{"id":"escitalopram-and-tramadol","safety":{"commonSideEffects":[{"rate":"15-25","effect":"Nausea"},{"rate":"10-20","effect":"Dizziness"},{"rate":"10-15","effect":"Headache"},{"rate":"10-20","effect":"Constipation"},{"rate":"rare","effect":"Serotonin syndrome"},{"rate":"rare","effect":"Seizures"},{"rate":"10-15","effect":"Somnolence"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Escitalopram increases serotonin availability in the brain by blocking its reuptake at the synaptic cleft, addressing depressive symptoms. Tramadol acts as a weak mu-opioid receptor agonist and inhibits reuptake of norepinephrine and serotonin, providing analgesic effects. The combination targets both mood and pain pathways, though concurrent use carries risk of serotonin syndrome due to additive serotonergic effects.","oneSentence":"This combination pairs a selective serotonin reuptake inhibitor (escitalopram) with an opioid analgesic and norepinephrine reuptake inhibitor (tramadol) to treat depression and pain conditions.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:32:41.811Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Depression with concurrent pain conditions"},{"name":"Major depressive disorder with chronic pain"}]},"trialDetails":[{"nctId":"NCT05830279","phase":"","title":"Implementation of Personalized Medicine for Optimal Drug Therapy in Cancer","status":"RECRUITING","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2023-05-01","conditions":"Nausea With Vomiting Chemotherapy-Induced, Depression, Reactive, Cancer Pain","enrollment":600},{"nctId":"NCT02297126","phase":"NA","title":"A Prospective Trial to Assess Cost and Clinical Outcomes of a Clinical Pharmacogenomic Program","status":"COMPLETED","sponsor":"Indiana University","startDate":"2015-03","conditions":"Adverse Drug Reaction","enrollment":4465},{"nctId":"NCT00386243","phase":"NA","title":"Evaluation of Stepped Care for Chronic Pain in Iraq/Afghanistan Veterans (ESCAPE)","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2007-12","conditions":"Low Back Pain, Pain, Pain, Intractable","enrollment":242},{"nctId":"NCT02191358","phase":"","title":"YouScript IMPACT Registry","status":"COMPLETED","sponsor":"Genelex Corporation","startDate":"2014-10","conditions":"Adverse Drug Events, Adverse Drug Reactions, Drug Interaction Potentiation","enrollment":800},{"nctId":"NCT00692263","phase":"PHASE4","title":"The Effect of Escitalopram on the Pharmacokinetics and Pharmacodynamics of Tramadol in Healthy Subjects","status":"COMPLETED","sponsor":"University of Southern Denmark","startDate":"2008-02","conditions":"Healthy","enrollment":15}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Lexapro","Ultram"],"phase":"marketed","status":"active","brandName":"escitalopram and tramadol","genericName":"escitalopram and tramadol","companyName":"University of Southern Denmark","companyId":"university-of-southern-denmark","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination pairs a selective serotonin reuptake inhibitor (escitalopram) with an opioid analgesic and norepinephrine reuptake inhibitor (tramadol) to treat depression and pain conditions. Used for Depression with concurrent pain conditions, Major depressive disorder with chronic pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}