{"id":"esomeprazole-magnesium-enteric-coated-tablets","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Headache"},{"rate":"5-10","effect":"Diarrhea"},{"rate":"5-10","effect":"Nausea"},{"rate":"3-8","effect":"Abdominal pain"},{"rate":"3-5","effect":"Constipation"}]},"_chembl":{"chemblId":"CHEMBL5314366","moleculeType":"Small molecule","molecularWeight":"769.20"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Esomeprazole is the active S-enantiomer of omeprazole and works by inhibiting the final step of gastric acid production. The enteric coating allows the tablet to bypass the acidic stomach environment and dissolve in the small intestine, where the drug is absorbed and then transported to parietal cells to exert its acid-suppressing effect. This sustained acid suppression promotes healing of acid-related lesions and provides symptom relief.","oneSentence":"Esomeprazole magnesium is a proton pump inhibitor that suppresses gastric acid secretion by irreversibly blocking the H+/K+-ATPase enzyme in gastric parietal cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:11:33.973Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastroesophageal reflux disease (GERD)"},{"name":"Peptic ulcer disease"},{"name":"Zollinger-Ellison syndrome"},{"name":"Prevention of NSAID-induced ulcers"}]},"trialDetails":[{"nctId":"NCT07294846","phase":"PHASE1","title":"Drug Interaction Study on Linaprazan Glurate Capsules","status":"COMPLETED","sponsor":"Jiangsu Sinorda Biomedicine Co., Ltd","startDate":"2025-09-08","conditions":"Healthy Volunteers, Patients","enrollment":56},{"nctId":"NCT05577468","phase":"PHASE3","title":"Efficacy and Safety of Tegoprazan Versus Esomeprazole-containing Bismuth Quadruple Therapy for Eradication of Helicobacter Pylori","status":"COMPLETED","sponsor":"Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.","startDate":"2022-10-30","conditions":"Helicobacter Pylori Infection","enrollment":561},{"nctId":"NCT04696783","phase":"PHASE3","title":"The Effect of PPI in Preventing Gastroesophageal Reflux Disease of Seafarers","status":"UNKNOWN","sponsor":"Fifth Affiliated Hospital, Sun Yat-Sen University","startDate":"2021-07","conditions":"Gastroesophageal Reflux Disease","enrollment":92},{"nctId":"NCT04034641","phase":"PHASE4","title":"Effect of Probiotics on Helicobacter Pylori Eradication","status":"UNKNOWN","sponsor":"Hangzhou Grand Biologic Pharmaceutical, Inc.","startDate":"2019-06-17","conditions":"Helicobacter Pylori Eradication","enrollment":238},{"nctId":"NCT02479581","phase":"PHASE2","title":"The Safety and Efficacy of the Enhanced Recovery After Surgery(ERAS)Applied on Cardiac Surgery With Cardiopulmonary Bypass","status":"COMPLETED","sponsor":"Xiangya Hospital of Central South University","startDate":"2015-07","conditions":"Valvular Heart Disease","enrollment":226}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"ANAEMIA"},{"count":1,"reaction":"COAGULOPATHY"},{"count":1,"reaction":"DRUG ERUPTION"},{"count":1,"reaction":"HYPOGLOBULINAEMIA"},{"count":1,"reaction":"HYPOKALAEMIA"},{"count":1,"reaction":"HYPOPROTEINAEMIA"},{"count":1,"reaction":"LYMPHOCYTE COUNT DECREASED"},{"count":1,"reaction":"MYOCARDIAL ISCHAEMIA"},{"count":1,"reaction":"NEUTROPHIL COUNT DECREASED"},{"count":1,"reaction":"PAIN"}],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Nexium","Esomeprazole Magnesium"],"phase":"phase_3","status":"active","brandName":"Esomeprazole Magnesium Enteric-coated Tablets","genericName":"Esomeprazole Magnesium Enteric-coated Tablets","companyName":"Fifth Affiliated Hospital, Sun Yat-Sen University","companyId":"fifth-affiliated-hospital-sun-yat-sen-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Esomeprazole magnesium is a proton pump inhibitor that suppresses gastric acid secretion by irreversibly blocking the H+/K+-ATPase enzyme in gastric parietal cells. Used for Gastroesophageal reflux disease (GERD), Peptic ulcer disease, Zollinger-Ellison syndrome.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}