{"id":"er-zhi-wan-combined-with-si-wu-tang","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Allergic reaction to herbal components"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Er Zhi Wan (Two Immortals Decoction) traditionally tonifies liver and kidney yin, while Si Wu Tang (Four Substances Decoction) nourishes blood and invigorates circulation. The combination is used in Chinese medicine to address yin deficiency with blood stasis, commonly applied to age-related vision decline and hematologic disorders. The mechanism is based on traditional Chinese medicine theory rather than identified molecular targets.","oneSentence":"This traditional Chinese medicine combination nourishes blood and yin to address deficiency-related conditions, particularly those affecting vision and hematologic function.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:11:26.111Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Age-related macular degeneration or vision decline"},{"name":"Anemia or hematologic deficiency conditions"}]},"trialDetails":[{"nctId":"NCT04935073","phase":"PHASE3","title":"Traditional Chinese Medicine Herbs in the Freeze-all IVF Cycle","status":"UNKNOWN","sponsor":"Peking University Third Hospital","startDate":"2021-06-15","conditions":"Infertility, Female","enrollment":90},{"nctId":"NCT04842825","phase":"PHASE3","title":"Sequential Therapy of TCM Herbs to Improve the Success Rate of IVF-ET in Diminished Ovarian Reserve Patients","status":"UNKNOWN","sponsor":"Peking University Third Hospital","startDate":"2021-04-15","conditions":"Infertility, Female","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["conventional western medicine(Recombinant Human Follitropin Alfa for Injection、Fructose Injection、Tetyacycline Hydrochloride Capsules、Cetrorelix Acetate Powder for Injection )"],"phase":"phase_3","status":"active","brandName":"Er Zhi Wan combined with Si Wu Tang","genericName":"Er Zhi Wan combined with Si Wu Tang","companyName":"Peking University Third Hospital","companyId":"peking-university-third-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This traditional Chinese medicine combination nourishes blood and yin to address deficiency-related conditions, particularly those affecting vision and hematologic function. Used for Age-related macular degeneration or vision decline, Anemia or hematologic deficiency conditions.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}