{"id":"esatenolol","rwe":[],"tags":[{"label":"s-atenolol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Adenosine receptor A3","category":"target"},{"label":"ADORA3","category":"gene"},{"label":"ADRB1","category":"gene"},{"label":"ADRB2","category":"gene"},{"label":"C07AB11","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"(-)-atenolol","offLabel":[],"synonyms":["s-atenolol","(-)-Atenolol","(S)-Atenolol","esatenolol"],"timeline":[],"aiSummary":"-)-Atenolol (ESATENOLOL) is a small molecule drug that targets the adenosine receptor A3. It belongs to the s-atenolol class and its mechanism of action is not well-documented. There is limited information available on its commercial status, approved indications, and pharmacokinetic properties. Further research is needed to fully understand the properties and potential uses of this compound. As a result, it is not clear if it is patented or available as a generic medication.","approvals":[],"brandName":"(-)-Atenolol","ecosystem":[],"mechanism":{"target":"Adenosine receptor A3, Beta-1 adrenergic receptor, Beta-2 adrenergic receptor","targets":[{"gene":"ADORA3","source":"DrugCentral","target":"Adenosine receptor A3","protein":"Adenosine receptor A3"},{"gene":"ADRB1","source":"DrugCentral","target":"Beta-1 adrenergic receptor","protein":"Beta-1 adrenergic receptor"},{"gene":"ADRB2","source":"DrugCentral","target":"Beta-2 adrenergic receptor","protein":"Beta-2 adrenergic receptor"}],"modality":"Small Molecule","drugClass":"s-atenolol","explanation":"Think of adenosine like a messenger in your body that helps regulate different functions. When ESATENOLOL binds to the adenosine receptor A3, it can influence how this messenger works, potentially leading to changes in heart rate, blood pressure, or other bodily responses.","oneSentence":"ESATENOLOL works by binding to the adenosine receptor A3, which can affect various physiological processes.","technicalDetail":"ESATENOLOL's mechanism of action involves the selective binding to the A3 subtype of adenosine receptors, which may modulate downstream signaling pathways and influence cardiovascular and other physiological processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4702","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ESATENOLOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:11:12.107786","biosimilars":[],"competitors":[{"drugName":"metoprolol","drugSlug":"metoprolol","fdaApproval":"1978-08-07","patentExpiry":"Jul 9, 2035","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"atenolol","drugSlug":"atenolol","fdaApproval":"1981-08-19","genericCount":22,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"acebutolol","drugSlug":"acebutolol","fdaApproval":"1984-12-28","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"betaxolol","drugSlug":"betaxolol","fdaApproval":"1985-08-30","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"bisoprolol","drugSlug":"bisoprolol","fdaApproval":"1992-07-31","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"esmolol","drugSlug":"esmolol","fdaApproval":"1986-12-31","patentExpiry":"Mar 15, 2033","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"nebivolol","drugSlug":"nebivolol","fdaApproval":"2007-12-17","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"esatenolol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"metoprolol","brandName":"metoprolol","genericName":"metoprolol","approvalYear":"1978","relationship":"same-class"},{"drugId":"atenolol","brandName":"atenolol","genericName":"atenolol","approvalYear":"1981","relationship":"same-class"},{"drugId":"acebutolol","brandName":"acebutolol","genericName":"acebutolol","approvalYear":"1984","relationship":"same-class"},{"drugId":"betaxolol","brandName":"betaxolol","genericName":"betaxolol","approvalYear":"1985","relationship":"same-class"},{"drugId":"bisoprolol","brandName":"bisoprolol","genericName":"bisoprolol","approvalYear":"1992","relationship":"same-class"},{"drugId":"esmolol","brandName":"esmolol","genericName":"esmolol","approvalYear":"1986","relationship":"same-class"},{"drugId":"nebivolol","brandName":"nebivolol","genericName":"nebivolol","approvalYear":"2007","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"DPF757BOSR","CHEBI":"CHEBI:31556","INN_ID":"7337","UMLSCUI":"C3652674","ChEMBL_ID":"CHEMBL343633","KEGG_DRUG":"D01471","DRUGBANK_ID":"DB13443","PUBCHEM_CID":"175540"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"C07AB11","allCodes":["C07AB11"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}