{"id":"estracomb-tts","safety":{"commonSideEffects":[{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Skin irritation at patch site"},{"rate":null,"effect":"Vaginal bleeding/spotting"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The patch delivers estradiol (a bioidentical estrogen) and norethisterone acetate (a synthetic progestin) through the skin, bypassing first-pass hepatic metabolism. This combination provides systemic hormone replacement to alleviate menopausal symptoms and protect the endometrium from unopposed estrogen stimulation.","oneSentence":"Estracomb TTS is a transdermal hormone replacement therapy combining estradiol and norethisterone acetate to replace declining estrogen and progestin levels in postmenopausal women.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:29:42.644Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Menopausal vasomotor symptoms (hot flushes, night sweats)"},{"name":"Postmenopausal hormone replacement therapy"}]},"trialDetails":[{"nctId":"NCT03921736","phase":"PHASE4","title":"Reversal of an Unfavorable Effect of Hydrochlorothiazide Compared to Angiotensin Converting Enzyme Inhibitor on Serum Uric Acid and Oxypurines Levels by Estrogen-progestin Therapy in Hypertensive Postmenopausal Women.","status":"COMPLETED","sponsor":"Anna Posadzy-Małaczyńska","startDate":"2000-01-10","conditions":"Hypertension, Hyperuricemia, Menopause","enrollment":180}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"DEAFNESS"},{"count":1,"reaction":"DEAFNESS UNILATERAL"},{"count":1,"reaction":"EYE OPERATION"},{"count":1,"reaction":"GLUCOSE TOLERANCE IMPAIRED"},{"count":1,"reaction":"HYPERTENSION"},{"count":1,"reaction":"LIPIDS INCREASED"},{"count":1,"reaction":"WEIGHT INCREASED"}],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Estracomb TTS","genericName":"Estracomb TTS","companyName":"Anna Posadzy-Małaczyńska","companyId":"anna-posadzy-ma-aczy-ska","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Estracomb TTS is a transdermal hormone replacement therapy combining estradiol and norethisterone acetate to replace declining estrogen and progestin levels in postmenopausal women. Used for Menopausal vasomotor symptoms (hot flushes, night sweats), Postmenopausal hormone replacement therapy.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}