{"id":"erythromycin-acistrate","rwe":[{"pmid":"11072193","year":"2000","title":"Effect of compression force on the crystal properties of erythromycin acistrate tablets.","finding":"","journal":"European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V","studyType":"Clinical Study"},{"pmid":"9885307","year":"1998","title":"The effect of compression force on surface structure, crushing strength, friability and disintegration time of erythromycin acistrate tablets.","finding":"","journal":"European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V","studyType":"Clinical Study"},{"pmid":"9795044","year":"1998","title":"Dependence between dissolution rate and porosity of compressed erythromycin acistrate tablets.","finding":"","journal":"European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V","studyType":"Clinical Study"},{"pmid":"8726299","year":"1996","title":"The Helicobacter felis mouse model in assessing anti-Helicobacter therapies and gastric mucosal prostaglandin E2 levels.","finding":"","journal":"Scandinavian journal of gastroenterology","studyType":"Clinical Study"},{"pmid":"8222874","year":"1993","title":"Efficacy and tolerance of erythromycin acistrate in the treatment of acute exacerbations of chronic bronchitis in the elderly.","finding":"","journal":"Chemotherapy","studyType":"Clinical Study"}],"tags":[{"label":"Macrolide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Gastrointestinal Agents","category":"pharmacology"},{"label":"Protein Synthesis Inhibitors","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"erasis","offLabel":[],"synonyms":["erythromycin acistrate","oxacyclotetradecane, erythromycin deriv.","2'-Acetylerythromycin stearate","erasis"],"timeline":[],"approvals":[],"brandName":"Erasis","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"Macrolide","explanation":"Imagine your body's cells are like factories that make proteins to keep you healthy. Bacteria are like tiny factories that make proteins to harm you. Erythromycin Acistrate stops these bacterial factories from working by binding to a crucial part of the machinery, effectively shutting them down.","oneSentence":"Erythromycin Acistrate works by binding to the bacterial ribosome and preventing the production of essential proteins.","technicalDetail":"Erythromycin Acistrate binds to the 50S subunit of the bacterial ribosome, specifically to the 23S rRNA, thereby inhibiting the translocation step of protein synthesis and preventing the production of essential proteins."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1049","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ERYTHROMYCIN ACISTRATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:01:54.653697","biosimilars":[],"competitors":[],"genericName":"erythromycin acistrate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"MMSL":"4675","NDDF":"002755","UNII":"6383U5A1KE","CHEBI":"CHEBI:135882","VANDF":"4017594","INN_ID":"5728","RXNORM":"4053","UMLSCUI":"C0116531","ChEMBL_ID":"CHEMBL2110577","KEGG_DRUG":"D02523","DRUGBANK_ID":"DB00199","PUBCHEM_CID":"5284554","SNOMEDCT_US":"30427009","MESH_DESCRIPTOR_UI":"D004917","MESH_SUPPLEMENTAL_RECORD_UI":"C056625"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":29,"therapeuticAreas":["Infectious Disease"],"biosimilarFilings":[],"recentPublications":[{"date":"2000 Nov","pmid":"11072193","title":"Effect of compression force on the crystal properties of erythromycin acistrate tablets.","journal":"European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V"},{"date":"1998 Nov","pmid":"9885307","title":"The effect of compression force on surface structure, crushing strength, friability and disintegration time of erythromycin acistrate tablets.","journal":"European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V"},{"date":"1998 Sep","pmid":"9795044","title":"Dependence between dissolution rate and porosity of compressed erythromycin acistrate tablets.","journal":"European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V"},{"date":"1996 Apr","pmid":"8726299","title":"The Helicobacter felis mouse model in assessing anti-Helicobacter therapies and gastric mucosal prostaglandin E2 levels.","journal":"Scandinavian journal of gastroenterology"},{"date":"1993 Nov-Dec","pmid":"8222874","title":"Efficacy and tolerance of erythromycin acistrate in the treatment of acute exacerbations of chronic bronchitis in the elderly.","journal":"Chemotherapy"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Erasis is a small molecule. It is also known by other names, including erythromycin acistrate, acistrate d'erythromycine, acistrato de eritromicina, and erythromycin acistrate.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}