{"id":"esmolol-injection-brevibloc","safety":{"commonSideEffects":[{"rate":"25","effect":"Hypotension"},{"rate":"10","effect":"Dizziness"},{"rate":"7","effect":"Somnolence"},{"rate":"7","effect":"Nausea"},{"rate":"2","effect":"Headache"},{"rate":"8","effect":"Infusion site reactions"}]},"_chembl":{"chemblId":"CHEMBL1201115","moleculeType":"Small molecule","molecularWeight":"331.84"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Esmolol competitively inhibits beta-1 adrenergic receptors on cardiac tissue, decreasing the effects of catecholamines and reducing cardiac contractility and heart rate. It has a very short half-life (approximately 9 minutes) due to rapid metabolism by red blood cell esterases, making it suitable for acute intravenous use in perioperative settings. Its cardioselective beta-1 blockade provides hemodynamic control with minimal effects on beta-2 receptors in the lungs.","oneSentence":"Esmolol is a selective beta-1 adrenergic receptor antagonist that rapidly blocks sympathetic stimulation of the heart, reducing heart rate and blood pressure.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:11:32.055Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Intraoperative and postoperative tachycardia"},{"name":"Intraoperative and postoperative hypertension"},{"name":"Supraventricular tachycardia"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Anatomical Therapeutic Chemical (ATC) code: C07AB09","Esmolol Hydrochloride"],"phase":"phase_3","status":"active","brandName":"Esmolol Injection [Brevibloc]","genericName":"Esmolol Injection [Brevibloc]","companyName":"Consorcio Centro de Investigación Biomédica en Red (CIBER)","companyId":"consorcio-centro-de-investigaci-n-biom-dica-en-red-ciber","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Esmolol is a selective beta-1 adrenergic receptor antagonist that rapidly blocks sympathetic stimulation of the heart, reducing heart rate and blood pressure. Used for Intraoperative and postoperative tachycardia, Intraoperative and postoperative hypertension, Supraventricular tachycardia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}