conditions":"Menopause","enrollment":41},{"nctId":"NCT00702520","phase":"","title":"Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial 38833 (P05783)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2006-04-01","conditions":"Pregnancy, Neonates","enrollment":15},{"nctId":"NCT05899010","phase":"PHASE3","title":"MIcronized PROgesterone in Frozen Embryo Transfer Cycles","status":"RECRUITING","sponsor":"Fundación Santiago Dexeus Font","startDate":"2023-07-05","conditions":"Infertility","enrollment":1020},{"nctId":"NCT03751124","phase":"PHASE3","title":"Study of Relugolix With Estradiol and Norethindrone Acetate in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids","status":"COMPLETED","sponsor":"Myovant Sciences GmbH","startDate":"2018-10-16","conditions":"Uterine Leiomyoma, Uterine Fibroids","enrollment":229},{"nctId":"NCT01656434","phase":"PHASE3","title":"Study of the Contraceptive Efficacy and Safety of a NOMAC-E2 Combined Oral Contraceptive (COC)(P06448)","status":"TERMINATED","sponsor":"Organon and Co","startDate":"2012-11-02","conditions":"Contraception","enrollment":3173},{"nctId":"NCT01709318","phase":"PHASE2","title":"A Dose-Finding Study to Evaluate Ovarian Function and Vaginal Bleeding in Next Generation Rings (P06109/MK-8175A/MK-8342B-012)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2012-12-12","conditions":"Contraception","enrollment":666},{"nctId":"NCT02668783","phase":"PHASE3","title":"Efficacy and Safety of Etonogestrel + 17β-Estradiol Vaginal Ring (MK-8342B) in Women With Primary Dysmenorrhea (With Optional Extension) (MK-8342B-059)","status":"TERMINATED","sponsor":"Organon and Co","startDate":"2016-02-11","conditions":"Moderate to Severe Primary Dysmenorrhea","enrollment":25},{"nctId":"NCT01670656","phase":"PHASE2","title":"A Study to Evaluate the Effect of Contraceptive Vaginal Rings on Primary Dysmenorrhea (P08257/MK-8175A/MK-8342B-057)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2013-01-21","conditions":"Dysmenorrhea","enrollment":439},{"nctId":"NCT02668822","phase":"PHASE3","title":"Efficacy and Safety of Etonogestrel + 17β-Estradiol Vaginal Ring (MK-8342B) in the Treatment of Women With Primary Dysmenorrhea (MK-8342B-060)","status":"TERMINATED","sponsor":"Organon and Co","startDate":"2016-02-09","conditions":"Dysmenorrhea","enrollment":18},{"nctId":"NCT02524288","phase":"PHASE3","title":"Efficacy and Safety of Etonogestrel + 17β-Estradiol Vaginal Ring in Women at Risk for Pregnancy (MK-8342B-061)","status":"TERMINATED","sponsor":"Organon and Co","startDate":"2015-08-31","conditions":"Contraception","enrollment":1941},{"nctId":"NCT02616146","phase":"PHASE3","title":"Efficacy and Safety of Etonogestrel + 17β-Estradiol Vaginal Ring and Levonorgestrel-Ethinyl Estradiol Combined Oral Contraceptive in Adult Women at Risk for Pregnancy (MK-8342B-062)","status":"TERMINATED","sponsor":"Organon and Co","startDate":"2015-12-01","conditions":"Contraception","enrollment":2016},{"nctId":"NCT03412890","phase":"PHASE3","title":"LIBERTY EXTENSION: Efficacy and Safety Extension Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids","status":"COMPLETED","sponsor":"Myovant Sciences GmbH","startDate":"2017-10-19","conditions":"Heavy Menstrual Bleeding, Uterine Fibroid","enrollment":477},{"nctId":"NCT04721522","phase":"","title":"The Impact of Endometrial Compaction on Assisted Reproductive Technology Outcome","status":"RECRUITING","sponsor":"Zagazig University","startDate":"2021-01-29","conditions":"Embryo Implantation, ART","enrollment":356},{"nctId":"NCT06181305","phase":"PHASE4","title":"Endometrial Preparation in Frozen Embryo Transfer Cycles","status":"UNKNOWN","sponsor":"Rahem Fertility Center","startDate":"2024-02-24","conditions":"IVF","enrollment":210},{"nctId":"NCT04671966","phase":"PHASE4","title":"Sex Differences in Myocardial Steatosis Induced Left Ventricular Dysfunction","status":"UNKNOWN","sponsor":"The University of Texas at Arlington","startDate":"2018-09-13","conditions":"Heart Diseases, Left Ventricular