{"id":"esomeprazole-nexium","safety":{"commonSideEffects":[{"rate":"11-13%","effect":"Headache"},{"rate":"9-15%","effect":"Diarrhea"},{"rate":"7-9%","effect":"Nausea"},{"rate":"5-8%","effect":"Abdominal pain"},{"rate":"3-5%","effect":"Constipation"},{"rate":"3-4%","effect":"Flatulence"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Esomeprazole is the active S-enantiomer of omeprazole that binds to and inactivates the H+/K+-ATPase enzyme (proton pump) on the secretory surface of gastric parietal cells. This blocks the final step of gastric acid production, significantly reducing intragastric acidity. It is used to treat acid-related disorders by maintaining elevated gastric pH.","oneSentence":"Esomeprazole irreversibly inhibits the proton pump in gastric parietal cells, reducing gastric acid secretion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:29:39.649Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastroesophageal reflux disease (GERD)"},{"name":"Peptic ulcer disease"},{"name":"Zollinger-Ellison syndrome"},{"name":"Prevention of NSAID-induced ulcers"},{"name":"Helicobacter pylori eradication (as part of combination therapy)"}]},"trialDetails":[{"nctId":"NCT07312370","phase":"PHASE4","title":"Esomeprazole Plus Sucralfate for Post-ESD Ulcer Healing","status":"NOT_YET_RECRUITING","sponsor":"LanZhou University","startDate":"2026-04-20","conditions":"Early Gastric Cancer, Gastric Dysplasia, Gastric Neoplasms","enrollment":120},{"nctId":"NCT05582174","phase":"PHASE4","title":"PPI Infusion Versus Oral Acid Pump Inhibitors for Bleeding Peptic Ulcers","status":"RECRUITING","sponsor":"Chinese University of Hong Kong","startDate":"2023-05-18","conditions":"Upper GI Bleeding, Proton Pump Inhibitors","enrollment":594},{"nctId":"NCT07294846","phase":"PHASE1","title":"Drug Interaction Study on Linaprazan Glurate Capsules","status":"COMPLETED","sponsor":"Jiangsu Sinorda Biomedicine Co., Ltd","startDate":"2025-09-08","conditions":"Healthy Volunteers, Patients","enrollment":56},{"nctId":"NCT07260006","phase":"NA","title":"Treatment Efficacy of Regimens With and Without Bismuth in Children With Helicobacter Pylori-Associated Peptic Ulcer Disease","status":"RECRUITING","sponsor":"Can Tho University of Medicine and Pharmacy","startDate":"2024-10-01","conditions":"Helicobacter Pylori Infection, Peptic Ulcer","enrollment":80},{"nctId":"NCT03866668","phase":"PHASE2","title":"A Study of Esomeprazole in Children With Autism","status":"RECRUITING","sponsor":"Stanford University","startDate":"2019-05-29","conditions":"Autism, Autism Spectrum Disorder","enrollment":25},{"nctId":"NCT05267613","phase":"PHASE3","title":"Endoscopic Evidence of Maintenance of Healing With Oral NEXIUM in Patients 1 to 11 Years Old With Erosive Esophagitis.","status":"RECRUITING","sponsor":"AstraZeneca","startDate":"2022-07-01","conditions":"Erosive Esophagitis","enrollment":50},{"nctId":"NCT05742568","phase":"PHASE4","title":"Effects of High-dose Dual Therapy and Bismuth Quadruple Therapy for Helicobacter Pylori Eradication on Intestinal Microecology","status":"COMPLETED","sponsor":"Xijing Hospital of Digestive Diseases","startDate":"2022-12-01","conditions":"Gastritis, Dyspepsia, Helicobacter Pylori Infection","enrollment":124},{"nctId":"NCT05320796","phase":"PHASE4","title":"The Bioavailability and Effect on Pouch pH of Esomeprazole After Gastric Bypass","status":"RECRUITING","sponsor":"Prof Urs Zingg","startDate":"2023-11-01","conditions":"Obesity, Gastric Reflux, Ulcer, Gastric","enrollment":50},{"nctId":"NCT00357682","phase":"PHASE3","title":"A Phase III, Randomized, Study of Aspirin and Esomeprazole Chemoprevention in Barrett's Metaplasia","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2005-03-10","conditions":"Esophageal Cancer, Precancerous Condition","enrollment":2557},{"nctId":"NCT06903585","phase":"PHASE2","title":"Non Steroidal Anti-inflammatory Drugs in the Prevention of Bone Pain Flares After Palliative Radiotherapy","status":"NOT_YET_RECRUITING","sponsor":"American University of Beirut Medical Center","startDate":"2025-04","conditions":"Bone Pain Flare, Bone Metastasis","enrollment":385},{"nctId":"NCT01471925","phase":"PHASE3","title":"Study Comparing Esomeprazole Associated With Sodium Bicarbonate From Eurofarma and Esomeprazole in Treatment of Gastroesophageal Reflux Disease ESOBIC","status":"WITHDRAWN","sponsor":"Eurofarma Laboratorios S.A.","startDate":"","conditions":"Gastroesophageal Reflux Disease","enrollment":""},{"nctId":"NCT06850480","phase":"PHASE3","title":"A Phase III Clinical Trial for Efficacy and Safety Evaluation of JP-1366 Tablets on Reflux Esophagitis","status":"RECRUITING","sponsor":"Livzon Pharmaceutical Group Inc.","startDate":"2024-12-05","conditions":"Reflux Esophagitis (RE)","enrollment":356},{"nctId":"NCT05287633","phase":"PHASE1, PHASE2","title":"Proton Pump Inhibitors Effects on Dyspepsia During Ramadan Fasting","status":"COMPLETED","sponsor":"University of Monastir","startDate":"2020-01-20","conditions":"Dyspepsia","enrollment":500},{"nctId":"NCT06823791","phase":"PHASE1, PHASE2","title":"Furazolidone Quadruple Regimen Eradicate H. 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