{"id":"essences-and-essential-oils","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation or sensitization"},{"rate":null,"effect":"Allergic reactions"},{"rate":null,"effect":"Photosensitivity (certain oils)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Essential oils contain concentrated plant-derived volatile compounds that may act through multiple pathways including olfactory receptor stimulation, transdermal absorption, and direct antimicrobial or anti-inflammatory effects. The exact mechanisms vary by oil composition and application route, but commonly involve modulation of the nervous system, local tissue effects, and aromatic-mediated responses.","oneSentence":"Essential oils and essences exert therapeutic effects through volatile aromatic compounds that interact with olfactory and dermal systems to produce physiological and psychological benefits.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:29:40.786Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Symptomatic relief and wellness support (aromatherapy and topical applications)"}]},"trialDetails":[{"nctId":"NCT05583240","phase":"PHASE4","title":"Influence of Olfaction Essential Oils on the Consumption of Benzodiazepine Receptor Agonists & Z-Drugs (BZRAs) Prescribed as \" if Needed \" in Psychiatric Outpatients (HECBA-PSY).","status":"UNKNOWN","sponsor":"Etablissement Public de Santé Barthélemy Durand","startDate":"2021-04-19","conditions":"Psychiatric Disorder, Benzodiazepine Withdrawal","enrollment":50},{"nctId":"NCT04764981","phase":"NA","title":"Olfactory Training for Olfactory Dysfunction After Coronavirus Disease - 19 (COVID-19)","status":"UNKNOWN","sponsor":"Universidade do Estado do Pará","startDate":"2021-05","conditions":"Covid19, SARS-CoV Infection, Olfactory Disorder","enrollment":350}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Essences and Essential Oils","genericName":"Essences and Essential Oils","companyName":"Etablissement Public de Santé Barthélemy Durand","companyId":"etablissement-public-de-sant-barth-lemy-durand","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Essential oils and essences exert therapeutic effects through volatile aromatic compounds that interact with olfactory and dermal systems to produce physiological and psychological benefits. Used for Symptomatic relief and wellness support (aromatherapy and topical applications).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}