Dysfunction","enrollment":100},{"nctId":"NCT05168865","phase":"PHASE4","title":"Letrozole Versus Hormonal Preparation in Frozen Cycles of PCOS Patients.","status":"WITHDRAWN","sponsor":"Dubai Fertility Center","startDate":"2023-08-01","conditions":"Frozen Embryo Transfer, Polycystic Ovarian Disease, Letrozole","enrollment":""},{"nctId":"NCT05189145","phase":"NA","title":"Hormonal Monitoring and Progesterone Adjustment in Frozen Embryo Transfer Cycles","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2019-10-01","conditions":"Female Infertility","enrollment":600},{"nctId":"NCT06195202","phase":"","title":"Serum Estradiol (E2) Levels in Breast Cancer Patients During Endocrine Therapy by High Performance Liquid Chromatography-tandem Mass Spectrometry (LC-MS /MS)","status":"RECRUITING","sponsor":"Sun Yat-sen University","startDate":"2023-09-01","conditions":"Breast Cancer","enrollment":2000},{"nctId":"NCT05567731","phase":"NA","title":"Effect of GnRH Agonist Treatment Protocols on Ovarian Reserve","status":"COMPLETED","sponsor":"Tanta University","startDate":"2022-10-15","conditions":"Intracytoplasmic Sperm Injection, GnRH Agonist, Infertility","enrollment":30},{"nctId":"NCT04259996","phase":"","title":"Impact of Serum Progesterone in Modified Natural Cycles and Stimulated Cycles on Ongoing Pregnancy Rate","status":"COMPLETED","sponsor":"Instituto Valenciano de Infertilidad, IVI VALENCIA","startDate":"2020-02-19","conditions":"Infertility, Female","enrollment":488},{"nctId":"NCT05161338","phase":"NA","title":"Impact of Vaginal Microbiome on Vaginal Absorption of Exogenous Progesterone: a Pilot Study.","status":"COMPLETED","sponsor":"Instituto Valenciano de Infertilidad, IVI VALENCIA","startDate":"2022-02-15","conditions":"Infertility, Female","enrollment":100},{"nctId":"NCT05026502","phase":"","title":"A Study to Assess Patient-Reported Quality of Life and Effectiveness on Control of Bleeding in Adult Participants With Heavy Menstrual Bleeding Due to Uterine Fibroids Taking Oral Oriahnn Capsules","status":"TERMINATED","sponsor":"AbbVie","startDate":"2021-10-05","conditions":"Heavy Menstrual Bleeding, Uterine Fibroids","enrollment":23},{"nctId":"NCT03654274","phase":"PHASE3","title":"SPIRIT EXTENSION: Efficacy and Safety Extension Study of Relugolix in Women With Endometriosis-Associated Pain","status":"COMPLETED","sponsor":"Myovant Sciences GmbH","startDate":"2018-05-22","conditions":"Endometriosis","enrollment":802},{"nctId":"NCT05346159","phase":"","title":"Effects of Adrenal Androgens on Gender-typed Behavior in Girls With Turner Syndrome","status":"COMPLETED","sponsor":"Sohag University","startDate":"2022-05-01","conditions":"Turner Syndrome","enrollment":78},{"nctId":"NCT05716152","phase":"","title":"Hormonal Associations in Male Patients With Psoriasis Vulgaris","status":"UNKNOWN","sponsor":"Sohag University","startDate":"2023-02-01","conditions":"Psoriasis Vulgaris","enrollment":102},{"nctId":"NCT03236545","phase":"NA","title":"Menopause Effects on Vascular Function","status":"COMPLETED","sponsor":"University of Delaware","startDate":"2016-07-01","conditions":"Cardiovascular Risk Factor","enrollment":48},{"nctId":"NCT03498313","phase":"PHASE4","title":"Unique Effects of Perimenstrual Estradiol or Progesterone Supplementation on Perimenstrual Suicidality","status":"COMPLETED","sponsor":"University of Illinois at Chicago","startDate":"2018-07-27","conditions":"Suicidal Ideation","enrollment":60},{"nctId":"NCT04225221","phase":"PHASE2","title":"Neurobiology of Bulimia Nervosa","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2020-02-24","conditions":"Bulimia Nervosa","enrollment":10},{"nctId":"NCT01790282","phase":"NA","title":"Is Adding E2 to P4 Luteal Support In High Responder Long Gn-RH Agonist ICSI Cycles Detrimental to Outcome? RCT","status":"COMPLETED","sponsor":"Mansoura Integrated Fertility Center","startDate":"2013-03","conditions":"IVF, Infertility","enrollment":220},{"nctId":"NCT04507022","phase":"PHASE4","title":"The Outcome of Two Protocols Used to Prepare Endometrium for Frozen Embryo