{"id":"esomeprazole-ppi","safety":{"commonSideEffects":[{"rate":"12-15%","effect":"Headache"},{"rate":"10-15%","effect":"Diarrhea"},{"rate":"7-10%","effect":"Nausea"},{"rate":"5-8%","effect":"Abdominal pain"},{"rate":"3-5%","effect":"Constipation"},{"rate":"3-5%","effect":"Flatulence"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Esomeprazole is the active S-enantiomer of omeprazole that binds to and inactivates the H+/K+-ATPase enzyme (proton pump) on the secretory surface of gastric parietal cells. This blocks the final step of gastric acid production, significantly reducing intragastric acidity. It is used to treat acid-related disorders by maintaining elevated gastric pH.","oneSentence":"Esomeprazole irreversibly inhibits the proton pump in gastric parietal cells, reducing gastric acid secretion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:45:48.267Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastroesophageal reflux disease (GERD)"},{"name":"Peptic ulcer disease"},{"name":"Zollinger-Ellison syndrome"},{"name":"Prevention of NSAID-induced ulcers"},{"name":"Helicobacter pylori eradication (as part of combination therapy)"}]},"trialDetails":[{"nctId":"NCT07312370","phase":"PHASE4","title":"Esomeprazole Plus Sucralfate for Post-ESD Ulcer Healing","status":"NOT_YET_RECRUITING","sponsor":"LanZhou University","startDate":"2026-04-20","conditions":"Early Gastric Cancer, Gastric Dysplasia, Gastric Neoplasms","enrollment":120},{"nctId":"NCT05582174","phase":"PHASE4","title":"PPI Infusion Versus Oral Acid Pump Inhibitors for Bleeding Peptic Ulcers","status":"RECRUITING","sponsor":"Chinese University of Hong Kong","startDate":"2023-05-18","conditions":"Upper GI Bleeding, Proton Pump Inhibitors","enrollment":594},{"nctId":"NCT06953986","phase":"NA","title":"A Randomized, Three-Arm Study Comparing Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg for the Healing of LA Grade B or Higher Reflux Esophagitis at 8 Weeks","status":"RECRUITING","sponsor":"Asian Institute of Gastroenterology, India","startDate":"2025-12-20","conditions":"GERD","enrollment":414},{"nctId":"NCT06943794","phase":"NA","title":"Eradication of Helicobacter Pylori Subtypes at High Gastric Cancer Risk: a Cluster-randomized Controlled Trial","status":"NOT_YET_RECRUITING","sponsor":"Fudan University","startDate":"2026-03-30","conditions":"Gastric (Stomach) Cancer","enrollment":4824},{"nctId":"NCT07326904","phase":"PHASE3","title":"Study Comparing Fexuprazan and Esomeprazole in Patients With Gastroesophageal Reflux Disease","status":"COMPLETED","sponsor":"Indonesia University","startDate":"2024-09-23","conditions":"Gastro Oesophageal Reflux Disease","enrollment":145},{"nctId":"NCT07268820","phase":"PHASE4","title":"Heartburn, Gastroesophageal Reflux Disease","status":"RECRUITING","sponsor":"Incheon St.Mary's Hospital","startDate":"2025-07-07","conditions":"GERD","enrollment":160},{"nctId":"NCT07260006","phase":"NA","title":"Treatment Efficacy of Regimens With and Without Bismuth in Children With Helicobacter Pylori-Associated Peptic Ulcer Disease","status":"RECRUITING","sponsor":"Can Tho University of Medicine and Pharmacy","startDate":"2024-10-01","conditions":"Helicobacter Pylori Infection, Peptic Ulcer","enrollment":80},{"nctId":"NCT06991179","phase":"PHASE1","title":"A Study of Food Effect and Esomeprazole on LY4064809 in Healthy Adult Participants","status":"COMPLETED","sponsor":"Scorpion Therapeutics, a wholly owned subsidiary of Eli Lilly and Company","startDate":"2025-05-20","conditions":"Healthy","enrollment":36},{"nctId":"NCT07036627","phase":"","title":"Intestinal Microbiota After PPI Treatment","status":"NOT_YET_RECRUITING","sponsor":"University of Bari","startDate":"2025-07-06","conditions":"Proton Pump Inhibitors, Human Gastrointestinal Tract, Gastroesophageal Reflux Disease","enrollment":100},{"nctId":"NCT06955520","phase":"NA","title":"Vonaprazan Versus Esomeprazole for Healing of LA Grade B or Higher Esophagitis After POEM","status":"RECRUITING","sponsor":"Asian Institute of Gastroenterology, India","startDate":"2025-04-30","conditions":"GERD","enrollment":300},{"nctId":"NCT06966856","phase":"PHASE3","title":"This Randomized, Clinical Trial Evaluates the Efficacy of Oral Versus Sublingual Vitamin B12 Supplementation in Correcting Early-onset Vitamin B12 Deficiency in Adult Patients Using Proton Pump Inhibitors (PPIs). 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