{"id":"erythropoietin-subcutaneously-and-iron-intravenously","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Hypertension"},{"rate":"1-5","effect":"Thrombosis"},{"rate":"5-15","effect":"Headache"},{"rate":"5-10","effect":"Injection site reactions"},{"rate":"10-20","effect":"Gastrointestinal disturbance (iron-related)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Erythropoietin (EPO) is a cytokine that binds to erythropoietin receptors on bone marrow progenitor cells, promoting their differentiation and proliferation into mature red blood cells. Iron supplementation ensures adequate iron availability for hemoglobin synthesis, as iron is a critical component of the heme molecule. Together, these agents address both the signaling deficiency and nutritional substrate needed for effective erythropoiesis.","oneSentence":"Erythropoietin stimulates red blood cell production while intravenous iron provides the essential substrate for hemoglobin synthesis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:45:44.739Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anemia of chronic kidney disease"},{"name":"Chemotherapy-induced anemia"},{"name":"Iron deficiency anemia"}]},"trialDetails":[{"nctId":"NCT02879305","phase":"PHASE3","title":"Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Dialysis (ASCEND-D)","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2016-09-28","conditions":"Anaemia, Aspergillosis, Allergic Bronchopulmonary","enrollment":2964},{"nctId":"NCT03029208","phase":"PHASE3","title":"Anemia Studies in Chronic Kidney Disease (CKD): Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat-in Incident Dialysis (ASCEND-ID)","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2017-05-11","conditions":"Anaemia","enrollment":312},{"nctId":"NCT02210949","phase":"PHASE4","title":"Pre-operative Treatment With Erythropoietin and Iron Supplement in Cardiac Surgery","status":"TERMINATED","sponsor":"Catharina Ziekenhuis Eindhoven","startDate":"2014-08","conditions":"Heart; Dysfunction Postoperative, Cardiac Surgery, Anemia, Iron-Deficiency","enrollment":7},{"nctId":"NCT01012063","phase":"NA","title":"Perioperative Iron With Erythropoietin in Bilateral Total Knee Replacement Arthroplasty (TKRA)","status":"COMPLETED","sponsor":"Seoul National University Bundang Hospital","startDate":"2008-08","conditions":"Anemia, Transfusion","enrollment":54},{"nctId":"NCT00557817","phase":"PHASE2, PHASE3","title":"Erythropoietin (Epo) and Venofer Trial After Autologous Hematopoietic Stem Cell Transplantation (HSCT)","status":"COMPLETED","sponsor":"University of Liege","startDate":"2004-03","conditions":"Hematological Malignancies","enrollment":125}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":57,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Eprex","Ferinject"],"phase":"marketed","status":"active","brandName":"Erythropoietin subcutaneously and Iron intravenously","genericName":"Erythropoietin subcutaneously and Iron intravenously","companyName":"Catharina Ziekenhuis Eindhoven","companyId":"catharina-ziekenhuis-eindhoven","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Erythropoietin stimulates red blood cell production while intravenous iron provides the essential substrate for hemoglobin synthesis. Used for Anemia of chronic kidney disease, Chemotherapy-induced anemia, Iron deficiency anemia.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}