Transfer","status":"COMPLETED","sponsor":"Rahem Fertility Center","startDate":"2020-08-12","conditions":"Infertility, Infertility, Female, Infertility, Male","enrollment":112},{"nctId":"NCT03103087","phase":"PHASE3","title":"LIBERTY 2: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids","status":"COMPLETED","sponsor":"Myovant Sciences GmbH","startDate":"2017-06-14","conditions":"Heavy Menstrual Bleeding, Uterine Fibroid","enrollment":382},{"nctId":"NCT03049735","phase":"PHASE3","title":"LIBERTY 1: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids","status":"COMPLETED","sponsor":"Myovant Sciences GmbH","startDate":"2017-04-26","conditions":"Heavy Menstrual Bleeding, Uterine Fibroid","enrollment":388},{"nctId":"NCT01723579","phase":"PHASE3","title":"Efficacy and Safety of Oral NOMAC-E2 in Indian Women (P07057/MK-8175A-017)","status":"WITHDRAWN","sponsor":"Organon and Co","startDate":"2013-07","conditions":"Contraception","enrollment":""},{"nctId":"NCT01345786","phase":"PHASE1","title":"Bioequivalence of Nomegestrol Acetate (NOMAC) and Estradiol (E2) in Commercial Versus Phase 3 Pivotal Clinical Batches of NOMAC-E2 Tablets (P06328)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2009-11","conditions":"Healthy Postmenopausal Females","enrollment":158},{"nctId":"NCT00413062","phase":"PHASE3","title":"Efficacy and Safety Study of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing DRSP/EE (292002)(P05722)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2006-06","conditions":"Contraception","enrollment":2281},{"nctId":"NCT00511355","phase":"PHASE3","title":"Effects on Hemostasis, Lipids, Carbohydrate Metabolism, Adrenal & Thyroid Function of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing LNG-EE (292004)(COMPLETED)(P05764)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2006-10","conditions":"Contraception","enrollment":121},{"nctId":"NCT00511342","phase":"PHASE3","title":"Effects on Bone Mineral Density (BMD) of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing LNG/EE (292005)(P05765)(COMPLETED)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2006-09","conditions":"Contraception","enrollment":110},{"nctId":"NCT00511433","phase":"PHASE3","title":"Effects on Ovarian Function of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing DRSP/EE (292003)(COMPLETED)(P05723)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2006-10","conditions":"Contraception","enrollment":48},{"nctId":"NCT00511199","phase":"PHASE3","title":"Efficacy and Safety of the Combined Oral Contraceptive (COC) NOMAC-E2 Compared to a COC Containing DRSP/EE (292001)(COMPLETED)(P05724)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2006-05-01","conditions":"Contraception","enrollment":2152},{"nctId":"NCT00413764","phase":"PHASE3","title":"Efficacy of Tibolone Versus Transdermal E2/NETA on Sexual Function in Naturally Postmenopausal Women (P06089)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2004-03-23","conditions":"Sexual Dysfunction","enrollment":358},{"nctId":"NCT00711607","phase":"PHASE1","title":"A Trial to Assess the Pharmacokinetic Profile (e.g., Uptake, Distribution and Excretion of a Substance in the Body) of Nomegestrol Acetate (NOMAC), Estradiol (E2) and Estrone (E1) After Multiple and Single Dose Administration of the Combined Oral Contraception NOMAC-E2 (COMPLETED)(P05822)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2007-05-01","conditions":"Healthy","enrollment":25},{"nctId":"NCT00431093","phase":"PHASE4","title":"Trial to Compare the Effects of Tibolone (Livial®) and Continuous Combined Low-Dose Estradiol/Noresterone (Activelle®)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2002-11","conditions":"Menopause","enrollment":570},{"nctId":"NCT04769401","phase":"NA","title":"Effects of E2, P4 and LH Levels on the Day of Transfer and Endometrial Cavity Thickness on Implantation Success in Patients With Frozen-thawed Embryo Transfer Cycle","status":"COMPLETED","sponsor":"Bezmialem Vakif University","startDate":"2021-02-01","conditions":"Infertility, IVF, Progesterone","enrollment":238},{"nctId":"NCT03578172","phase":"NA","title":"HMG