{"id":"escin","rwe":[{"pmid":"41901199","year":"2026","title":"Cycloartane-Type Saponins, Phytochemical-Rich Extracts, and Sub-Extracts from Astragalus noeanus Boiss. Exhibit In Vitro and In Silico Effects on Glucose Metabolism.","finding":"","journal":"Pharmaceuticals (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41805617","year":"2025","title":"[The possibility of using local remedies to reduce the frequency of the 'string' symptom after radiofrequency obliteration of the trunk of the large saphenous vein].","finding":"","journal":"Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery","studyType":"Clinical Study"},{"pmid":"41669659","year":"2026","title":"Effect of Escin in Human Hair Follicular Organ Culture: Prolonged Anagen Phase.","finding":"","journal":"Chonnam medical journal","studyType":"Clinical Study"},{"pmid":"41470759","year":"2025","title":"Supplementation with Bromelain, Troxerutin, and Escin to Support Postoperative Recovery After Hip or Knee Arthroplasty in Older Adults: A Pilot Study.","finding":"","journal":"Nutrients","studyType":"Clinical Study"},{"pmid":"41436910","year":"2026","title":"Formulation and characterization of escin loaded-chitosan nanoparticles and assessment of its anti-arthritic potential in Wistar rats: a mechanistic approach.","finding":"","journal":"Inflammopharmacology","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Cardiovascular Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"aescin","offLabel":[],"synonyms":["escin","aescin","aescine","aescusan","escusan"],"timeline":[],"approvals":[],"brandName":"Aescin","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your blood vessels are like a stretchy rubber band. Aescin helps keep the rubber band from stretching too much, which can lead to problems like varicose veins. By keeping the blood vessels stable, Aescin helps blood flow more smoothly and reduces swelling.","oneSentence":"Aescin works by stabilizing blood vessel walls and improving blood flow.","technicalDetail":"Aescin exerts its effects by inhibiting the release of histamine and other mediators from mast cells, leading to reduced vascular permeability and improved blood flow."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Aescin","title":"Aescin","extract":"Aescin or escin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum. Aescin is the main active component in horse chestnut, and is responsible for most of its medicinal properties. The main active compound of aescin is β-aescin, although the mixture also contains various other components including α-aescin, protoescigenin, barringtogenol, cryptoescin and benzopyrones."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2956","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=ESCIN","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ESCIN","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Aescin","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T11:11:17.798743","biosimilars":[],"competitors":[],"genericName":"escin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT05925855","phase":"NA","title":"Effect of Phonophoresis on Trigger Points","status":"COMPLETED","sponsor":"Batterjee Medical College","startDate":"2023-07-01","conditions":["Trigger Point Pain, Myofascial"],"enrollment":20,"completionDate":"2023-12-30"},{"nctId":"NCT07244029","phase":"NA","title":"Aescin-Based Herbal Extract (Reparil) for Postoperative Sequelae After Mandibular Third Molar Surgery","status":"RECRUITING","sponsor":"Oman Medical Speciality Board","startDate":"2026-01-01","conditions":["Postoperative Pain","Facial Swelling","Trismus"],"enrollment":100,"completionDate":"2026-09-30"},{"nctId":"NCT07304882","phase":"PHASE3","title":"A Comparison of Recovery After Impacted Wisdom Tooth Removal","status":"COMPLETED","sponsor":"University of Science and Technology, Yemen","startDate":"2023-11-30","conditions":["Impacted Mandibular Third Molar Extraction","Post Operative Complications"],"enrollment":24,"completionDate":"2025-01-04"},{"nctId":"NCT06748014","phase":"EARLY_PHASE1","title":"The Efficacy of Aescin in Combination With Micronized Purified Flavonoid Fraction (MPFF) in the Control of Bleeding and Prevent Recurrence of Acute Internal Hemorrhoids, A Randomized