{"id":"eptazocine","rwe":[{"pmid":"30254698","year":"2018","title":"A novel and practical asymmetric synthesis of eptazocine hydrobromide.","finding":"","journal":"Beilstein journal of organic chemistry","studyType":"Clinical Study"},{"pmid":"22907930","year":"2012","title":"Asymmetric syntheses of (-)-pentazocine and (-)-eptazocine through an aza-Prins cyclization.","finding":"","journal":"Chemistry, an Asian journal","studyType":"Clinical Study"},{"pmid":"12392093","year":"2002","title":"Investigation on the influx transport mechanism of pentazocine at the blood-brain barrier in rats using the carotid injection technique.","finding":"","journal":"Biological & pharmaceutical bulletin","studyType":"Clinical Study"},{"pmid":"12379919","year":"2002","title":"Investigation of transport mechanism of pentazocine across the blood-brain barrier using the in situ rat brain perfusion technique.","finding":"","journal":"Journal of pharmaceutical sciences","studyType":"Clinical Study"},{"pmid":"11145186","year":"2000","title":"Pharmacokinetic/pharmacodynamic relationship of eptazocine, a narcotic-antagonist analgesic, in rats.","finding":"","journal":"Biological & pharmaceutical bulletin","studyType":"Clinical Study"}],"tags":[{"label":"eptazocine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"sedapain","offLabel":[],"synonyms":["eptazocine","sedapain","(-)-Eptazocine"],"timeline":[],"approvals":[],"brandName":"Sedapain","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"eptazocine","explanation":"Imagine your brain has many locks, and each lock has a specific key that fits perfectly. Eptazocine is like a key that fits into a specific lock, called the kappa opioid receptor, which helps to reduce pain signals sent to the brain.","oneSentence":"Eptazocine is a kappa opioid receptor agonist, which means it binds to and activates a specific type of opioid receptor in the brain.","technicalDetail":"Eptazocine acts as a kappa opioid receptor agonist, activating the G-protein coupled receptor 54 (KOR) to modulate pain perception and other physiological responses."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1039","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=EPTAZOCINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:04:32.894094","biosimilars":[],"competitors":[],"genericName":"eptazocine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"2208ZLI77S","CHEBI":"CHEBI:134944","INN_ID":"5043","UMLSCUI":"C0059489","ChEMBL_ID":"CHEMBL70566","KEGG_DRUG":"D07904","PUBCHEM_CID":"3042090","MESH_SUPPLEMENTAL_RECORD_UI":"C033776"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":25,"therapeuticAreas":["Pain"],"biosimilarFilings":[],"recentPublications":[{"date":"2018","pmid":"30254698","title":"A novel and practical asymmetric synthesis of eptazocine hydrobromide.","journal":"Beilstein journal of organic chemistry"},{"date":"2012 Nov","pmid":"22907930","title":"Asymmetric syntheses of (-)-pentazocine and (-)-eptazocine through an aza-Prins cyclization.","journal":"Chemistry, an Asian journal"},{"date":"2002 Oct","pmid":"12392093","title":"Investigation on the influx transport mechanism of pentazocine at the blood-brain barrier in rats using the carotid injection technique.","journal":"Biological & pharmaceutical bulletin"},{"date":"2002 Nov","pmid":"12379919","title":"Investigation of transport mechanism of pentazocine across the blood-brain barrier using the in situ rat brain perfusion technique.","journal":"Journal of pharmaceutical sciences"},{"date":"2000 Dec","pmid":"11145186","title":"Pharmacokinetic/pharmacodynamic relationship of eptazocine, a narcotic-antagonist analgesic, in rats.","journal":"Biological & pharmaceutical bulletin"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sedapain (Eptazocine) is a small molecule drug in the eptazocine class, but its target and exact mechanism of action are unknown. It is not clear if it has been approved by the FDA or if it is commercially available. As more information is not available, it is difficult to provide a comprehensive summary. Further research is needed to understand its approved indications, pharmacokinetic properties, and safety considerations. Its commercial status, including patent status and generic availability, is also unclear.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}