Stimulation Versus HRT for Endometrial Preparation Prior to Blastocyst Transfer in Moderate to Severe IUA Patients","status":"COMPLETED","sponsor":"Reproductive & Genetic Hospital of CITIC-Xiangya","startDate":"2018-07-18","conditions":"Infertility, Female, Intrauterine Adhesion","enrollment":186},{"nctId":"NCT03930706","phase":"NA","title":"SHorter Treatment of Replacement Therapy for Frozen Embryo Transfer (FET)","status":"COMPLETED","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2018-10-01","conditions":"Infertility","enrollment":150},{"nctId":"NCT04714554","phase":"PHASE1","title":"A Study of the Effects of Erythromycin on the Pharmacokinetics of Relugolix, Estradiol, and Norethindrone in Healthy Postmenopausal Women and on the Pharmacokinetics of Relugolix in Healthy Adult Men","status":"COMPLETED","sponsor":"Myovant Sciences GmbH","startDate":"2021-01-06","conditions":"Healthy","enrollment":43},{"nctId":"NCT01650168","phase":"","title":"Prospective Controlled Cohort Study on the Safety of a Monophasic Oral Contraceptive Containing Nomegestrol Acetate (2.5mg) and 17ß-estradiol (1.5mg)","status":"COMPLETED","sponsor":"Center for Epidemiology and Health Research, Germany","startDate":"2012-07","conditions":"Contraception","enrollment":101498},{"nctId":"NCT02925494","phase":"PHASE3","title":"An Extension Study to Evaluate the Efficacy and Safety of Elagolix in Premenopausal Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids","status":"COMPLETED","sponsor":"AbbVie","startDate":"2016-09-14","conditions":"Uterine Fibroids, Heavy Menstrual Bleeding","enrollment":433},{"nctId":"NCT02691494","phase":"PHASE3","title":"Efficacy and Safety of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women (Replicate Study)","status":"COMPLETED","sponsor":"AbbVie","startDate":"2016-02-03","conditions":"Uterine Fibroids, Heavy Menstrual Bleeding","enrollment":378},{"nctId":"NCT01441635","phase":"PHASE2","title":"Safety and Efficacy of Elagolix in Pre-Menopausal Women With Heavy Uterine Bleeding and Uterine Fibroids","status":"COMPLETED","sponsor":"AbbVie (prior sponsor, Abbott)","startDate":"2011-09-08","conditions":"Heavy Uterine Bleeding, Uterine Fibroids","enrollment":271},{"nctId":"NCT03204331","phase":"PHASE3","title":"SPIRIT 2: Efficacy and Safety Study of Relugolix in Women With Endometriosis-Associated Pain","status":"COMPLETED","sponsor":"Myovant Sciences GmbH","startDate":"2017-11-01","conditions":"Endometriosis Related Pain","enrollment":623},{"nctId":"NCT03204318","phase":"PHASE3","title":"SPIRIT 1: Efficacy and Safety Study of Relugolix in Women With Endometriosis-Associated Pain","status":"COMPLETED","sponsor":"Myovant Sciences GmbH","startDate":"2017-12-07","conditions":"Endometriosis Related Pain","enrollment":638},{"nctId":"NCT03112226","phase":"NA","title":"Effects of Ovarian Hormone Suppression on Vascular and Cognitive Function","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2018-02-07","conditions":"Cognitive Impairment, Estrogen Deficiency, Menopause","enrollment":19},{"nctId":"NCT01058252","phase":"","title":"Minimal Stimulation Protocol Using Aromek(Letrozole) and Follitrope(recFSH) Combined With INVOCell-Low Cost IVF","status":"UNKNOWN","sponsor":"Galaxy Pharma (Pvt) Limited","startDate":"2021-05","conditions":"Primary Infertility, Secondary Infertility, Low Responders","enrollment":30},{"nctId":"NCT04454749","phase":"","title":"Endometrial Compaction and Its Influence on Pregnancy Rate in Frozen Embryo Cycle Regimes","status":"TERMINATED","sponsor":"ART Fertility Clinics LLC","startDate":"2020-11-09","conditions":"Endometrial Disorder, Infertility, Female, IVF","enrollment":3},{"nctId":"NCT03954587","phase":"","title":"What is the Optimal Cycle Regimen for Frozen- Thawed Embryo Transfer Cycles","status":"TERMINATED","sponsor":"ART Fertility Clinics LLC","startDate":"2019-06-10","conditions":"Infertility, Female Infertility, Pregnancy Early","enrollment":4},{"nctId":"NCT04050592","phase":"PHASE4","title":"Discontinuation