Controlled Trial, A Pilot Study","status":"ENROLLING_BY_INVITATION","sponsor":"Chiang Mai University","startDate":"2024-12-20","conditions":["Hemorrhoid"],"enrollment":120,"completionDate":"2025-12"},{"nctId":"NCT06363513","phase":"NA","title":"The Efficacy of Aescin in Combination With MPFF in the Early Control of Bleeding From Acute Internal Hemorrhoids, A Randomized Controlled Trial","status":"NOT_YET_RECRUITING","sponsor":"Chiang Mai University","startDate":"2024-04","conditions":["Anorectal Disorder"],"enrollment":60,"completionDate":"2024-05"},{"nctId":"NCT05984641","phase":"NA","title":"Efficacy and Safety of CONAN® Proctological Cream for Treatment of Haemorrhoidal Disease","status":"COMPLETED","sponsor":"Omikron Italia S.r.l.","startDate":"2022-03-01","conditions":["Hemorrhoid Pain","Haemorrhoid Inflammation"],"enrollment":40,"completionDate":"2022-09-30"},{"nctId":"NCT04657874","phase":"NA","title":"Bromelain and Escin in the Reduction of Postoperative Sequelae in Periodontal and Implant Surgery","status":"COMPLETED","sponsor":"University of L'Aquila","startDate":"2020-12-01","conditions":["Postoperative Pain","Edema","Swelling Lips & Face"],"enrollment":20,"completionDate":"2021-05-27"},{"nctId":"NCT04322344","phase":"PHASE2,PHASE3","title":"Escin in Patients With Covid-19 Infection","status":"UNKNOWN","sponsor":"University of Catanzaro","startDate":"2020-03-23","conditions":["Coronavirus Infections"],"enrollment":120,"completionDate":"2020-12-30"},{"nctId":"NCT03104985","phase":"NA","title":"LLLT of Trophic Ulcers of Lower Extremities and Chronic Venous Insufficiency","status":"COMPLETED","sponsor":"Research Center Matrix","startDate":"2013-05","conditions":["Trophic Ulcers","Chronic Venous Insufficiency"],"enrollment":68,"completionDate":"2015-12"},{"nctId":"NCT02346058","phase":"PHASE4","title":"Efficacy and Safety of Esarin Gel in Chronic Venous Insufficiency and Varicose Veins","status":"COMPLETED","sponsor":"Ten Sun Pharma Company Limited","startDate":"2013-10","conditions":["Chronic Venous Insufficiency","Varicose Vein","Superficial Vein Thrombophlebitis"],"enrollment":53,"completionDate":"2014-10"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000168475","NDDF":"005569","UNII":"RUU8G67GQM","CHEBI":"CHEBI:2500","RXNORM":"4065","UMLSCUI":"C0014838","ChEMBL_ID":"CHEMBL4594473","KEGG_DRUG":"D07912","DRUGBANK_ID":"DB15907","PUBCHEM_CID":"6476031","SNOMEDCT_US":"702951009","MESH_DESCRIPTOR_UI":"D004928"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":612,"therapeuticAreas":["Hematology"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Feb 25","pmid":"41901199","title":"Cycloartane-Type Saponins, Phytochemical-Rich Extracts, and Sub-Extracts from Astragalus noeanus Boiss. Exhibit In Vitro and In Silico Effects on Glucose Metabolism.","journal":"Pharmaceuticals (Basel, Switzerland)"},{"date":"2025 Dec 30","pmid":"41805617","title":"[The possibility of using local remedies to reduce the frequency of the 'string' symptom after radiofrequency obliteration of the trunk of the large saphenous vein].","journal":"Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery"},{"date":"2026 Jan","pmid":"41669659","title":"Effect of Escin in Human Hair Follicular Organ Culture: Prolonged Anagen Phase.","journal":"Chonnam medical journal"},{"date":"2025 Dec 5","pmid":"41470759","title":"Supplementation with Bromelain, Troxerutin, and Escin to Support Postoperative Recovery After Hip or Knee Arthroplasty in Older Adults: A Pilot Study.","journal":"Nutrients"},{"date":"2026 Feb","pmid":"41436910","title":"Formulation and characterization of escin loaded-chitosan nanoparticles and assessment of its anti-arthritic potential in Wistar rats: a mechanistic approach.","journal":"Inflammopharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Aescin is a compound that has been studied in clinical trials for various conditions, including trigger point pain, myofascial pain, chronic venous insufficiency, varicose veins, superficial vein thrombophlebitis, and coronavirus infections. The exact mechanism of action of aescin is unknown, but it has been used in combination with ultrasound (phonophoresis) and other treatments in clinical trials.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}