of Postmenopausal Hormone Therapy: Impact on the Cardiovascular System and Quality of Life","status":"UNKNOWN","sponsor":"Hanna Savolainen-Peltonen","startDate":"2020-02-19","conditions":"Menopause, Atherosclerosis, Cardiovascular Diseases","enrollment":150},{"nctId":"NCT03887728","phase":"","title":"Comparison of Blood Flow in the Arteriae Uterinae in Ovarian Stimulation Cycles","status":"COMPLETED","sponsor":"ART Fertility Clinics LLC","startDate":"2019-04-23","conditions":"Endometrial Receptivity","enrollment":124},{"nctId":"NCT02038335","phase":"","title":"HIV-Target Cell Response in Women Initiating Various Contraceptive Methods in High HIV-Incidence Areas: Zim CHIC","status":"COMPLETED","sponsor":"University of Pittsburgh","startDate":"2014-02","conditions":"Contraception, HIV, Immune Cells (Mucosal and Systemic)","enrollment":451},{"nctId":"NCT04009473","phase":"PHASE1, PHASE2","title":"Stem Cell Therapy and Growth Factor Ovarian in Vitro Activation","status":"UNKNOWN","sponsor":"Forever Young d.o.o.","startDate":"2019-06-01","conditions":"Menopause, Menopause Ovarian Failure, Ovarian Failure","enrollment":100},{"nctId":"NCT01817530","phase":"PHASE2","title":"Safety and Efficacy in Premenopausal Women With Heavy Menstrual Bleeding (HMB) Associated With Uterine Fibroids (UF)","status":"COMPLETED","sponsor":"AbbVie","startDate":"2013-04-08","conditions":"Heavy Uterine Bleeding, Uterine Fibroids","enrollment":571},{"nctId":"NCT04114500","phase":"","title":"The Association Between Serum E2 and P on the Day of FET and the Pregnancy Outcome","status":"COMPLETED","sponsor":"Al Baraka Fertility Hospital","startDate":"2018-04-03","conditions":"Frozen Embryo Transfer","enrollment":402},{"nctId":"NCT02654054","phase":"PHASE3","title":"Efficacy and Safety of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women","status":"COMPLETED","sponsor":"AbbVie","startDate":"2015-12-22","conditions":"Uterine Fibroids, Heavy Menstrual Bleeding","enrollment":413},{"nctId":"NCT04418908","phase":"NA","title":"Estrogen, Diabetes, and Endothelial Function","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2010-11-24","conditions":"Type 1 Diabetes","enrollment":40},{"nctId":"NCT03373149","phase":"PHASE2","title":"Growth Hormone Co-treatment Within a GnRH Antagonist Protocol in Patients With Poor Ovarian Response","status":"UNKNOWN","sponsor":"Riyadh Fertility and Reproductive Health center","startDate":"2017-11-29","conditions":"Infertility, Female","enrollment":228},{"nctId":"NCT03343067","phase":"PHASE3","title":"A Study to Evaluate Safety and Efficacy of Elagolix in Participants With Endometriosis With Associated Moderate to Severe Pain","status":"TERMINATED","sponsor":"AbbVie","startDate":"2017-12-27","conditions":"Endometriosis","enrollment":11},{"nctId":"NCT02969590","phase":"PHASE4","title":"Regulation of Cervical Mucus Secretion","status":"COMPLETED","sponsor":"Oregon Health and Science University","startDate":"2015-03-29","conditions":"Fertility, Contraception","enrollment":5},{"nctId":"NCT01940653","phase":"PHASE4","title":"Optimal Length of Progesterone Supplementation Before the Transfer of Cryopreserved (Frozen)-Thawed Day 3 Embryos in an Artificial Cycle With Exogenous Estrogen and Progesterone","status":"COMPLETED","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2012-11","conditions":"Progesterone Supplementation","enrollment":300}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":16106,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Estreva","E2","Estrofem","Vaginal Estradiol"],"phase":"phase_3","status":"active","brandName":"Estradiol (E2)","genericName":"Estradiol (E2)","companyName":"Martin Blomberg Jensen","companyId":"martin-blomberg-jensen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Estradiol binds to estrogen receptors (ERα and ERβ) in target tissues to modulate gene expression and produce estrogenic effects. Used for Menopausal vasomotor symptoms, Hormone replacement therapy, Hypogonadism.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}